Publications from 2021 to 2026
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Design, synthesis, and in vitro/in vivo biological evaluation of Artesunate-Ebselen derivatives: GPX4-targeted ferroptosis induction and synergistic antitumor immune activation in colorectal cancer.
Silk fibroin microneedles with controlled release kinetics for extended protection against soman intoxication
Macrophage METTL3 synergizes with YTHDF2 to promote atherosclerosis by inhibiting the LXR-α/ABCA1 pathway.
METTL16 improves cigarette smoking-induced COPD emphysema through inhibiting autophagy by mediating pri-miR-511 m6A modification.
Versatile polymeric membrane ion-selective electrodes based on cellulose triacetate.
Nowadays, polymeric membrane ion-selective electrodes (ISEs) based on poly(vinyl chloride) (PVC) matrices are widely used in clinical diagnosis and environmental monitoring. However, the chemical inertness of PVC may limit sensor applications in some scenarios, such as surface modification and construction of potentiometric biosensors through surface grafting of receptors. In this work, cellulose triacetate (CTA) is employed as a membrane matrix to prepare polymeric membrane ISEs. The versatile properties of the proposed CTA-based potentiometric sensors in terms of biocompatibility, biodegradability and easy chemical modification are illustrated. As a proof-of-concept experiment, polymeric membrane Ca2+-ISEs using CTA as the membrane matrix have been fabricated. The electrode has a linear range of 1.0 × 10-5 to 1.0 × 10-2 M with a Nernstian slope of 29.19 ± 0.97 mV dec-1. A surface hydrophilic CTA-based Ca2+-ISE membrane can be simply obtained by alkaline hydrolysis of the electrode. The hydrolyzed surface of the obtained membrane can further be activated with carbonyldiimidazole (CDI) for the direct immobilization of the functionalized agent, polysaccharide chitosan, on the surface of the membranes. In addition, an enzyme, butyrylcholinesterase, can also be immobilized onto the ISE surface through a similar CDI reaction, which provides great potential for fabrication of new potentiometric biosensors. It will be shown that CTA can be used as a powerful membrane matrix alternative to the classical PVC matrix for fabrication of polymeric membrane optical and electrochemical sensors in clinical applications.
Read moreCHAtRF Modulates Cardiac Hypertrophy via SRSF5-Dependent Regulation of Psmg4 Alternative Splicing
tRNA-derived small RNAs (tsRNAs) or tRNA-derived fragments (tRFs) are an important class of regulatory molecules whose role in cardiac hypertrophy remains largely unknown. Here, we identified a novel tRF contributing to the regulation of cardiac hypertrophy that we termed CHAtRF (cardiac hypertrophy-associated tRF). The CHAtRF level was increased in mice and in patients with cardiac hypertrophy. CHAtRF deficiency attenuated angiotensin II (AngII)-induced cardiac hypertrophy and restored the heart function, while CHAtRF overexpression enhanced hypertrophic responses. Mechanistically, CHAtRF directly interacts with SRSF5 and blocks SRSF5 to bind with Psmg4 pre-mRNA, which mediates alternative splicing of Psmg4 pre-mRNA and promotes exon 2 skipping of Psmg4. CHAtRF-dependent alternative splicing of Psmg4 inhibits the expression of Psmg4 full-length isoform, resulting in progression of pathological hypertrophy. The ability of CHAtRF to regulate hypertrophy was confirmed in hiPSC-CMs, and CHAtRF serum levels are higher in individuals with myocardial hypertrophy or heart failure. Our findings reveal new insights into the previously unrecognized role of tsRNAs during cardiac hypertrophy, which provide potential novel therapeutic targets for pathological hypertrophy and might serve as potential biomarkers for diagnosing cardiac hypertrophy and heart failure.
Read moreComparative evaluation of [¹⁸F]FAPI-42 and [¹⁸F]PSMA-1007 PET/CT for lesion detection and uptake in prostate cancer across disease stages.
