Hunterdon Medical Center

The Asian longhorned tick (ALT), Haemaphysalis longicornis, is a three-host hard tick native to East Asia. Its opportunistic feeding habits make it an acute agricultural and medical threat, capable of spreading various zoonotic pathogens. An affinity for livestock and companion animals has allowed parthenogenetic populations of ALT to travel to and establish in overseas locations including the United States. To better understand the population dynamics of this rapidly expanding species, we sequenced the complete mitogenome of specimens collected from native and invasive ranges and performed phylogeographic analyses. As well as illustrating the diversity of Australasian and US ALT haplotypes, these methods have allowed us to estimate the source and frequency of successful introductions to the US. We highlight four potential introductions of parthenogenetic ALT, with likely origin populations identified in the Republic of Korea and Japan. These findings provide insight into potential routes of entry for ALT and other invasive tick species.

The Global Leadership Initiative on Malnutrition (GLIM) approach to malnutrition diagnosis is based on assessment of three phenotypic (weight loss, low body mass index, and reduced skeletal muscle mass) and two etiologic (reduced food intake/assimilation and disease burden/inflammation) criteria, with diagnosis confirmed by fulfillment of any combination of at least one phenotypic and at least one etiologic criterion. The original GLIM description provided limited guidance regarding assessment of inflammation, and this has been a factor impeding further implementation of the GLIM criteria. We now seek to provide practical guidance for assessment of inflammation. A GLIM-constituted working group with 36 participants developed consensus-based guidance through a modified Delphi review. A multiround review and revision process served to develop seven guidance statements. The final round of review was highly favorable, with 99% overall "agree" or "strongly agree" responses. The presence of acute or chronic disease, infection, or injury that is usually associated with inflammatory activity may be used to fulfill the GLIM disease burden/inflammation criterion, without the need for laboratory confirmation. However, we recommend that recognition of underlying medical conditions commonly associated with inflammation be supported by C-reactive protein (CRP) measurements when the contribution of inflammatory components is uncertain. Interpretation of CRP requires that consideration be given to the method, reference values, and units (milligrams per deciliter or milligram per liter) for the clinical laboratory that is being used. Confirmation of inflammation should be guided by clinical judgment based on underlying diagnosis or condition, clinical signs, or CRP.

Let G be a finite group and χ ∈ Irr ( G ) . The codegree of χ is defined as cod ( χ ) = | G : ker ( χ ) | / χ ( 1 ) and cod ( G ) = { cod ( χ ) | χ ∈ Irr ( G ) } is called the set of codegrees of G. In this paper, we show that the set of codegrees of U 4 ( 2 ) , S 4 ( q ) ( q = 2 f ≥ 4 ) , U 4 ( 3 ) , 2 F 4 ( 2 ) ′ , J 3 , G 2 ( 3 ) , A 9 , J 2 , PSL ( 4 , 3 ) , McL , S 4 ( 5 ) , G 2 ( 4 ) , HS , O ′ N and M 24 determines the group up to isomorphism.

ABSTRACT Early in the 20th century Bateson, Doncaster and Punnett formed a cooperative collective to share research findings on the chromosome theory of heredity (CTH). They cross-bred plants and animals to correlate behaviour of chromosomes and heredity of individual traits. Doncaster was the most enthusiastic proponent of the new theory and worked for years to convince Bateson and Punnett on its relevance to their own research. The two younger biologists collaborated with Bateson, the preeminent geneticist in England. As their own reputations developed, their research findings allied with the consensus on the importance of the CTH by the broader scientific community. After Doncaster’s tragic death in 1920, major objections to the theory had been resolved; Bateson and Punnett then utilized the CTH to construct chromosome maps detailing locations of specific genes on particular chromosomes in several different species. The marriage of heredity and cytology enhanced confidence that the theory was an accurate mechanism to explain inheritance in both plants and animals.

Science is the driving force behind the advancement of society making public engagement with science vital. With the rapid pace of scientific discoveries, the availability of well-balanced scientific information is possibly the most important it has ever been. This study aims to determine the effectiveness with which scientific information is disseminated to the public. This was done by conducting a survey in which people were given three articles to read about the release of genetically modified mosquitoes. These three articles were adapted from local news coverage, government authorities, and peer-reviewed scientific literature. Survey participants were queried on their relative preferences for these articles. Additionally, the top 100 hits on Google for the search item “Florida mosquito release” were analyzed to assess the availability of the scientific information preferred by survey respondents. The results of this study showed that the public seeks quality, balanced scientific literature but that these types of articles aren’t easily accessible. Articles that prioritize getting clicks are more prevalent than those that present balanced scientific research.

The Organization of Nurse Leaders of New Jersey has had a formal statewide nurse leader mentoring program since 2014 to develop leadership talent. Learn how a mentoring dyad helped them improve competencies in optimizing resource management.

Bas et al. report the clinical measurement, using High Performance Liquid Chromatography (HPLC), of asymmetric dimethyarginine in two groups of patients undergoing aortic coarctation repair.

ABSTRACT In 1956 the biomedical world was surprised to hear a report that human cells each contained forty six chromosomes, rather than the forty eight count that had been documented since the 1920s. Application of available techniques to culture human cells in vitro, halt their division at metaphase, and disperse chromosomes in an optical plane permitted perception of visual images not seen before. Researchers continued to obtain the preconceived forty eight counts until reeducation with these novel epistemic ‘chromosomes’ convinced them that they could confidently report forty six chromosomes per cell. Within only a few years, and virtually without dissent, the social community of human cytogeneticists agreed upon a shared visual culture of human chromosome count and morphology. The initial forty six count proved not to be an anomaly. A new comparison of historical and ethnomethodological studies has suggested a better understanding of how applied technologies coupled with altered human perceptions established a new science. Human cytogenetics then collaborated with medical genetics to correlate changes in the new human karyotype with disorders of clinical significance.