Horse Hospital

In 2025, an outbreak of equine influenza occurred among draft horses at Obihiro Racecourse in Hokkaido, Japan. The number of horses showing clinical signs increased dramatically in April. The proportion affected was significantly higher in 2-year-olds than in older groups. The proportion that developed fever during the outbreak was significantly higher than that observed among Thoroughbreds during the 2007 outbreak. In non-epidemic periods, the geometric mean hemagglutination inhibition antibody titer of 2-year-old draft horses was significantly lower than that of 2-year-old Thoroughbreds. These draft horses had received fewer vaccinations than the Thoroughbreds. Less frequent vaccination likely led to a lower antibody titer and a higher final attack rate in the 2-year-olds and in the overall draft horse population.

Die Leistungsfähigkeit von Hörgeräten hinsichtlich ihrer Verstärkung und Wirksamkeit der Signalverarbeitungs[Ga1] -Features wird maßgeblich durch die Ankopplung an das Ohr bestimmt. Hier ist aus technischer Sicht eine möglichst geschlossene Ankopplung nötig, [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Summary: This study presents two cases of late-onset Post-Traumatic Stress Disorder (PTSD) among survivors of the 2011 Great East Japan Earthquake, tsunami, and nuclear disaster. These cases were observed in Minamisoma City, Fukushima Prefecture, which experienced multiple subsequent disasters, including floods (2019), major earthquakes (2021-2022), and the COVID-19 pandemic (2020-2021). The region underwent mandatory evacuation for over a year following the nuclear disaster, significantly disrupting community structures and social support systems. The cases were documented through clinical observations at a psychiatric practice established in 2016 in Minamisoma City, located within 20km of the Fukushima Daiichi Nuclear Power Plant. Both patients were followed longitudinally from their initial presentation through the recognition and treatment of their PTSD symptoms. Detailed clinical interviews and psychological assessments were conducted throughout the treatment period. Both patients provided written and verbal consent to present their cases in academic settings and publications. Both cases exhibited a pattern of initial over-adaptation during the first few years post-disaster, actively participating in community recovery efforts and displaying apparent resilience. Subsequently, they developed depressive symptoms, leading to psychiatric intervention. Despite receiving treatment, their conditions fluctuated significantly. Several years of therapeutic engagement were required before patients recognized their trauma-related memories and associated symptoms. Retrospective analysis revealed that their initial over-adaptation to post-disaster community needs potentially masked underlying PTSD pathology, complicating early diagnosis and intervention. These cases highlight the importance of recognizing delayed-onset PTSD in disaster survivors, particularly when initial over-adaptation may obscure underlying trauma. The study proposes preventive strategies and screening protocols for similar mental health issues in future disaster scenarios, emphasizing long-term monitoring.

Emergency seizure management in people with intellectual disabilities can be complex. This article discusses the impact of epilepsy on the health and quality of life of people with intellectual disabilities. It explores contemporary approaches to ensuring that people with intellectual disabilities and their support network are meaningfully engaged in managing epilepsy, including through the use of epilepsy management plans, seizure action plans and the promotion of self-management. The article presents a biopsychosocial perspective to emergency seizure management, which promotes shared decision-making and a holistic, respectful approach to care.

El derecho español y el marco jurídico europeo reconocen la relevancia estratégica de la responsabilidad social corporativa (RSC) y la protección del medioambiente como pilares fundamentales para el desarrollo sostenible y la responsabilidad empresarial. Apostar por la RSC y la sostenibilidad ambiental proporciona múltiples ventajas competitivas a las empresas, más allá del mero cumplimiento normativo. En primer lugar, una sólida política de RSC mejora la reputación de la empresa ante consumidores, inversores y la sociedad en general, fortaleciendo la confianza pública y fomentando una mayor lealtad de los clientes. Además, en un mercado cada vez más consciente, los consumidores tienden to preferir marcas comprometidas con prácticas éticas y sostenibles, lo que abre nuevas oportunidades de negocio y facilita el acceso a nuevos segmentos de mercado. Por otro lado, la adopción de políticas responsables en materia ambiental permite a las empresas anticiparse a las exigencias legales, reduciendo significativamente el riesgo de sanciones, multas y daños reputacionales derivados del incumplimiento normativo. En definitiva, integrar la responsabilidad social y la protección ambiental en la estrategia empresarial no solo cumple una función ética y legal, sino que también impulsa el rendimiento financiero a largo plazo. Las empresas españolas que lideran en estos ámbitos consolidan su ventaja competitiva, fortalecen su posicionamiento de marca y contribuyen activamente a un modelo de crecimiento económico más justo y sostenible.