Although [¹⁸F]PSMA-1007 enables sensitive detection in prostate cancer, heterogeneity in PSMA expression and variable physiologic uptake can limit performance, whereas [¹⁸F]FAPI-42, targeting fibroblast activation protein in tumor stroma and typically exhibiting low background, may improve conspicuity in regions affected by physiologic PSMA activity and in phenotypes with reduced PSMA expression. This study aimed to compare [¹⁸F]FAPI-42 and [¹⁸F]PSMA-1007 PET/CT in patients with prostate cancer, and assess lesion detection rates and uptake on [¹⁸F]FAPI-42 PET/CT across various disease stages. Of 759 lesions from 55 patients, 187 were PSMA-positive only, 72 were FAPI-positive only, and 500 were positive on both tracers. [¹⁸F]PSMA-1007 detected more lesions in newly diagnosed (233 vs. 181, P = 0.0001), biochemical recurrence (BCR) (67 vs. 56, P = 0.04), and castration-resistant prostate cancer(CRPC) (385 vs. 333, P < 0.0001) groups. [¹⁸F]PSMA-1007 also demonstrated higher SUVmax and TBRblood than [¹⁸F]FAPI-42 PET/CT for primary/recurrent tumors (SUVmax 15.5 ± 16.8 vs. 4.2 ± 2.2; TBRblood 13.5 ± 14.0 vs. 3.5 ± 2.9), lymph node (SUVmax 14.9 ± 15.3 vs. 3.8 ± 2.7; TBRblood 12.8 ± 12.1 vs. 3.5 ± 2.9), bone (SUVmax 11.9 ± 9.4 vs. 6.8 ± 3.5; TBRblood 13.1 ± 12.1 vs. 6.3 ± 3.5), and visceral metastases (SUVmax 14.6 ± 9.4 vs. 7.8 ± 4.6; TBRblood 22.8 ± 12.3 vs. 6.9 ± 6.2). Among disease stages, lesion detection rates on [¹⁸F]FAPI-42 were higher in CRPC (84.5%) and BCR (75.7%) than in newly diagnosed cases (62.6%; P < 0.0001 and P = 0.04, respectively). SUVmax of lesion on [¹⁸F]FAPI-42 PET/CT were highest in CRPC (6.6 ± 3.9), followed by BCR (5.9 ± 3.7), and newly diagnosed disease (4.3 ± 2.5; P < 0.005). In 3 of 5 patients with discordant findings favoring [¹⁸F]FAPI-42, clinical management was altered. While [¹⁸F]PSMA 1007 PET/CT remains superior for overall lesion detection, [¹⁸F]FAPI 42 PET/CT may provide complementary value in selected scenarios, particularly in subsets with reduced PSMA expression. Chinese Clinical Trial Registry, ChiCTR2200063441. Registered 06 September 2022, https//www.chictr.org.cn/bin/project/edit? pid=149,714.
Read morePredictive Value of the C-Reactive ProteinTriglycerideGlucose Composite Index for All-Cause Mortality in General Population: A Dual-Cohort Study Based on NHANES and CHARLS
Background: Metabolic dysregulation and chronic inflammation coexist commonly, synergistically increasing cardiovascular and all-cause mortality. Single biomarkers fail to comprehensively assess metabolism-inflammation imbalance.&nbsp;This study first validates the dose-response relationship between CTI (a novel dual-pathway composite biomarker) and all-cause mortality across two cross-continental cohorts.&nbsp;Methods: Data from NHANES (n&nbsp;=&nbsp;7, 752) and CHARLS (n&nbsp;=&nbsp;9, 352) were integrated. CTI was calculated for all participants.&nbsp;Statistical methods including multivariable Cox model, propensity score overlap weighting, RCS regression, and competing risk model analyzed CTI-mortality correlation.&nbsp;Sensitivity analysis and external validation ensured result robustness.&nbsp;Results: Median follow-ups: 11.3 years (NHANES, 1, 260 deaths) and 9 years (CHARLS, 236 deaths).&nbsp;Fully adjusted Model 3: Each 1-unit CTI increase linked to 21% (NHANES: HR&nbsp;=&nbsp;1.21, 95%&nbsp;CI: 1.12&ndash;1.31) and 56% (CHARLS: HR&nbsp;=&nbsp;1.56, 95%&nbsp;CI: 1.34&ndash;1.82) higher all-cause mortality.&nbsp;All-cause mortality surged when CTI&nbsp;>&nbsp;9.77 (NHANES) or >&nbsp;7.54 (CHARLS) (P&nbsp;< 0.001).&nbsp;Highest CTI quartile had 37% (NHANES) and 221% (CHARLS) higher mortality vs. lowest; effect pronounced in middle-aged and elderly (CHARLS, median age 58).&nbsp;CTI (AUC&nbsp;=&nbsp;0.61) outperformed TyG or CRP alone.&nbsp;Conclusions: CTI, integrating inflammatory and metabolic indicators, effectively identifies high-risk individuals across populations.&nbsp;With population-specific thresholds, it is promising for routine health screening risk stratification, guiding early intervention.
Read moreOrchestrating Ovarian Dysfunction- The Role of Programmed Cell Death in PCOS.
Plasma Multi-Metal Exposure, Renal Function, and Anemia Risk in Rural China: The Mediating Role of Serum Creatinine.
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