Health Commission of Anhui Province

Hypertension (HTN) is a mitochondrial and metabolic disease. However, cause-effect connections between mitochondrial dysfunction and HTN remains uncharted. we focused on mitochondria-related genes, identifying potential causal-genes-relevant blood pressure (BP) using mitochondria-related genome-wide Mendelian randomization (MR). Through the summary statistics from cis-expression quantitative trait loci (cis-eQTL) datasets (human blood and artery), mitochondrial transcription factor A (TFAM), and genome-wide association studies (GWAS) datasets of BP indices (systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP], and mean arterial pressure [MAP]) and HTN. we conducted a MR analysis to explore the potential causal relationship between mitochondrial-related genes and the BP indices, HTN. Sensitivity analysis and Bayesian colocalization were employed to validate this causal relationship. In aorta, HIBCH expression was negatively associated with SBP; OCIAD1 expression was positively associated with MAP. In tibial artery, HIBCH expression was negatively associated with SBP; OCIAD1 expression was positively associated with SBP, PP, and MAP; SLC25A37 was positively associated with MAP. In blood, LACTB expression was negatively associated with SBP, PP, and MAP; OCIAD1 expression was negatively associated with SBP and PP; and MTX1 expression was negatively associated with MAP. HARS2 expression was positively associated with SBP and PP; RAB24 and PRELID1 expression was positively associated with DBP; and NME6 expression was positively associated with SBP and DBP. In conclusion, the regulation of blood pressure correlates with mitochondria-related genes (HIBCH, SLC25A37 and OCIAD1 in artery; LACTB, OCIAD1, MTX1, HARS2, RAB24, PRELID1 and NME6 in blood). This study provides scientific evidence for specifically regulating BP phenotypes.

Objective:‌ To explore the association between dietary inflammatory index (DII) and depression and their individual/combined mortality effects in U.S. adults. ‌Methods ‌ NHANES 2013–2018 cohort data were analyzed. DII scores were calculated from 24-hour dietary recalls; depression was assessed via Patient Health Questionnaire-9 (PHQ-9). Logistic regression and restricted cubic spline (RCS) analyses examined DII-depression associations. Cox regression and Kaplan-Meier curves evaluated mortality risks. ‌Results ‌ A total of 12,521 participants were finally included in the final analysis. Logistic regression and RCS analyses revealed a dose-response relationship between higher DII and depression risk (p < 0.001). Over 6.82-year median follow-up, depression was independently associated with increased all-cause mortality (HR:1.42, 95% CI:1.11–1.82), particularly in adults age <60 (HR:3.01, 95% CI: 1.94–4.65), BMI < 25 kg/m2 (HR:2.40, 95% CI: 1.58–3.65), and nonsmokers (HR:2.61, 95% CI: 1.77–3.85). Each unit DII increase raised all-cause mortality by 7% (HR:1.07, 95% CI:1.02–1.12) and cardiovascular diseases (CVD) mortality by 12% (HR:1.12, 95% CI:1.02–1.22), with stronger effects in those with BMI ≥ 25 (HR:1.11,95% CI:1.05–1.18) and smokers (HR:1.14,95% CI:1.05–1.23). No significant DII-depression interaction on mortality was found. ‌Conclusion ‌ A higher DII score was associated with increased depression risk in U.S. adults. Depression and high DII scores elevated all-cause mortality, but these impacts varied with age, BMI, or smoking status. These findings highlight nutrition-mental health links for targeted prevention.

The objective of the study was to compare the anatomical and histological features of posterior lingual glands among Chinese tree shrews, mice, and humans, providing morphological evidence for evaluating the tree shrew as a biomedical model.Paraffin sections of lingual tissues from Chinese tree shrews (n=5), mice (n=5), and humans (n=3) were analyzed using hematoxylin-eosin (HE) and alcian blue staining.Morphological structures, including vallate papillae, Von Ebner's glands (deep portion of the posterior lingual glands/gustatory glands), and Weber's glands (superficial portion of the posterior lingual glands/glands of root of tongue), were systematically examined.Chinese tree shrews exhibited V-shaped vallate papillae arrangement, resembling humans but differing from mice.The deep portion of the posterior lingual glands in all three species were pure serous glands (alcian blue-negative), though mice lacked striated ducts.The deep portion of the posterior lingual glands in tree shrews and humans were pure mucous glands (alcian blue-positive), draining via short ducts into mucosal surfaces, while murine the superficial portion of the posterior glands were mixed type and opened into tongue crypts.The anatomical and histological similarities between Chinese tree shrews and humans in posterior lingual gland structures, combined with its utility in studying human-specific diseases, support the tree shrew as a valuable model for investigating pathogenesis of lingual gland-related disorders.

