H.T. Harvey & Associates

Constructed floating wetlands (CFWs) provide a passive pathway for the retention and accumulation of nutrients and perfluoroalkyl and polyfluoroalkyl substances (PFAS) present in treated wastewater (TWW). This two-year field-scale study investigated the accumulation of PFAS and nutrients in three native wetland species in a lagoon setting. During the plant establishment period and despite measurable nutrient and PFAS uptake in plant tissues, their removal from the water was limited due to short residence times (∼10–12 h). The highest nutrient accumulation in shoots was observed in Phragmites australis (0.14 g N/m2/day and 0.02 g P/m2/day), which showed the highest biomass (12.1 g/m2/day). Phragmites australis also exhibited the highest PFAS and precursor accumulation in tissues. PFAS removal improved after plant establishment, and the daily removal rate for PFAS (based on PFAS accumulation in plant tissue and sediment) was 240 ng/m2/d. Overall, CFWs show promise as a passive, modular solution for PFAS reduction in TWW, particularly after root system development and biofilm formation. However, long-term monitoring across multiple growth and harvest cycles and assessing the contribution of other mechanisms (such as sorption to growth media and accumulation in biofilms) are required to evaluate the CFW system sustainability under varying environmental conditions.

Metabolic-associated liver disease is a growing public health crisis, with phenotypes from fatty liver to steatohepatitis, previously known as NASH (Non-Alcoholic SteatoHepatitis) and currently rebranded as MASH (Metabolic dysfunction-Associated SteatoHepatitis). Dysfunction in liver metabolism can progress to liver fibrosis, end stage cirrhosis and death. MASH (NASH) is associated with an increased risk of cardiovascular disease, elevation in serum lipids and Type 2 Diabetes Mellitus. There is now a US-approved drug to treat patients with NASH (MASH) under the FDA Accelerated Approval Pathway, which requires follow-up outcome studies to confirm clinical benefit or risk drug withdrawal by the agency. Despite extra-hepatic factors that contribute to MASH and complicate clinical trial design, reorganization of the FDA drug premarket review divisions, improvements to agency policies and procedures, as well as updates to the US Food, Drug & Cosmetic Act (FD&C Act) upon which FDA regulation is based, have provided new agency tools that facilitated such a drug approval to address the profound unmet medical need for patients with this metabolic-based liver disease. There is reason for hope that continued evolution of the regulatory process will lead to additional drug approvals, as well as the ability for clinical trial endpoints studying MASH treatments to include both liver-based and traditional metabolic measures, independent of the specific FDA review division. This initial NASH/MASH FDA approval has also opened the door for initiation of Combination Clinical Trials, where the approved drug is paired with an experimental drug with a different mechanism of action, to increase overall efficacy and potentially minimize risks. It is envisioned that future treatment of NASH/MASH will mirror what is currently observed with Type 2 Diabetes Mellitus practice patterns, where multiple drugs with different mechanisms of actions are used to optimize treatment benefit/risk in the selected patient populations.

Abstract Among the longest Antarctic biological time series is that of Adélie penguin Pygoscelis adeliae population size at Cape Royds, 1955 to the present. Demographic trends over the 66 years fall into five periods: 1) decrease then recovery due to control of tourism from McMurdo Station/Scott Base; 2) further increase responding to the removal of > 20 000 trophically competing Antarctic minke whales Balaenoptera bonaerensis from the colony's wintering area; 3) stabilization but not decrease upon the ban of whaling in 1982, and whale recovery, owing to increased winds facilitating McMurdo Sound Polynya presence (easier ocean access during nesting); 4) decrease in 2001–2005 when two mega-icebergs, B15A/C16, opposed the wind effect by increasing sea-ice cover, thus limiting ocean access; and 5) after iceberg departure, minimal recovery due to the increased velocity of the wind-generated Ross Gyre reducing penguin breeding probability. A multivariant model using 1998–2018 data confirmed the roles of gyre speed (negative) and open water (positive) in colony growth. Additional negative influence came from high nest predation by south polar skuas Stercorarius maccormicki, reducing chick production, as well as perhaps increased trophic competition from nearby Weddell seals Leptonychotes weddellii. Clearly, long time series increase our understanding of penguin population dynamics responding to a complexity of factors.

Urbanization is a leading cause of global biodiversity loss, yet cities can provide resources required by many species throughout the year. In recognition of this, cities around the world are adopting strategies to increase biodiversity. These efforts would benefit from a robust understanding of how natural and enhanced features in urbanized areas influence various taxa. We explored seasonal and spatial patterns in occupancy and taxonomic richness of birds and pollinators among office parks in Santa Clara County, California, USA, where natural features and commercial landscaping have generated variation in conditions across scales. We surveyed birds and insect pollinators, estimated multi‐species occupancy and species richness, and found that spatial scale (local, neighborhood, and landscape scale), season, and urban sensitivity were all important for understanding how communities occupied sites. Features at the landscape (distance to streams or baylands) and local scale (tree canopy, shrub, or impervious cover) were the strongest predictors of avian occupancy in all seasons. Pollinator richness was influenced by local tree canopy and impervious cover in spring, and distance to baylands in early and late summer. We then predicted the relative contributions of different spatial scales to annual bird species richness by simulating “good” and “poor” quality sites based on influential covariates returned by the previous models. Shifting from poor to good quality conditions locally increased annual avian richness by up to 6.8 species with no predicted effect on the quality of the neighborhood. Conversely, sites of poor local and neighborhood scale quality in good‐quality landscapes were predicted to harbor 11.5 more species than sites of good local‐ and neighborhood‐scale quality in poor‐quality landscapes. Finally, more urban‐sensitive bird species were gained at good quality sites relative to urban tolerant species, suggesting that urban natural features at the local and landscape scales disproportionately benefited them.

