Hyogo Institute for Traumatic Stress

La place du consentement dans la définition pénale des infractions sexuelles occupe une position centrale dans la réflexion répressive contemporaine. Longtemps appréhendée indirectement à travers quatre notions (violence, contrainte, menace ou surprise), cette dernière n’était pas pleinement consacrée par le droit français. Sous l’effet des pressions sociales et européennes, la loi adoptée le 6 novembre 2025 place désormais le consentement au cœur du dispositif pénal. Cette réforme marque un tournant, tout en révélant la complexité d’une notion dont l’appréhension juridique se heurte à l’ambiguïté des relations humaines et aux rapports de domination qui les traversent.

Collection of data and scripts related to the paper: Jonas Gossen et al. "A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics" https://www.biorxiv.org/content/10.1101/2020.12.14.422634v2 doi: https://doi.org/10.1101/2020.12.14.422634 ACS Pharmacology and Translational Science 2021 DOI: 10.1021/acsptsci.0c00215 <strong>1. TRAPP simulation results for Sars-CoV2 3C-like main protease:</strong> include simulation of the binding pocket druggability, physical-chemical properties, and the binding site composition Protease_clean.ipynb - Jupyter Notebook containing analysis of the generated data allTables.zip - results of TRAPP simulations of the binding site flexibility using LRIP and tConcoord methods Every10-ligand_6LU7_R3.5.zip - results of TRAPP pocket analysis on the MD frames PDB-Giulia.zip - TRAPP pocket analysis of 40 PDB complexes of main protease TRAPP_properties_PDB.xlsx - binding pocket properties for 40 PDB complexes of main protease summarized in a table DrugPDB_3structures.xlsx - binding pocket properties for 3 PDB structures <strong>2. Docking &amp; Screening Results</strong> TRAPP_secondSelection_VS.csv - docking/screening of selected structures from TRAPP analysis Fred_VS.csv - docking of PDB structures using Fred Glide_VS.csv - docking of PDB structures using Glide TableS1.xlsx - Available structures of SARS-CoV-2 Mpro selected for binding site analyses. TableS2A.xlsx - SiteScore analysis of all the deposited X-ray crystal structures for the Mpro. TableS2B.xlsx - SiteScore analysis of the MSM ensemble (4-macrostates).

ABSTRACT Background Trauma-focused cognitive behavioural therapy (TF-CBT) is an efficacious treatment model for children and adolescents with trauma-related disorders. However, few studies have been conducted in community settings, and there have been no randomized controlled trials in Asian countries. Objective To evaluate the effectiveness of TF-CBT in regular community settings in Japan through comparison with a waitlist with minimal services control condition. Method Thirty Japanese children and adolescents with posttraumatic stress disorder symptoms (22 females, eight males, mean age = 13.90, range = 6–18) were randomly assigned to 12 sessions of TF-CBT or the waitlist control condition. The primary outcome measure was the Kiddie Schedule for Affective Disorders and Schizophrenia score assessed by blinded evaluators one month later. Results The mean number of sessions was 12 (range: 11–13) in the TF-CBT group and 4.87 (range: 3–7) in the control group. Intention to treat analysis showed that the TF-CBT group achieved significantly greater symptom reduction than did the control group. The effect size (Cohen’s d) between the TF-CBT and control groups was 0.96 (p =.014) for posttraumatic symptoms and 1.15 (p =.004) for depressive symptoms. However, the TF-CBT group did not show better results than the control group with regard to improvements in anxiety symptoms, psychosocial functioning, and behavioural problems. Conclusions The findings provided preliminary evidence of the effectiveness of TF-CBT for treating youth with trauma in community mental health facilities. TF-CBT in the Japanese context proved identical to the original, demonstrating that it is also suitable for use with children and adolescents in non-Western settings.

Abstract SummaryIn phylogenetic analysis, it is common to infer unrooted trees. Thus, it is unknown which node is the most recent common ancestor of all the taxa in the phylogeny. However, knowing the root location is desirable for downstream analyses and interpretation. There exist several methods to recover a root, such as midpoint rooting or rooting the tree at an outgroup. Non-reversible Markov models can also be used to compute the likelihood of a potential root position. We present a software calledRootDiggerwhich uses a non-reversible Markov model to compute the most likely root location on a given tree and to infer a confidence value for each possible root placement.Availability and implementationRootDiggeris available under the MIT licence athttps://github.com/computations/root_digger

