Institut Clinident

Sensitive skin syndrome (SSS) affects individuals from all ethnic groups. However, studies across different populations remain limited, despite recognised differences between populations. Thus, we examined SSS in Thai and Polish subjects, assessing the tolerance and efficacy of a dermo-cosmetic product in both populations. Thai participants were involved in a 28-day open-label study, while Polish subjects took part in a 56-day double-blind, randomised study comparing the product with a control cream. Clinical and functional signs were evaluated, alongside quality of life (QoL) using the Burden of Sensitive Skin (BoSS) questionnaire. The product was well tolerated in both groups over time, leading to significant improvements in all clinical and functional signs (p < 0.05 to p < 0.001) and enhancing QoL (p < 0.005 in Thailand; p < 0.001 in Poland). At baseline, Polish subjects exhibited greater redness and higher BoSS scores to questions relating to visual signs (p < 0.001). Conversely, Thai participants reported more pronounced tingling, pain and itching, along with higher BoSS scores relating to sensory symptoms (p < 0.001). The study highlights differences existing in the perception of SSS symptoms between a Thai and Polish population and demonstrates that the dermo-cosmetic cream effectively alleviates SSS symptoms and improves QoL in both ethnic groups.

L’article de Sophie Doudet explore la manière dont la Grèce imprègne l’œuvre romanesque de Malraux, et ce, malgré ses nombreuses références aux arts asiatiques. Cette imprégnation va de la fascination précoce de l’écrivain pour le kouros à sa réflexion sur l’art comme anti-destin dans Les Noyers de l’Altenburg.

The impact of intracoronary imaging on outcomes, after provisional versus dual-stenting for bifurcation left main (LM) lesions, is unknown. We investigated the effect of intracoronary imaging in the EBC MAIN trial (European Bifurcation Club LM Coronary Stent study). Four hundred and sixty-sevenpatients were randomized to dual-stenting or a stepwise provisional strategy. Four hundred and fifty-fivepatients were included. Intravascular ultrasound (IVUS) or optical coherence tomography (OCT) was undertaken at the operator's discretion. The primary endpoint was death, myocardial infarction or target vessel revascularization at 1-year. Intracoronary imaging was undertaken in 179 patients (39%; IVUS = 151, OCT = 28). As a result of IVUS findings, operators reintervened in 42 procedures. The primary outcome did not differ with intracoronary imaging versus angiographic-guidance (17% vs. 16%; odds ratio [OR]: 0.92 (95% confidence interval [CI]: 0.51-1.63) p = 0.767), nor for reintervention based on IVUS versus none (14% vs. 16%; OR: 0.88 [95% CI: 0.32-2.43] p = 0.803), adjusted for syntax score, lesion calcification and ischemic symptoms. With angiographic-guidance, primary outcome events were more frequent with dual versus provisional stenting (21% vs. 10%; adjusted OR: 2.11 [95% CI: 1.04-4.30] p = 0.039). With intracoronary imaging, there were numerically fewer primary outcome events with dual versus provisional stenting (13% vs. 21%; adjusted OR: 0.56 [95% CI: 0.22-1.46] p = 0.220). In EBC MAIN, the primary outcome did not differ with intracoronary imaging versus none. However, in patients with angiographic-guidance, outcomes were worse with a dual-stent than provisional strategy When intracoronary imaging was used, there was a trend toward better outcomes with the dual-stent than provisional strategy.

Pour la première fois depuis la Révolution française des étrangers établis en France se portent spontanément et massivement volontaires pour la défense du droit et de la liberté. Ce, avant même la déclaration de la guerre. Hérauts de cette croisade, les représentants de l’élite intellectuelle et artistique européenne et américaine établie dans la capitale sont suivis par la foule des étrangers de condition modeste qui veulent montrer leur reconnaissance au pays qui les a accueillis. Incorporés dans des régiments de marche de la Légion étrangère créés pour la circonstance, par leur conduite au feu, ces engagés volontaires pour la durée de la guerre de 1914 contribuent ainsi à légitimer et à pérenniser cette composante de l’armée d’Afrique.