Cloud computing has created a dramatic change in the banking sector. It is now possible to do cost-efficient, scalable, and high-performance online transactions using the applications of cloud computing. In addition to improving data storage, processing speed, and security, cloud computing reduces costs used in infrastructure. High latency, security risks, and compliance issues mar the traditional banking systems. These limitations made traditional banking inefficacious for recent financial applications such as High-Frequency Trading. This paper proposes a secure and efficient cloud-based high frequency trading (HFT) system based on Lattice-Based Post-quantum Cryptography (LBPQC) and Partially Homomorphic Encryption (PHE) for the provision of more secure transactions. The system minimizes both latency and computational expenses, thereby facilitating real-time executions while improving trade precision by 15% and reducing security breach chances by 20%. AI-driven compliance automation and anomaly detection are also complemented into the model for regulatory compliance. Much higher data protection as well as efficiency in the trade, and threat detection are possible with the proposal that will ensure effective and secure banking infrastructure for any cloud financial activity.

Infrastructure equity is an immediate concern with levees, constituting the backbone of the U.S. protection against flooding. Flooding patterns are exacerbated by anthropogenic climate change in several regions, posing a significant risk to the economy, safety, and well-being of the nation. The evolving risk of flooding is shown to disproportionately affect historically underserved and socially vulnerable communities (HUSVCs). Here we compare the sociodemographic and socioeconomic composition of leveed and non-leveed U.S. communities and show a substantial overrepresentation of HUSVCs in leveed areas at the state, regional, and national levels. Further, we analyze the proportion of communities designated as “disadvantaged” in leveed versus non-leveed areas, revealing a substantially larger population of disadvantaged communities residing behind levees. Our analyses show that nationally, Hispanic are the most overrepresented population in leveed areas yielding a disparity percentage of 39.9%, followed by Native American (18.7%), Asian (17.7%), and Black (16.1%) communities. Communities characterized by low education, poverty, and disability exhibit a disproportionately higher presentation of 27.8%, 20.4%, and 5.4% in leveed areas across the U.S. In 43 states, disadvantaged communities are overrepresented behind levees, with a national disparity percentage of 40.6%. At the regional level, the highest disparity was observed in the Northeast (57.3%), followed by the West (51.3%), Southeast (38%), Midwest (29.2%), and Southwest (25%). The findings can enable decision- and policy-makers to identify hotspots within HUSVCs that need to be prioritized for enhancing the integrity and climate adaptation of their levee systems.

Introduction Chemsex is the use of methamphetamine or other substances to enhance sexual experiences, and is most often associated with sexual minority men. Within the chemsex literature, questions of sexual violence emerge due, in part, to ambiguity about what constitutes consent within sexualized environments with co-occurring substance use. Methods To understand the context in which sexual violence occurs, data from an online survey of sexual and gender minority Texans were analyzed using bivariate and logistic regression (N = 1273), and qualitative interviews with substance-using sexual minority men from a separate sample were thematically analyzed (N = 22). Results Among survey participants, 12.8% experienced a form of sexual violence (10.1% experienced intimate partner violence and 7.6% experienced sexual assault). When participants were categorized based on past year substance use and sex party attendance, 48.0% of participants who used drugs and attended sex parties (a proxy for chemsex) experienced sexual violence (41.6% experienced intimate partner violence and 41.0% experienced sexual assault). When variables statistically significant at the bivariate-level were entered into logistic regression models, participants in the chemsex category were 12.5 [95% CI: 6.9, 22.8] times more likely to experience sexual violence. Substance-using sexual minority men experiencing sexual violence describe situations in which consent is difficult to revoke and sexual exploitation is likely to occur. Discussion Studies which more deeply explore the relationship between sexual and relationship violence and chemsex among sexual and gender minorities are needed. Particularly, the notion of consent needs further conceptualization in the context of drug use and sex parties. Highlights Measures of recent substance use and sex party attendance were combined to create a proxy measure for chemsex, which is the use of substances to enhance sexual experiences. Substance-using sexual and gender minorities engaging in chemsex were at increased risk of sexual violence. In addition to engaging in chemsex, variables associated with an increased odds of sexual violence among sexual and gender minorities were younger age, having a non-monosexual sexual identity, and receiving a mental health diagnoses. Studies on sexual and gender minorities engaging in chemsex should be developed to further explore sexual exploitation.