We explored the factors promoting long-term mental health among adolescent survivors of the 2008 Wenchuan earthquake in China. We examined the associations of their long-term mental health with disaster-related storytelling and school-based psychoeducation, and of school-based psychoeducation with disaster-related storytelling. A secondary school-based cross-sectional survey was conducted 6 years after the disaster. Participants with traumatic experiences such as injury, loss, witnessing someone's death/injury and home destruction (N = 1028, mean age 15, standard deviation 1.38, male 51%) were eligible. Mental health/disaster education (MHE/DE) was defined as taking one or more lessons in MHE and/or DE at school since the earthquake. Experiences of storytelling about the disaster involved expressing distressing memories and feelings regarding the earthquake since the disaster happened, according to four groups: never expressed distressing memories and feelings, expressed them through writing/drawing, expressed them through talking to lay supporters and expressed them through talking to health professionals. Analysis of covariance was used to compare mean scores on five selected subscales of the Symptom Checklist-90 (SCL-90), the Athens Insomnia Scale (AIS) and the Psychotic-Like Experiences (PLEs) scale among the four storytelling groups. Linear regression analysis was used to identify the relationships between MHE/DE and current mental health as measured by the SCL-90, AIS and PLEs. The relationship between education and storytelling was probed by χ2 test. The talked-to-lay-supporters group showed better mental health on the SCL-90 (p ⩽ 0.001), AIS (p < 0.001) and PLEs (p = 0.004), while the consulted-health-professionals group showed worse mental health on the three dimensions of the SCL-90: depression (p = 0.05), anxiety (p = 0.02) and fear (p = 0.04), and on PLEs (p = 0.02) compared with the never-expressed group. MHE and DE were inversely associated with SCL-90, AIS and PLE scores. Participants who received these forms of education talked about their disaster experiences to lay supporters more than those who did not. MHE and DE at school may promote adolescents' mental health after a disaster. Experience of storytelling about the disaster to lay supporters may be helpful for long-term psychological recovery, and may be a potential mediating factor for school-based education and better mental health. Because of the cross-sectional nature of this study, causality cannot be inferred; therefore, further prospective intervention studies are needed to elucidate the effect of these factors on adolescent survivors' mental health.

supporting data and software associated with the paper "Machine learning analysis of tauRAMD trajectories to decipher molecular determinants of drug-target residence times" of Kokh DB, Kaufman T, Kister B, Wade RC., Front. Mol. Biosci., 24 May 2019 | https://doi.org/10.3389/fmolb.2019.00036

Daily healthcare is very important for our quality of life. Especially, in the aging countries like Japan, medical costs will increase in the near future. Almost all Japanese people have health examination in every year. By the health examination, Japanese people understand own health condition. If the results of health examination get worse, then we will have precise examinations to find a cause of the deterioration of the health condition. On the other hand, several health monitoring devices are available. Most of such devices are provided for assisting exercise. We have developed a MEMS-based human condition monitoring device and fuzzified neural network based condition estimation system. The monitoring device can obtain some kinds of sensor data from a subject person. The fuzzified neural network based condition estimation system can estimate the heart rate of the subject person from the obtained sensor data. In this paper, we improve the fuzzified neural network based system for obtaining appropriate estimation results.

This study aimed to examine the use of high doses of antipsychotic medications (≥600 mg/day chlorpromazine equivalent) in older Asian patients with schizophrenia and its demographic and clinical correlates. Information on hospitalized patients with schizophrenia aged ≥50 years was extracted from the database of the Research on Asian Psychotropic Prescription Patterns study (2001-2009). Data on 2203 patients in six Asian countries and territories, including China, Hong Kong, Japan, Korea, Singapore and Taiwan, were analyzed. Socio-demographic and clinical characteristics and antipsychotic prescriptions were recorded. The frequency for high-dose antipsychotic medications was 36.0% overall, with 38.4% in 2001, 33.3% in 2004 and 36.0% in 2009. Multiple logistic regression analysis of the whole sample showed that compared to patients receiving low-medium antipsychotic doses, those on high doses had a longer illness duration (odds ratio (OR): 2.0, 95% confidence interval (CI):1.2-3.3, p = 0.008), were more likely in the 50-59-year group (OR: 0.95, 95% CI: 0.94-0.97, p < 0.001), more often had current positive (OR: 1.5, 95% CI: 1.2-1.8, p < 0.001) or negative symptoms (OR: 1.3, 95% CI: 1.03-1.6, p = 0.03), and more commonly received antipsychotic polypharmacy (OR: 5.3, 95% CI: 4.1-6.7, p < 0.001). Extrapyramidal symptoms (p = 0.25) and tardive dyskinesia (p = 0.92) were not more frequent in the high-dose group. High doses of antipsychotic medications were used in more than one third of older Asian patients with schizophrenia. The reasons for the frequent use of high antipsychotic doses in older Asian patients warrant further investigation.

Since the Great Hanshin Awaji Earthquake in 1995, media reports on importance of mental health services for survivors and service providers, and hundreds of mental health teams were coordinated and dispatched to the disaster areas right after the Great East Japan Earthquake and Tsunami last year. However, how much of such services were truly welcomed and utilized by the survivors? Some argue that the concept of mental health itself is western born hence it does not really fit with Japanese culture. This paper, however, points out aftereffects of disaster are universal but how they are expressed might be influenced by culture, social structures, and individual differences. And survivors in general need support to recover but it does not have to be ‘mental health’ per se, and it is up to providers' ability in how to present it so that mental health service is accepted and utilized. Examples from author's experiences are included to make points.