HNO Bad Bramstedt

The box tree pyralid moth ( Cydalima perspectalis ), which originates from Asia and has been introduced to Europe in 2006, has now infested several countries and continents outside its natural distribution. This herbivore is specialized on Buxus spp. and has destroyed not only many ornamental plantings, which are often of historical value, but also boxwood in its natural range, where it is often part of certain forest types. To date, no effective natural enemies are known, and plantings can only be saved by frequent insecticide applications, while natural boxwoods are threatened or have already gone extinct after massive outbreaks of this pest. During a monitoring in 2025, we discovered a parasitoid population in one of the first infested natural Buxus spp. stands in Europe, the boxwood forest near Grenzach-Wyhlen, Germany. According to our data, this Campoplegine larval parasitoid, Eriborus sp., is not native, but may have been accidentally introduced in the years after the introduction of its host nearby.

Individuals with body dysmorphic disorder (BDD) experience a discrepancy between their own and others’ perception of their physical appearance. This discrepancy indicates biased body representations. BDD is associated with distortions in cognitive-affective and perceptual body image, such as high body dissatisfaction or aberrant visual processing. Body representations are also used for movements and actions (e.g., symptom behavior). These aspects of action-oriented body representations have not been examined yet. The aim of the current study was to investigate general mental rotation and mental rotation of body versus non-body targets to capture such action-related representations. Sixty-three individuals ( n = 35 BDD participants, and n = 28 mentally healthy controls [HC]) were included and performed two mental rotation tasks of non-body and body-stimuli. The results revealed higher mental rotation accuracy in the HC versus BDD group ( t (60.57) = 2.61, p = .011, d = .64) in a paper-pencil task with non-body stimuli (i.e. digits) but no significant group ( F (1, 61) = 0.21, p = .650, ω 2 = .000) or group x stimulus effects in a computerized reaction-time task with body- and non-body stimuli. Bayes Analyses were used to assess the strength of evidence for absence of hypothesized specific effects. Although the conclusion should be interpreted cautiously given methodological factors related to task and participant characteristics, the findings suggest that potential distortions in action-related body representations in BDD may not occur on a general body-related level. They may rather be body part-dependent and warrant further investigation, particularly in relation to disorder-relevant body regions. • Action-oriented body representations were investigated in BDD using mental rotation • Mental rotation of body vs. non-body stimuli dissociates motor from visual imagery • Mental rotation accuracy of digits was lower in the BDD- versus no-BDD group. • No general body-related mental rotation deficits were found in BDD.

BackgroundIn clinical practice and research, self-report instruments are frequently used for assessing the severity of borderline personality disorder (BPD) symptomatology experienced by men and women. Men with BPD are often underrepresented in samples used to evaluate self-report questionnaires. Measurement invariance (MI) is used to examine whether self-report questionnaires determine the same latent construct across groups or varying conditions (e.g., measurement occasions).MethodsThe present study investigated measurement invariance for two self-report measures of BPD features: the Borderline Symptom List (BSL-23) and the Impulsivity and Emotion Dysregulation Scale (IES-27). An inpatient sample of N = 3507 individuals (n = 560 males) was used to test for measurement variance between males and females, and over time from pre- to post-treatment.ResultsConfirmatory factor analysis results supported a unidimensional structure for the BSL-23 and a three-factor model for the IES-27. Both instruments were found to be measurement invariant with regard to sex and time.ConclusionsThe results suggest that the BSL-23 and IES-27 can be used to assess BPD symptoms in men and women, as well as to assess treatment effects at admission and at the end of treatment.

The aim of this study was to develop and psychometrically validate a self-report instrument to assess (1) competencies, (2) needs, and (3) satisfaction among youth transitioning from pediatric to adult rheumatology. The Transition-KompAZ was developed in several steps with conceptual and psychometric analyses. To test its psychometric properties, the instrument was administered to adolescents and young adults (AYAs; 16-25 years) with inflammatory rheumatic diseases before (group 1) or after (group 2) transfer to adult rheumatology. A 2-factor, higher-order confirmatory factor analysis (CFA) model was applied to test the hypothesized factor structure. Internal consistency was estimated using the approach of Raykov with the factor loadings and error variances estimated in the CFA. Spearman rank correlation coefficients were used to assess construct validity. The Transition-KompAZ includes the following modules: (1) competencies in transition (knowledge, self-management), (2) needs (healthcare services, information), and (3) satisfaction (general, transitional care). A total of 173 AYAs (group 1: n = 86; group 2: n = 87) from 12 rheumatology sites completed the Transition-KompAZ. It showed good model fit (comparative fit index > 0.9; Tucker-Lewis index > 0.9; weighted root mean square residual < 0.9) with good internal consistency. The instrument demonstrated moderate-to-good construct validity and good test-retest reliability. The Transition-KompAZ appears to be a reliable tool for assessing important dimensions of transition. It may support a structured and individualized transition, as well as the evaluation of transition services. However, further studies are required to assess its predictive value in terms of transfer readiness and successful transition.

