Industriale Chimica (Italy)

Magnetic Nanoparticles In their Research Article (10.1002/adfm.202522732), Teresa Pellegrino and co-workers report the gram-scale synthesis of unique anisotropic iron oxide cubic nanoparticles featuring cubic morphology and multicore architecture. They exhibit low coercivity, high saturation magnetization, record magnetic heating losses, and strong MPI signals, enabling advanced theranostic oncology applications.

We present an integrated multiscale framework that combines the Density Matrix Renormalization Group (DMRG) with a polarizable fluctuating-charge (FQ) force field for the simulation of electronic excited states in solution. The method exploits the capabilities of DMRG to accurately describe systems with strong static correlation, while the FQ model provides a self-consistent and physically grounded representation of solvent polarization within a QM/MM embedding. The DMRG/FQ approach is applied to representative solvated systems, using extensive molecular dynamics sampling. The method yields reliable excitation energies, solvatochromic shifts, and a close agreement with available experimental data. The results highlight the importance of mutual polarization for capturing specific solute-solvent interactions, particularly in systems where hydrogen bonding or directional interactions play a dominant role.

The development of efficient circularly polarized electrochemiluminescence (CP-ECL) probes is still at its infancy and examples are still very limited. Yet, their achievement would enable gathering a readout that carries privileged information on the probe's chiral environment by monitoring luminescence polarization bias with high signal-to-noise ratio. Notwithstanding, this is a highly challenging task and requires judicious chemical engineering of chiral ECL-active emitters. Herein, we aim at expanding the palette of CP-ECL luminophores by presenting a novel class of enantiopure heterobinuclear Ir(III)-Au(I) complexes, which are investigated thoroughly by means of chemical, structural, and (chiro-)optical techniques. The ground and excited state properties are also elucidated by using density functional theory (DFT) approaches including spin-orbital coupling (SOC) perturbation. The chiral-at-metal complexes display luminescence with a polarization bias of the emitted light that is function of the helical arrangement of the coordination sphere around the Ir(III) center. Overall, the photo- and electro-active complexes unraveled in this work combine unparallelly high photoluminescence quantum yield in the orange region, excellent circularly polarized luminescence (CPL) brightness up to 4.5M-1 cm-1 with a notable ECL activity. Finally, these features provide emitters with CP-ECL efficiency that encompass remarkably by a factor 3.5 that of the well-known benchmark tris-(2,2'-bipyridyl)ruthenium(II).

Abstract A convenient route to the Nakamura‐Yamago methylenecyclopropane (MCP) precursor 1 to oxygen‐stabilized, singlet trimethylenemethane (TMM) is reported, which avoids the hurdles of the original preparation procedure. An effective oxidation protocol is also introduced for converting the sensitive ketene acetals (KAs) from 1,3‐dipolar cycloaddition of 1 to electron‐poor olefins, into the corresponding α‐hydroxyesters. The method, based on the use of dimethyldioxirane (DMDO) in acetone, affords fair to good yields (23–81%) for a number of KAs endowed with ketone, ester, or imide functional groups, as well as additional C─C double bonds. The utility of the protocol is further exemplified by the diastereoselective preparation of the Rokach‐Galano‐Durand bicyclic lactone rac‐18, one of the most versatile building‐blocks for the synthesis of isoprostanoidic derivatives.

Biodegradable polymer matrices, PCL and PBSA were used to fabricate magnetic composites with recycled NdFeB and rare earth-free lab-synthesized ferrite fillers (SrFe12O19 and SrFe12O19–CoFe2O4) across a wide filling range (1–90%).