The paper explores the assessments of Russia’s carbon neutrality prospects made by a number of Russian expert groups. It provides a discussion of how decarbonization trajectories should be identified—by using an ensemble of models or by a consortium. The main focus is on the analysis of forecasts of Russia’s energy sector development to 2060 and the assessments of the effects of using carbon pricing mechanisms. The focus is on the latest studies from expert groups published since Russia announced its goal of moving towards carbon neutrality by 2060. The key fork on the roadmaps to carbon neutrality is shown to be Forest Last versus Forest First. The analysis has shown that, while studies of 2060 decarbonization prospects are becoming more plentiful in Russia, not all of them are of adequate quality, and many are extremely conservative.

Per- and polyfluoroalkyl substances (PFAS) are a groupof endocrine-disruptingchemicals, however their effect on pubertal development remains largelyunknown. In this cross-sectional study, we examined associations betweenPFAS exposure and pubertal timing in a cohort of 618 girls aged 6to 16 years from the Bergen Growth Study 2 in Norway, 2016. Serumconcentrations of 19 PFAS were measured, and pubertal developmentwas assessed using several pubertal markers, including ultrasound-assessedbreast development, Tanner staging, pubertal hormone levels, and ageat menarche. We applied quantile g-computation, elastic net, and Bayesianregression to evaluate both combined and individual effects of PFASexposure, in addition to single-pollutant analyses. Higher PFAS concentrationswere significantly associated with later thelarche, pubarche, lowerserum levels of luteinizing hormone, follicle-stimulating hormone,estrone, and estradiol, and later menarche. Among the PFAS analyzed,perfluorooctanesulfonic acid (PFOS) and perfluorodecanoic acid (PFDA)emerged as the key predictors of later pubertal markers. Our resultsindicate that PFAS exposure is associated with later puberty in girls.

Generative AI (Gen AI) has transformed fields including, but not limited to, public safety and healthcare, such as emergency triage systems and diagnostic decision support, through fast decision making and innovative problem solving.However, its reliability is compromised by risks of inaccuracy, or where AI outputs differ from factual truth, and hallucinations, or where entirely fabricated information is generated.In critical functions, such errors could lead to severe consequences such as misdiagnoses, inefficient emergency responses, or misinformation to the public.This review is based on recent studies, government reports, and technical papers to analyze strategies such as human-in-the-loop systems, algorithmic transparency, and real-time error detection to address these risks.These approaches are examined to identify trends and gaps in current practices.Technical, policy, and training solutions to ensure trustworthy AI use in high-stakes scenarios are emphasized, with support provided from research.

Abstract BACKGROUND Low-density lipoprotein receptors (LDLR) are overexpressed in a variety of solid tumors, including glioblastoma (GBM), and are known to play a key role in tumor proliferation and metabolic regulation.-LDLRs are also expressed on the blood-brain barrier (BBB), offering a unique gateway for receptor-mediated delivery of radiopharmaceuticals to intracranial tumors. In this study, we present initial data from eIND on the use of a novel LDLR-targeted imaging agent, ⁶⁸Ga-RMX-VH, in patients with newly diagnosed or recurrent GBM, We will also discuss the selection of the second-generation RMX_VH_PKM, which features modified blood circulation times and improved tumor-targeting properties. METHODS We initiated an open-label, single-dose, eIND-study (#155880) using 68Ga-RMX-VH PET/CT in newly diagnosed or recurrent patients with GBM. The primary objective was to assess the biodistribution and dosimetry of 68Ga-RMX-VH. The secondary objective was to correlate the extent of GBM visualized by contrast-enhanced MRI of the brain with the distribution of 68Ga-RMX-VH PET/CT in the brain, in each subject. A total of 10 GBM subjects have been scheduled for enrollment, with 5 of them enrolled in the dosimetry group. RESULTS We enrolled four patients with glioblastoma (GBM) (3 males, 1 female, aged 58–68 years) who had undergone craniotomy, adjuvant chemotherapy, and/or radiation therapy (XRT) and exhibited disease progression on MRI/CT scans. Pathological evaluation confirmed GBM with MGMT promoter methylation, IDH wild-type status, and EGFR mutation (Ki-67 = 25–60%). PET/CT imaging with ⁶⁸Ga-RMX-VH demonstrated effective targeting of the solid portion of the residual tumor, correlating well with contrast-enhanced regions on MRI or FLAIR. Activity was primarily cleared via the kidneys. These results stimulated our work on the selection of the second-generation RMX-VH-PKM, which has a longer blood circulation time and improved tumor–specific retention, as confirmed in vivo studies. CONCLUSIONS RMX-VH agents effectively target LDLR-overexpressing glioblastoma (GBM), with ⁶⁸Ga- or 203Pb-labeled radiotracer uptake closely aligning with enhanced and FLAIR regions on brain MRI.

