Hauser (United States)

In this chapter, we study voter preferences for different social democratic programmatic strategies. In line with the theoretical framework of the volume, we suggest that there are four different strategies social democratic parties could currently pursue: Old Left, New Left, Centrist or Left National. In original surveys conducted in 6 European countries (Austria, Denmark, Germany, Spain, Switzerland and Sweden), we present these four strategies to respondents in the form of tabular vignettes. Evaluations of these vignettes are used to examine which programmatic strategies resonate with, on the one hand, the general electorate, and, on the other hand, the potential social democratic electorate. We also study support for the different programmatic strategies across subgroups of voters, and we analyze the determinants of voters’ choice between particular social democratic strategies and matched competitor party programs. Our findings show that while in the overall electorate, Centrist Left and Left National programmatic profiles enjoy high levels of support, potential social democratic voters on average more strongly support Old Left and New Left programs. We find that from the perspective of voters, there might be less of a trade-off between “redistribution and recognition” policies than public debates would have us think. In line with these findings, we show that choices between social democratic parties and their direct competitors are responsive to programmatic supply within the left bloc. However, the choice between social democratic parties and parties of the Right is much less strongly affected by social democratic ositioning.

Biopharmaceuticals have revolutionized the field of medicine in the types of active ingredient molecules and treatable indications. Adoption of Quality by Design and Process Analytical Technology (PAT) frameworks has helped the biopharmaceutical field to realize consistent product quality, process intensification, and real-time control. As part of the PAT strategy, Raman spectroscopy offers many benefits and is used successfully in bioprocessing from single-cell analysis to cGMP process control. Since first introduced in 2011 for industrial bioprocessing applications, Raman has become a first-choice PAT for monitoring and controlling upstream bioprocesses because it facilitates advanced process control and enables consistent process quality. This paper will discuss new frontiers in extending these successes in upstream from scale-down to commercial manufacturing. New reports concerning the use of Raman spectroscopy in the basic science of single cells and downstream process monitoring illustrate industrial recognition of Raman’s value throughout a biopharmaceutical product’s lifecycle. Finally, we draw upon a nearly 90-year history in biological Raman spectroscopy to provide the basis for laboratory and in-line measurements of protein quality, including higher-order structure and composition modifications, to support formulation development.Graphical abstract

Introduction: Splenic abscess is a rare and highly morbid extracardiac manifestation of infective endocarditis (IE) and has only been described in small case series in the literature. Emergency surgeons are often consulted for splenectomy; however, the optimal timing (before or after valve) of this intervention remains unclear. We hypothesized that definitive valve intervention, prior to splenectomy, would lead to superior patient outcomes.

Abstract Ein neuartiges, auf funktionalisiertem, nanoporösen Graphen basierendes Verfahren zur Abtrennung chiraler Moleküle wird vorgestellt. Auf Dichtefunktionaltheorie basierende Computersimulationen zeigen, dass durch Anhaften eines chiralen “Türsteher”‐Moleküls an den Porenrand einer Form des Enantiomers der Eintritt verweigert wird, während sein Spiegelbild passieren kann.