BackgroundWith the acceleration of population aging, the problem of obesity among older adults is becoming increasingly prominent, representing a major public health problem affecting the health of older adults. In recent years, socioeconomic status(SES) has become a hotspot in research into the mechanisms influencing obesity(OB). However, few studies have explored the process and mechanism of action by which SES affects obesity.MethodsThe sample consisted of 5,576 older adults (≥ 65 years), from a large cross-sectional study conducted in Deyang City, China. Different factors associated with OB in older adults were assessed using χ2 test. Pearson correlation analysis and the SPSS function “PROCESS macro” were used for correlation and serial multiple mediation analysis, respectively, to analyze the relationship between SES and OB, and the mediating role of social support and sleep quality.ResultsThe prevalence of obesity among older adults aged ≥ 65 years was 11.05%. The risk of obesity was higher among older adults who were women, relatively young, less educated, non-smokers, or with chronic diseases. SES directly affects obesity (SE = 0.187, 95% CI: 0.105, 0.270), accounting for 88.21% of the total effect. Additionally, social support and sleep quality were found to mitigate the negative effect of high SES on obesity (SE = − 0.025, 95% CI: − 0.045, − 0.006), resulting in a suppressing effect that accounts for 11.79% of the total effect.ConclusionsGreater social support and sleep quality lower the obesity risk associated with SES in older adults. Therefore, targeted prevention, control, and intervention measures, such as increasing social support and improving sleep quality, can be applied based on the characteristics of older adults of different socioeconomic statuses to minimize the socioeconomic status-associated obesity risks and thus achieve the goal of reducing obesity.

BackgroundThe relationship between personal health literacy and health outcomes is clear, but the role of health literacy environments is often overlooked. This study examined associations between personal health literacy, school health literacy environments and health outcomes among schoolteachers.MethodsA cross-sectional study was conducted among 7,364 schoolteachers in Zhengzhou, China. Personal health literacy was measured by the Health Literacy Population Survey 2019–2021 (excellent/sufficient/problematic/inadequate) and school health literacy environments were measured by the Organisational Health Literacy of School Questionnaire (supportive/less supportive). Health outcomes included health status (poor/good), health-compromising behaviours (yes/no), health service use (yes/no), and healthcare cost (≥RMB 1,000/ &amp;lt;RMB 1,000).ResultsOver half of teachers had inadequate or problematic health literacy. Teachers with inadequate health literacy had higher odds of poor health status, health-compromising behaviour, health service use, and high healthcare cost than those with excellent health literacy. Similarly, teachers who perceived less supportive school health literacy environments had higher odds of poor health outcomes.ConclusionBoth personal health literacy and school health literacy environments are important to schoolteachers' health outcomes. Educational programs and organisational change are needed to improve personal health literacy and school environments to improve schoolteachers' health and wellbeing.

The incidence trend of breast molecule subtypes was unclear. There was not quantified risk by subtype with the second primary malignancies (SPMs) and limited evidence about the risk factors for developing SPMs in first primary breast cancer(FPBC). Data from 18 SEER registries were used to identify FPBC, which were randomly selected for training and validation sets. The SPMs information of breast cancer survivors in Hebei were also collected to compare the distribution with SEER. Univariate and multivariate analysis were performed to explore the risk factors and integrated to the establishment of nomogram and risk stratification model. There was a decreased trend for TNBC, but an increased trend for Luminal A. The median survival months were 46, 46, 46 and 44 for Luminal A, Luminal B, HER2 enriched and TNBC, with the median latency time were 39, 39, 40 and 41.0 months, respecitvely, The cumulative incidence rates(CIR) of SPMs were 2.61%, 2.30%, 2.21% and 2.84%. Age at diagnosis, clinical lymph node status, radiotherapy and subtypes were independent risk factors for SPMs. A predict nomogram was established with the AUC of 0.682 and 0.679 for three- and five- year incidence risk in training set. Patients were divided into the low-risk (31.94%), intermediate-risk (51.83%) and high-risk (16.23%) groups by risk stratification model. The first common SPMs was second breast cancer in both SEER and Hebei cohort, the second and third rank SPMs were lung and gynecological cancer in SEER, but presented the opposite result in Hebei. The incidence rates and SPMs of subtypes were difference. The high risk individuals could be identified by risk stratification model, who need more closely followed up by Clinicians.

Cilostazol is an antiplatelet drug and is used for stroke prevention and symptomatic peripheral vascular disease. Studies have reported the effects of cilostazol on cognitive function, but the results are inconsistent and have not been systematically assessed. We systematically searched the PubMed, Embase, and Cochrane databases for relevant clinical studies. The primary outcome was the change in Mini-mental State Examination (MMSE) scores from baseline to the last available follow-up. The secondary outcome was dementia risk. Mean differences and 95% confidence intervals (CIs) were calculated for combining MMSE scores, and the pooled odds ratios and 95% CIs were used to calculate the association between use of cilostazol and dementia risk. Overall, 8 eligible studies met inclusion criteria were pooled in meta-analysis. Though with a trend toward favoring cilostazol, the pooled changes in MMSE scores from baseline showed no significant difference in mild cognitive impairment and dementia patients (mean differences 1.02, 95% CI -0.53 to 2.57, P = .195). For secondary outcome, cilostazol reduced the risk of dementia in patients without prior history of dementia (pooled odds ratios 0.90; 95% CI 0.87 to 0.92; P = .000). These results suggest the potential for cilostazol treatment in the suppression of cognitive decline and prevention of progression to dementia. However, the lack of blinding in most studies is likely to cause an overestimation of the effect sizes, and further well-designed studies are also needed.