Abstract Introduction Three types of oxidative DNA damage ((oxidised guanosine/8OHdG, Single strand breaks (SSBs)/comet assay, Double strand breaks (DSBs)/gammaH2AX)) are becoming tested more frequently in clinical cardiology research (Picture 1). Epidemiology of arterial hypertension /HT/ is not optimal. Purpose To describe systematically the most severe DNA damage in HT (humans, animals, cell-lines). Methods This review on DNA damage in HT was made using multiple databases to search for English-language publications up to June 30, 2022 and the key words: DNA damage, 8OHdG, strand breaks, comet assay, gammaH2AX and HT. Inclusion, exclusion criteria, flow diagram (Picture 1). Results Finally, N=31 studies: (N=15 humans, N=13 animals, N=3 cells) (Picture 1). A total of 902 hypertensive patients (pts): (8OHdG: N=484 pts; SSBs: N=418 pts) and 587 controls (8OHdG: N=384; SSBs: N=203) were included. DNA damage was significantly higher in hypertensive pts than healthy controls (8OHdG 13.1±4.12 vs 6.97±2.67 ng.mg-1 creatinine; P<0.05 and SSBs 26.6±11.0 vs 11.7±4.07 arbitrary units /A.U./; P<0.05) with the average mean differences and 95% confidence limit (MD /95%CL) 7.5 /6.6; 8.6/ ng.mg-1 creatinine for 8OHdG in urine, respectively 14.7 /6.4; 23.0/ A.U. for SSBs in peripheral lymphocytes. Greater DNA damage was observed in more adverse cases (sustained/untreated hypertension 31.4±12.1 vs 14.2±5/35.0±5.0 vs 25.0±5.0; non-dippers 39.2±15.5 vs 29.4±11.1 A.U.; concentric cardiac hypertrophy 43.4±15.4 vs 15.6±5.5; elderly 14.9±4.5 vs 9.3±4.1 ng.mg-1 creatinine; without carvedilol 9.1±4.2 vs 5.7±3.9; with coronary heart disease 0.5±0.1 vs 0.2±0.1 ng.mL-1) (P<0.05) with the average MD /95% CL/ 3.4 /0.8;5.9/ ng.mg-1 creatinine for 8OHdG in urine, respectively 16.1 /12.1; 20.1/ A.U. for SSBs in peripheral lymphocytes. DNA damage correlated strongly positively with serum glycosylated haemoglobin (r=0.670; P<0.05) and negatively with total antioxidant status (r=−0.670 to −0.933; P<0.05). Higher DNA damage (8OHdG, SSBs, DSBs; P<0.05) in HT than in controls was consistently seen also under strictly experimental conditions (animals; cell-lines). Conclusion This is the first review showing systematically that oxidative DNA damage was consistently increased in HT individuals compared to controls (humans, animals, cell-lines) (Ref 1;2). The author believes that this finding can help at least partially fill in the gaps in the evidence, it can be a further piece in the pathophysiological subcellular mosaic (unrepaired harmful DNA in the cytosol when the reparation and defences are exceeded, cytosolic DNA sensors are activated) (Ref 3;5). Thus author believes, that this finding could represent a new therapeutic challenge (DNA damage response substances like a target) (Ref 4;5). First of all, everything must be thoroughly and repeatedly investigated with the caution for pharmacotherapy (Ref 1;2), which can unfortunately affect the results of DNA damage (Ref 1;6).Inclusion, Exclusion; Flow diagram