Gunma Prefectural Women's University

Central nervous system (CNS) prophylaxis is recommended for patients with diffuse large B-cell lymphoma (DLBCL) who are at high risk of CNS relapse. This study aimed to determine the impact of CNS prophylaxis on CNS relapse rates and overall survival (OS) in this patient population, as well as the optimal method for CNS prophylaxis. This was a retrospective analysis of 178 patients with DLBCL at high risk of CNS relapse who were treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) or its derivatives with (N = 60) or without (N = 118) CNS prophylaxis. The 2-year CNS relapse rate was 17.6% in the all-prophylaxis group (HD-MTX 17.4%, IT 48.1%, and HD-MTX + IT 6.2%) and 13.0% in the non-prophylaxis group, with no significant difference between groups. However, HD-MTX + IT decreased the risk of CNS relapse. After a median follow-up of 72.8months, HD-MTX + IT addition significantly improved the 5-year OS (HD-MTX 73.5%, IT 44.4%, HD-MTX + IT 93.2%; non-prophylaxis group 58.0%; p = 0.013). This advantage was maintained in the multivariate analysis (hazard ratio: 0.160; 95% confidence interval: 0.039-0.663; p = 0.012). CNS prophylaxis with HD-MTX + IT improved the prognosis of patients with DLBCL at high risk of CNS relapse.

Lewis (Noûs 13:455–476, 1979) claimed that branching-time(-like) models can be derived from his sphere models. However, he did not present any specific construction of branching-time(-like) models from his sphere models formally. Meanwhile, Hosokawa (in: Modern logic of modality and its philosophical range: counterfactuals, Gettier problem, and information flow, Tokyo Metropolitan University, 2018) presented a logico-mathematically strict manner in which sphere models can be reconstructed from branching-time models. Subsequently, Hosokawa (J Logic Lang Inf 32:677–706, 2023) presented a proof-theoretically refined version of hybrid tense logic for a certain type of conditionals, which is referred to as hybrid tense logic for temporal conditionals (HTLTC). In this paper, we interpret a hybrid version VHC(@,↓) of Lewis’s counterfactual logic V into HTLTC, and then prove that HTLTC is more expressive than VHC(@,↓) on the class of temporal sphere models, i.e., sphere models derived from a type of branching-time models.

Few studies have examined global foreign accent (GFA) in bilingual children, and little is known about how GFA changes over time and what factors determine change. Here, we examine GFA trajectories in Japanese–English bilingual returnees (Japanese children who returned to Japan after having lived in a majority English environment for several years). In two accent-rating tasks, first language (L1) speakers of English or Japanese rated returnee speech excerpts recorded at three time points over a five-year period. The ratings show a decrease in Japanese GFA one year after return to Japan, and an increase in English GFA, but only five years after return. These findings suggest rapid re-exposure effects of the L1 and relatively stable maintenance of the second language (L2). Changes varied by L2 English age of onset (AoO) and exposure to L2 English while abroad, suggesting a crucial role for these individual factors in transitory contexts such as returnee bilingualism.

This study investigated to what extent the scores of two English tests are correlated to each other, namely, the English test of the Common Test for University Admissions (Common Test, henceforth) in Japan and the TOEIC Bridge, a commercially available English test developed by Educational Testing Service (ETS) that measures four skills of listening, reading, speaking, and writing. Moreover, this study examined to what extent the two tests’ constructs overlap from the viewpoint of L2 competence. In total, 128 university freshmen and high school seniors took the Common Test at the official venues and also the TOEIC Bridge at the researcher’s university (n = 92) or at home (n = 36) a few months later. Results indicated that the scores of the corresponding skills are moderately correlated to each other across the two tests (Reading = .548; Listening = .646; Total = .732). Confirmatory factor analyses demonstrated that the degree of data fitting of the three models of test constructs (unitary, correlated skills, correlated tests) was statistically similar to each other. On the basis of substantive and statistical results, however, we claim that the correlated skills model should be chosen as the best-fit model and, consequently, that the productive skills should be measured in addition to the Common Test.

Abstract The present study examines the acquisition of definite noun phrases (NPs) in L2 English. Both English and Spanish have a definite article, but Japanese lacks articles, though definite anaphoric and definite non-anaphoric are present to some degree through the optional use of sono (the/that). A self-paced reading task was administered to assess real-time processing in the comprehension of different types of definite NPs by L2-English learners. The self-paced reading results show processing of definite NPs is influenced by proficiency level rather than L1 transfer effects. We discuss our findings in reference to the Morphological Congruency Hypothesis and the Lexical Learning/Lexical Transfer model and suggest that our data support the latter but not the former.

This paper discusses the concepts of aesthetic and nonaesthetic in streetscapes. The nonaesthetic refers to physical elements and spatial compositions that make the aesthetic emerge differently depending on the observer who sees them. Using Ashihara’s (1979) methodology for evaluating aesthetic townscapes and Sibley’s (1959) concept of aesthetic properties, this paper proposes a quantification of the nonaesthetic of streetscapes, focusing on streets in Ginza, Tokyo, and examining the spatial clustering of their nonaesthetic. For this, we used deep learning to quantify the distribution of physical elements and their spatial composition and a spatial clustering analysis to uncover hidden patterns in the streetscapes. These methodologies enabled us to assess streets across neighborhoods and districts and produce a comparative microscale analysis that covers a wider area. Thus, our study combines the fields of aesthetics, architecture, urban planning, and community design.