Hematology & Oncology Consultants

Parkinson’s Disease (PD) is a common neurodegenerative disorder characterized primarily by motor symptoms such as bradykinesia, muscle rigidity, and resting tremor. It is now broadly accepted that these motor symptoms frequently co-occur with cognitive impairments, with deficits in working memory and attention being among the most common cognitive sequalae associated with PD. While these cognitive impairments are now recognized, the underlying neural dynamics and precise regions involved remain largely unknown. To this end, we examined the oscillatory dynamics and interregional functional connectivity that serve working memory processing in a group of un-medicated adults with PD and a matched group without PD. Each participant completed a high-load, Sternberg-type working memory task during magnetoencephalography (MEG), and we focused on the encoding and maintenance phases. All data were transformed into the time-frequency domain and significant oscillatory activity was imaged using a beamforming approach. Phase-coherence (connectivity) was also computed among the brain sub-regions exhibiting the strongest responses. Our most important findings were that un-medicated patients with PD had significantly diminished working memory performance (i.e., accuracy), and reduced functional connectivity between left inferior frontal cortices and left supramarginal–superior temporal cortices compared to participants without PD during the encoding phase of working memory processing. We conclude that patients with PD have reduced neural interactions between left prefrontal executive circuits and temporary verbal storage centers in the left supramarginal/superior temporal cortices during the stimulus encoding phase, which may underlie their diminished working memory function.

5029 Background: Galeterone is a 1st in class oral small molecule that disrupts androgen receptor (AR) signaling via multi-targeted mechanism of action (1) selective inhibition of CYP17 lyase; (2) ...

The first pediatric descriptions of cyclic vomiting syndrome were provided in the French literature by Heberden in 1806 and in the English literature by Gee in 1882. An association of cyclic vomiting with migraine headaches was reported by Whitney in 1898. Described by Liveing in 1873 and Buchanan in 1921, Brams introduced the term “abdominal migraine” in 1922. We present 2 cases of cyclic vomiting syndrome and 3 cases of abdominal migraine in adults and provide a review.