Hamari Chemicals (Japan)

Post-COVID-19 Vaccination Syndrome (PCVS) refers to persistent, multisystemic symptoms developing after SARS-CoV-2 immunization. We established a nationwide registry across 14 Japanese outpatient clinics and analyzed 179 “clinically definitive” cases from 279 enrollees (December 2020–August 2023). All adverse events (AEs) were coded using MedDRA/J Preferred Terms and System Organ Classes; severity followed NCI-CTCAE V5.0. The cohort (66.5% female; mean age 59 years) experienced 493 AEs (median 2 per patient, range 1–29). Three System Organ Classes—General Disorders (29.2%), Nervous System Disorders (22.3%), and Musculoskeletal Disorders (10.1%)—accounted for 61.7% of events; fatigue, brain fog, dizziness, and extremity pain predominated. While 69.4% of AEs arose within 90 days post-vaccination, 12.4% appeared ≥ 360 days later. Severe AEs (≥ Grade 3) occurred in 14.6% of patients; overall improvement was 65.1%, leaving 29.4% unresolved. A provisional phenotype classification combining symptom patterns, onset timing, and severity identified high-risk subgroups with > 60% non-recovery rates. These findings underscore the need for enhanced post-vaccination surveillance systems and comprehensive care frameworks specifically tailored to address the protean manifestations and persistent nature of PCVS.

Abstract Dynamic thermodynamic resolution of amino acids (AAs) using Ni(II) chiral Schiff bases is one of the simplest and most efficient methods to obtain optically active AAs. A comparison of the reactivity of 36 rac‐AAs with the Ni(II) complex revealed that this method can be easily applied to dynamic thermodynamic resolution and S/R interconversion of AAs with unprotected active functional groups. It can also be really applied for the side‐chain modification of AA derivatives with active functional groups on the Ni(II) complex. Furthermore, the antimicrobial activities of the synthesized Ni(II) complexes were evaluated, and the Ni(II) complexes [(S,S)−3 g, (S,S)−3 h, and (S,S)−3 i] showed remarkable antibacterial activity against Micrococcus luteus, a Gram positive bacterium.

Boron neutron capture therapy (BNCT) with p-boronophenylalanine (BPA) is expected to have less effect on the decrease in normal bone strength than X-ray therapy. However, the compound biological effectiveness (CBE) value necessary to convert the boron neutron capture reaction (BNCR) dose into a bioequivalent X-ray dose has not been determined yet. The purpose of this study was to evaluate the influence of BNCT on normal bone in mice and to elucidate the CBE factor. We first searched the distribution of BPA in the normal bone of C3H/He mice and then measured the changes in bone strength after irradiation. The CBE value was determined when the decrease in bone strength was set as an index of the BNCT effect. The 10B concentrations in the tibia after subcutaneous injection of 125, 250 and 500 mg/kg BPA were measured by prompt gamma-ray spectroscopy and inductively coupled plasma (ICP)-atomic emission spectrometry. The 10B mapping in the tibia was examined by alpha-track autoradiography and laser ablation-ICP-mass spectrometry. The 10B concentration increased dose-dependently; moreover, the concentrations were maintained until 120 min after BPA administration. The administered 10B in the tibia was abundantly accumulated in the growth cartilage, trabecular bone and bone marrow. The bone strength was analyzed by a three-point bending test 12 weeks after irradiation. The bending strength of the tibia decreased dose-dependently after the irradiation of X-ray, neutron and BNCR. The CBE factor was obtained as 2.27 by comparing these dose-effect curves; the value determined in this study will enable an accurate dosimetry of normal bone.

Abstract Aposiopesis, »the sudden breaking off of what is being said (or written)«, is not simply a rhetorical figure but a linguistic device of the ellipsis of the main clause or the sentence nucleus. The speaker conveys »feelings of haste, urgency, and anxiety«, as in the cases of Hannah (1Sam 1:22) and Tamar (2Sam 13:16). The omitted phrase or clause is usually negative. Further Examples: 1) 2Sam 23:17 Is it [not] the blood of the men who went at the risk of their lives? 2) 2Sam 21:1 due to Saul and the bloody house Textual omission and conversational ellipsis need to be carefully distinguished.

Square pole implant models of Ti-6Al-4V were fabricated by selective laser melting (SLM) and osteoconductivity was investigated on their surface. The models have 3 types of surfaces; top surface, side surface, and polished surface. The surfaces have each different surface roughness and the influence of the roughness on the osteoconductivity was observed in-vivo experiment. The models were implanted in rat femurs and observed after 2 and 8 weeks. We observed the amount of hard tissue produced on the surfaces in the cut-off cross section of the femurs with the model by means of an optical microscope and bone-implant contact ratio (RB-I) was evaluated. As the result, in the case of 2 weeks-raised rats, the RB-I of the polished surface was the highest of all surfaces. The RB-I of the surface was however the lowest and that of the top surface was the highest in the case of 8 weeks-raised rats.

Here we describe an early Carboniferous brachiopod fauna from the middle part of the Arakigawa Formation in the Hongo area, Hida Gaien Belt, central Japan. The Hongo fauna consists of six species in five genera: Pugilis sp., Marginatia sp., Fluctuaria undata (Defrance), Fluctuaria sp., Actinoconchus sp., and Imbrexia sp. The fauna is identified as late Visean in age, thus correlating the middle part of the Arakigawa Formation with the upper Visean. Palaeo-biogeographically, the Hongo fauna exhibits affinities with early Carboniferous brachiopod faunas of northwestern China (Xinjiang) and northeastern Japan (South Kitakami Belt). The fauna probably belonged to the North China Province, which covered a broad area between the North China Block and the Siberian Block (i.e., the Central Asian Orogenic Belt, CAOB) during the late Visean. The Hida Gaien Belt, including the Hongo area, was likely located in the CAOB during the late Visean. Similarities between the lithology and fauna of the Arakigawa Formation and those of the Carboniferous formations of the South Kitakami Belt provide positive evidence of a tectonic connection between the Hida Gaien and South Kitakami belts.