Hutní Projekt Frýdek-Místek (Czechia)

Abstract Here we present and discuss the record of the endangered species Isturgia roraria (Fabricius, 1776) in the Czech Silesia, originating from the Zlatohorská vrchovina (Zlatohorská Highlands) in the cadastral area of the village Dívčí Hrad (Bruntál District). The record confirms the presence of the species in Czech Silesia after more than 100 years and corresponds to its distribution in adjacent Poland. Together with the occurrence of I. roraria in the Bílé Karpaty Mts., this constitutes the only other known area of distribution in Czechia. In Silesia, the population of I. roraria is strictly associated with one of its host plants, Cytisus scoparius (L.), and with semi-ruderal habitats such as forest clearings, forest edges, clear-cuts and abandoned pastures. Current knowledge of the Lepidoptera fauna in the Zlatohorská vrchovina Highlands is very limited; therefore, detailed entomological surveys will likely reveal additional localities of the species (especially in the area defined by the settlements of Janov, Jindřichov, Krnov, Město Albrechtice and Slezské Rudoltice). The conservation status of the isolated Silesian population is unclear; however, considering its trophic and habitat associations, the Silesian population appears to be less threatened than the one in the Bílé Karpaty Mts.

We designed and validated a concise, efficient screening tool, the Sleep Apnea Risk Assessment (SARA), to identify patients at high risk of moderate to-severe obstructive sleep apnea. We conducted a two-phase, multicenter study from September 1, 2018, to October 31, 2023. We created Cohort A (n=221, mean age 50.5±13.0 years, 69.2% male) to design SARA and compared the results with the Epworth Sleepiness Scale, Berlin Questionnaire, Pittsburgh Sleep Quality Index, STOP-Bang, and STOP questionnaires. Cohort B (n=253, mean age 48.0±13.4 years, 75.5% male) served for validation. SARA comprises six variables with the highest accuracy: sleep apnea observed by the bedroom partner (8 points), snoring (5 points), male sex (3 points), age≥50 years (3 points), daytime fatigue (3 points), and body mass index≥30 kg/m2 (2 points). SARA yielded an area under the receiver operating characteristic curve (AUC) of 0.77 (95% CI: 0.71-0.83) and sensitivity of 87.2% (95% CI: 80.8-92.1) in cohort A at a cut-off score of ≥11 points. Validation in cohort B showed an AUC of 0.79 (95% CI: 0.74-0.84) and a sensitivity of 98% (95% CI: 89.2-95.4). SARA performance significantly outperformed the other questionnaires tested. The SARA is a promising new screening tool for moderate-to-severe obstructive sleep apnea, demonstrating high sensitivity and a strong ROC curve. Further large-scale validation is recommended.

In 1500 the printed version of the Bohemian Land Ordinance (Vladislavske zřizeni zemske) was issued. The royal towns hesitated to accept the new land law code for a long time, as it took away their voice at the Land Diet. The new established town league started to defend fiercely the political, judicial and economic rights and liberties of the towns. The long running conflict between the towns and the lords was ended with the St. Wenceslas Day Agreement (Svatovaclavska smlouva) in 1517. It was during this unsettled interim period that this typographical medium became the means of political communication in the Bohemian estate society and when the first attempts at its utilisation in the official practice of the government administration occurred. The contribution examines insightfully a tenth of thin prints or single sheet prints and tries to reconstruct in detail the domestic political circumstances of their publishing. Some of them have escaped the bibliographer's and historian's notice. They are well known only from unique copies. This fact shows that only at minor part of the original production has survived. The Bohemian estates representation appreciated around 1500 the typographical medium as an instrument of political power - even though only rarely - for spreading legal norms and for administrative purposes. Also the burghers succesfully utilised the typography for the propagation of their political statements. However, this happened at the end of the estates conflict - even though the printing houses were in the hands of the burghers and censorship regulation was at first limited. The struggle between the burgher estate and the nobles at the beginning of the 16th century is considered to be the major catalyst for the applying of this modern technology.

Context: Acidemia is a marker of prognosis in methanol poisoning, as well as compounding formate-induced cytotoxicity. Prompt correction of acidemia is a key treatment of methanol toxicity and methods to optimize this are poorly defined.Objective: We studied the efficiency of acidemia correction by intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) in a mass outbreak of methanol poisoning.Methods: The study was designed as observational cohort study. The mean time for an increase of 1 mmol/L HCO3–, 0.01 unit arterial blood pH, and the total time for correction of HCO3– were determined in IHD- and CRRT-treated patients.Results: Data were obtained from 18 patients treated with IHD and 13 patients treated with CRRT. At baseline, CRRT group was more acidemic than IHD group (mean arterial pH 6.79 ± 0.10 versus 7.05 ± 0.10; p = 0.001). No association was found between the rate of acidemia correction and age, weight, serum methanol, lactate, formate, and glucose on admission. The time to HCO3– correction correlated with arterial blood pH (r= −0.511; p = 0.003) and creatinine (r = 0.415; p = 0.020). There was association between the time to HCO3– correction and dialysate/effluent and blood flow rates (r= −0.738; p < 0.001 and r= −0.602; p < 0.001, correspondingly).The mean time for HCO3– to increase by 1 mmol/L was 12 ± 2 min for IHD versus 34 ± 8 min for CRRT (p < 0.001), and the mean time for arterial blood pH to increase 0.01 was 7 ± 1 mins for IHD versus 11 ± 4 min for CRRT (p = 0.024). The mean increase in HCO3– was 5.67 ± 0.90 mmol/L/h for IHD versus 2.17 ± 0.74 mmol/L/h for CRRT (p < 0.001).Conclusions: Our study supports the superiority of IHD over CRRT in terms of the rate of acidemia correction.

AimsThe randomized clinical trial RELAX‐AHF demonstrated a positive effect of vasodilator therapy with serelaxin in the treatment of AHF patients. The aim of our study was to compare clinical characteristics and outcomes of patients from the AHEAD registry who met criteria of the RELAX‐AHF trial (relax‐comparable group) with the same characteristics and outcomes of patients from the AHEAD registry who did not meet those criteria (relax‐non‐comparable group), and finally with characteristics and outcomes of patients from the RELAX‐AHF trial.Methods and resultsA total of 5856 patients from the AHEAD registry (Czech registry of AHF) were divided into two groups according to RELAX‐AHF criteria: relax‐comparable (n = 1361) and relax‐non‐comparable (n = 4495). As compared with the relax‐non‐comparable group, patients in the relax‐comparable group were older, had higher levels of systolic and diastolic blood pressure, lower creatinine clearance, and a higher number of comorbidities. Relax‐comparable patients also had significantly lower short‐term as well as long‐term mortality rates in comparison to relax‐non‐comparable patients, but a significantly higher mortality rate in comparison to the placebo group of patients from the RELAX‐AHF trial. Using AHEAD score, we have identified higher‐risk patients from relax‐comparable group who might potentially benefit from new therapeutic approaches in the future.ConclusionsOnly about one in five of all evaluated patients met criteria for the potential treatment with the new vasodilator serelaxin. AHF patients from the real clinical practice had a higher mortality when compared with patients from the randomized clinical trial.

Acta Carpathica Occidentalis, peer-reviewed scientific journal - results of original natural science research in natural sciences, especially from the Carpathian region of the Czech and Slovak Republics.

Necrotizing sialometaplasia is a benign, spontaneously healing inflammatory condition. It usually affects the hard palate, and it can mimic a malignancy both clinically and histologically. We report a new case of this rare disorder.