Einleitung Die Anforderung an Verfahren zur Therapieforschung bei Hyperakusis (HK) hat zugenommen. Der Geräuschüberempfindlichkeits-Fragebogen GÜF (Nelting & Finlayson 2004) sowie der Hyperakusis Questionnaire HQ (Khalfa et al. 2002) sind ungenügend valide. In beiden finden sich teils unpräzise Items. Der HQ ist ohne jegliche Instruktion und Quartile.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that is characterized by hyperferritinemia, cytopenia, disseminated intravascular coagulopathy and functional disorders of the liver and the central nervous system. The term macrophage activation syndrome is predominantly used for secondary HLH in the context of autoimmune diseases (e.g., systemic juvenile idiopathic arthritis). In addition, malignancies and genetic inborn errors of immunity can predispose to the development of HLH. Infections (e.g., Epstein-Barr virus) in turn represent possible triggers of an acute episode. Due to the unspecific manifestation of the disease, a systematic evaluation of the organ systems is recommended in the clinical and laboratory analytical clarification of hyperinflammatory syndromes. In general, the treatment should be carried out by a multidisciplinary team with expertise in rheumatology, hematological oncology, infectious diseases and intensive care medicine. The primary treatment of HLH usually consists of glucocorticoids and in cases of a rapid deterioration of the condition anakinra (interleukin 1 block) and intravenous immunoglobulins can be employed. Treatment of the underlying disease should be consequently carried out in parallel, together with antimicrobial treatment.

Das Hughes-Stovin-Syndrom (HSS) ist eine entzündliche Systemerkrankung unklarer Genese, die inzwischen dem Spektrum des Behçet-Syndroms (BS) zugeordnet wird. Wegweisende Befunde sind rezidivierende Thrombosen des venösen Systems und oberflächliche Thrombophlebitiden in Kombination mit beidseitigen Pulmonalarterienaneurysmen (PAA). Die Pulmonalisangiographie mittels Computertomographie ist von entscheidender diagnostischer Bedeutung, um die (entzündliche) Beteiligung der Pulmonalarterien darzustellen. Die Therapie des HSS orientiert sich an den Empfehlungen der European Alliance of Associations for Rheumatology (EULAR) für das BS und sieht primär eine Immunsuppression mit Cyclophosphamid und Glukokortikoiden vor. Neben einer medikamentösen Therapie sollte eine interventionelle Versorgung der PAA evaluiert werden. Eine spontane PAA-Ruptur muss auch bei Remission der Erkrankung und/oder deutlicher Regredienz des PAA-Durchmessers aufgrund einer fragilen Gefäßarchitektur bedacht werden.

Gastroesophageal reflux disease (GERD) occurs frequently in patients with SSc. We investigated whether the presence of GERD and/or the use of anti-acid therapy, specifically proton-pump inhibitors (PPIs), are associated with long-term outcomes, especially in SSc-associated interstitial lung disease (SSc-ILD). We retrospectively analysed patients with SSc and SSc-ILD from the German Network for Systemic Sclerosis (DNSS) database (2003 onwards). Kaplan-Meier analysis compared overall survival (OS) and progression-free survival (PFS) in patients with GERD vs without GERD (SSc and SSc-ILD), and PPI vs no PPI use (SSc-ILD only). Progression was defined as a decrease in either percentage predicted forced vital capacity of ≥10% or single-breath diffusing capacity for carbon monoxide of ≥15%, or death. It was found that 2693/4306 (63%) registered patients with SSc and 1204/1931 (62%) with SSc-ILD had GERD. GERD was not associated with decreased OS or decreased PFS in patients in either cohort. In SSc-ILD, PPI use was associated with improved OS vs no PPI use after 1 year [98.4% (95% CI: 97.6, 99.3); n = 760 vs 90.8% (87.9-93.8); n = 290] and after 5 years [91.4% (89.2-93.8); n = 357 vs 70.9% (65.2-77.1); n = 106; P < 0.0001]. PPI use was also associated with improved PFS vs no PPI use after 1 year [95.9% (94.6-97.3); n = 745 vs 86.4% (82.9-90.1); n = 278] and after 5 years [66.8% (63.0-70.8); n = 286 vs 45.9% (39.6-53.2); n = 69; P < 0.0001]. GERD had no effect on survival in SSc or SSc-ILD. PPIs improved survival in patients with SSc-ILD. Controlled, prospective trials are needed to confirm this finding.