Guru Ravidas Ayurved University

Background Antenatal education helps in enhancing a woman's belief in herself, her ability to cope with birth, and achieving the desired outcome from coping behaviour, which will lead to a positive birth experience. Health professionals should impart antenatal education to enhance a mother's belief about her behaviour during childbirth. We aimed to develop and assess the effect of a supportive educational intervention on child birth self-efficacy amongst primipara mothers with a fear of childbirth. Methods We included in our study, 200 primipara mothers at 24-28 weeks of pregnancy with a fear of childbirth. They were screened for fear of childbirth using the Wijma Delivery Expectany Questionnaire-A (WDEQ-A) scale and then randomly allocated to the experimental and control groups. After the childbirth allocation assessment, self-efficacy was assessed using the childbirth self-efficacy inventory. The control group received routine care, and the experimental group received two sessions of intervention, one between 24 and 28 weeks and the second between 32 and 36 weeks of pregnancy. At 37 and 38 weeks of pregnancy, selected mothers in both groups were again assessed for childbirth self-efficacy. Results Following the interventions, there was a significant difference between the groups on post-intervention scores for childbirth self-efficacy (p<0.001). Conclusions Educational interventions can improve self-efficacy of expectant primipara mothers.

The recent Act on Online Gaming passed by both houses of the Parliament has banned real-money online games in India, which will include rummy, fantasy sports, and poker, irrespective of these games being games of skill. The justifications presented behind the law were public morality, the addictive nature of the games, and financial protection of the citizens of India. Though justification has been presented, the ban reflects hard paternalism, where the individual’s choice has been undermined and substituted by the judgment of the state. This article analyses the recently passed Act banning all real-money online games, criticizing the paternalistic stance by the state drawing an analogy with the attack on the decisional autonomy of women in reproductive matters. Though the comparison seems unconventional, in both contexts the intervention of the state strikes the individual autonomy of private decision-making. It raises significant questions about the liberty of the individuals. The reference to decisional autonomy of women in reproductive matters serves as a jurisprudential parallel in determining to what extent can the state in the name of protecting the interests of the people, regulate personal choices. The article suggests a more balanced model of governance that respects individual autonomy.

Introduction: Colorectal cancer (CRC) ranks among the most prevalent malignancies globally, driven by a complex interplay of genetic, molecular, and environmental factors. Dostarlimab, a humanized monoclonal antibody targeting the programmed cell death protein-1 (PD- 1) receptor, has emerged as a breakthrough immunotherapy for CRC, particularly in mismatch repairdeficient (dMMR) subtypes. Its ability to enhance anti-tumor immune responses has positioned it as a promising therapeutic agent, with ongoing research exploring its efficacy across CRC subtypes and in combination therapies. Methods: This study investigates the therapeutic potential of Dostarlimab in CRC management by analyzing scientific data collected from various literature databases, including Google Scholar, Scopus, and PubMed. The review encompasses the genetic and molecular underpinnings of CRC, such as mutations in APC, KRAS, and TP53, and the regulatory roles of non-coding RNAs (ncRNAs). Detailed pharmacological mechanisms, clinical trial outcomes, and comparative efficacy of Dostarlimab against other immunotherapies were evaluated to assess its biological and clinical significance. Analytical aspects of Dostarlimab's pharmacokinetics and pharmacodynamics were also explored. Results: Scientific data analysis underscores the pivotal role of Dostarlimab in CRC treatment, particularly for dMMR/MSI-H subtypes, where it achieved a 100% clinical complete response rate in a phase II trial for locally advanced rectal cancer. The drug's mechanism involves PD-1 inhibition, enhancing T-cell-mediated tumor destruction. Genomic aberrations (e.g., KRAS, BRAF, TP53 mutations) and ncRNAs (e.g., miRNAs and lncRNAs) were identified as key influencers of CRC prognosis and potential therapeutic targets. Dostarlimab exhibits significant efficacy in dMMR/MSI-H CRC, with ongoing trials assessing its impact on mismatch repair-proficient (pMMR) subtypes. Its favorable pharmacokinetic profile (e.g., half-life of 25.4 days) and tolerable safety profile further enhance its clinical utility. Comparative studies with pembrolizumab and nivolumab highlight Dostarlimab's superior response rates in specific CRC cohorts. Conclusion: The scientific data from this review affirm the transformative potential of Dostarlimab in CRC management, offering hope for improved outcomes through personalized immunotherapy. Its integration with genetic and molecular insights paves the way for targeted CRC therapies.

Anaemia is a global health burden with a prevalence of 1.62 billion people, which corresponds to about 24.8% of the total world population. According to National Family Health Survey, Indian children suffer from weight loss, stunted growth and wasting, which is higher than any other country in the world, and 7 out of every 10 young children are anaemic. Homoeopathic management of anaemia along with dietary modifications have been discussed in this review. Objective: To review the literature of published studies relating to homeopathic management of anaemia. Result: Four research studies have been identified related to homoeopathy and anaemia. All of them are clinical trials. Conclusion: Homeopathic Medications are effective in the treatment of anaemia along with dietary modifications.

Metais so largamente empregados em implantes (endoprteses), principalmente nos que tem finalidade ortopdica. O meio fisiolgico representa um meio extremamente agressivo, provocando corroso que ..pode resultar em srios problemas aos pacientes que recebem os implantes. Passou-se a utilizar revestimentos sobre o metal-base de implantes para melhorar a sua resistncia corroso. Mais recentemente, revestimentos porosos de cermica, que permitem ao tecido sseo um crescimento por entre a porosidade, passaram a ser empregados, pois assim dispensam o uso de cimentos acrlicos na fixao da prtese ao osso. A hidroxiapatita (lIA) um dos revestimentos cermicos cuja aplicao comercial tem crescido bastante, principalmente em cirurgias de substituio total de quadril (total hip replacement). A corroso eletroqumica em metais comumente empregados em endoprteses e que aceitam o revestimento de hidroxiapatita (aos inox F138 grau 2, 316L grau 1 e liga Co-Cr-Mo F75) foi estudada, de forma a determinar se este tipo de revestimento influi ou no na .'corro so. Atravs de testes, e anlises metalogrficas e de microscopia eletrnica de varredura, foi analisada a corroso destes materiais em dois meios fisiolgicos (Soro Bovino e Soro Fisiolgico), comparando-se os resultados obtidos com e sem revestimento de hidroxiapatita.