Institute For Leadership And Communication Studies

In this chapter, we expose an autistic space conjecture addressing a knowledge space of autism and its evaluation. The Real-Object-Approach of Language (ROAL)-hypothesis relies on an epistemic-mathematical model of autism adopting a framing/antiframing approach to linguistic/non-linguistic individuation of text/field varying from the pathological account on autism. The focus of the first phase is on the spectral plane of knowledge particles (linguistic/non-linguistic) by means of a parametric formula implying an autistic inversion of exponentiation of acts/facts and perception/production (representation) on the invariants of Action Cognition Emotion (CEA) taken as the individuals of consciousness and their exponents of Source-effectuator-target: it pinpoints spectral variation on perceptual spheres (intero/proprio/extero) whereby the framing/antiframing model yields a diathetic split proper to autism. The empirical/experimental verifiability of CEA individuals in autism relies particularly on random constructions and their differential search patterns. Within a monistic world, text/field configuration invariants indicate a mental space inwardly inverted on an Einsteinian/Galilean world. Thus, the first phase of the present work entails an applicability in which brain interconnectivity is considered, in particular hippocampal-cortical interactions. In sum, we proved a feasible method of knowledge particles on the autistic plane and its metrics of linguistic/non-linguistic individuals between individuation/configuration and individuality.

L’activite antifongique in vitro de deux huiles essentielles (HE) de plantes aromatiques et medicinales (PAM) (thym et menthe pouliot) et de l’acide oleique a ete evaluee contre 15 souches de differentes especes de dermatophytes isolees de diverses dermatophyties traitees a l’Hopital d’enfants de Rabat dont Trichophyton rubrum (5 isolats), Trichophyton mentagrophytes (4 isolats) et Microsporum canis (4 isolats) (Microsporum gypseum et Epidermophyton floccosum sont issues de notre collection mycologique) et 7 levures dont 4 de Candida albicans et 3 de Malassezia sp. Cette activite a ete comparee a celle de la griseofulvine, le ketoconazole, l’isoconazole nitrate et le sulfate de polymyxine B. Les CMI obtenues avec les HE sur les agents responsables de mycoses sont similaires a celles qui sont obtenus avec les imidazoles. L’acide oleique exerce une action fongistatique sur les dermatophytes sensibles tels T. rubrum, E. floccosum a des concentrations allant de 150–200 μg/ml. Cependant, les dermatophytes telluriques et zoophiles sont resistants. Les levures ne sont pas inhibees par l’acide oleique. La polymyxine B exerce une action fongitoxique importante sur Malassezia sp. et plusieurs dermatophytes. Pour le C. albicans, la sensibilite est variable.

The aim of the study is to look retrospectively for gene alterations and evaluate apoptosis in rhabdomyosarcomas (RMSs) from 40 children including 24 patients not previously treated. Histological subtype was botryoid in 1 case, spindle cell in 2 cases, embryonal in 22 cases, alveolar in 10 cases, and undetermined in 5 cases. Gene expression was evaluated immunohistochemically for p53 tumor suppressor gene, MDM2 oncogene, and bcl-2 gene. N-myc amplification was detected by in situ hybridization. Apoptotic cells and bodies were recognized morphologically and stained by 3'-OH end labeling. Intranuclear accumulation of p53 protein was obvious (>25% of tumor cells) in two recurrent embryonal RMSs. Expression of the MDM2 gene was intense (80% of tumor cells) in a recurrent and metastatic embryonal RMS. Amplification of the N-myc gene was obvious (about 20% of tumor cells) in an alveolar RMS metastatic at diagnosis. Expression of the bcl-2 gene was intermediate (25–75% of tumor cells) in 26% of cases and high (>75% of tumor cells) in 10% of cases either embryonal or alveolar. The percentage of tumor cells showing morphologically recognizable apoptosis was 0.2–7.5% (mean 2.9%). There was no correlation between apoptosis and histological subtype, bcl-2 expression, or previous treatment.