Institute for Progressive Medicine

Stealth adaptation is a virus immune evasion/escape mechanism that comprises the deletion or mutation of the viral genes, which code for components targeted by cellular immunity. It can also require the incorporation of additional genetic sequences to regain the capacity for replication and transmission. Stealth adapted viruses typically cause non-inflammatory infections, which are particularly symptomatic when they involve the brain. Stealth adaptation has occurred with cytomegalovirus contaminants of polio vaccines produced in kidney cell cultures of rhesus and African green monkeys. Two aspects of the current Covid-19 vaccines are inducive to the formation of stealth adapted SARS-CoV-2 coronaviruses. These are the relative ineffectiveness of intramuscular injections in stimulating fully effective respiratory mucosal immunity and the inclusion of only a single virus component as the immunogen, namely the spike protein. Stealth adapted coronaviruses will have the potential to cause chronic, non-inflammatory brain illnesses similar to those being caused by stealth adapted monkey cytomegaloviruses. These include the chronic fatigue syndrome (CFS) and autism. The long Covid syndrome has many features in common with CFS and the affected patients need to be evaluated for stealth adapted virus infections. With regards to potential therapy, the body has a non-immunological anti-virus defense mechanism that is mediated by the alternative cellular energy (ACE) pathway. Enhancing the ACE pathway, especially in those susceptible to severe Covid-19 illness and in those who are experiencing the long Covid syndrome, is preferable to having to repeatedly vaccinate mankind against evolving variants of the SARS-CoV-2 virus. Furthermore, immunization is not indicated in those who are already infected stealth adapted virus infected. Optimizing ACE pathway-based therapies will also have benefits in treating other stealth adapted virus brain diseases including CFS and autism.

Stealth adaptation is a generic immune evasion mechanism, which can potentially occur with all viruses [1-4]. It involves the deletion or mutation of the genes coding for the relatively few virus components typically targeted by the cellular immune system. A further characteristic of certain stealth adapted viruses is the incorporation of additional genetic sequences of cellular and bacterial origins [5-8]. These “renegade” genetic sequences can be subsequently transmitted between humans as components of infectious stealth adapted viruses. The best characterized stealth adapted virus, referred to in GenBank as stealth virus 1, is a derivative of an African green monkey simian cytomegalovirus (SCMV) [2,4,9]. It was repeatedly cultured from a patient with the chronic fatigue syndrome (CFS) [10]. A similar virus (stealth virus-2) was isolated from the cerebrospinal fluid of a comatose patient with a 4-year history of a bipolar psychosis [11]. Stealth virus-1 was cloned and the complete or partial DNA sequences of 248 clones were submitted to GenBank. Of these clones, 200 of the sequences correspond to regions of the SCMV genome. The sequences are unevenly distributed over the genome of the originating SCMV, with clear evidence of major deletions and genetic instability. Fourteen clones contained genetic sequences that were derived from non-coding regions of the human genome. These incorporated cellular sequences have also undergone genetic changes indicative of the genetically unstable stealth adapted virus genome [12].

It has generally been assumed that humans and animals can only obtain energy from food; with the mitochondria being the principal cellular component for food metabolism. Basic calculations of the daily work output of humans indicate an energy expenditure far in excess of the approximately two thousand Calories consumed each day in a typical diet. Humans must, therefore, have an alternative cellular energy (ACE) pathway that is empowered by an environmental force. Indeed, based on experimental observations, some of which are detailed herein, this force has been designated as KELEA; an abbreviation for Kinetic Energy Limiting Electrostatic Attraction. KELEA is seemingly reversibly bound to both positive and negative electrical charges. It likely provides the repulsive mechanism that prevents the ultimate fusion of electrostatic attracted opposing electrical charges. It is further proposed that KELEA is drawn to the isolated electrical charges on dipolar molecules, including water. Increasing the level of KELEA in water weakens the attachments between the electrostatically bonded water molecules. Consequently, the water molecules become kinetically more active; as can be shown in specific assays. The term “excellerated water” is being used rather than “activated water” to more specifically define water with a significantly heightened level of a non-thermal kinetic activity. The added kinetic energy present in KELEA excellerated water can be transferred from the water molecules to other types of molecules. The energy is also transferable between the molecules involved in linked chemical reactions. As such, it can be equated with chemical energy. It is likely that the fluctuating electrical activity of the normally functioning brain acts as the major receiver of KELEA from the environment. This is consistent with one of the consequences of brain damage being an overall insufficiency of energy for the ACE pathway. Individual neurons probably derive some of the energy for their own cellular needs from the repetitive depolarization of the cell. This may explain why hyperexcitability of neurons can occur in response to cell damage. Such an adaptive mechanism is unlikely to be sustainable, however, especially because of the continuing need to synthesize neurotransmitters and membrane ion channels.

This article extends the concept of stealth adaptation of viruses beyond the avoidance of cell mediated immune recognition due to deletion or mutation of the genes coding for the relatively few virus components normally targeted by the cellular immune system.A fragmented virus genome can incorporate additional cellular and bacterial genetic sequences, while continuing to delete the originating virus sequences.Virus replication and transmission extends to the incorporated and substituted sequences, which have seemingly abandoned their normal locations to essentially become viral.By analogy with deserting or with the switching of allegiance, the term renegade sequences is suggested to describe the incorporated sequences beyond those remaining from the initiating virus.The over expression of certain genetic sequences has been linked to the occurrence of particular types of illnesses, including the development of various cancers.Although yet to be clinically acknowledged, this is an inherent risk of transmissible, genetically altered cellular sequences.Humans have become infected with monkey-derived stealth adapted viruses.The monkey-derived cellular sequences in these viruses can potentially undergo homologous recombination with human germline DNA leading to multigenerational illnesses.These and other major implications of the existence in humans of reformed viruses being disguised as self, and/or as bacteria are discussed in this article.

A natural force has been proposed, which is required to prevent the fusion and disappearance of the discrete electrical charges that are present on electrostatically attached opposing electrical charges. This force may also explain the repulsion between objects with either matching positive or negative electrical charges. The energy of this force is referred to as KELEA (kinetic energy limiting electrostatic attraction). KELEA is especially attracted to dipolar compounds and to other materials with spatially separated opposite electrical charges. These compounds can be used to increase the level of KELEA in water. KELEA activated water can become an added source of KELEA for objects that are placed in close proximity to the water. It is generally held that the weight of an object is solely determined by its mass in relation to that of the earth. Yet, it was previously reported that the measured weight of certain KELEA attracting objects can undergo considerable variability over time. This observation is consistent with the concept that KELEA can contribute to the measured weight of certain objects. The present study strengthens this concept by demonstrating that the weight of cellulose containing materials, including paper, cotton fabrics, and wood, is increased if the materials are placed close to containers of KELEA activated water. It is further shown that electromagnetic radiation can significantly reduce the added weight of the KELEA exposed cellulose containing materials. Moreover, the previously added weight of the materials can be regained by replacing the materials back into the KELEA enhanced environment. It is proposed that the electrical charges that accompany electromagnetic radiation are able to competitively withdraw some of the KELEA from certain KELEA-enhanced objects. This effect can be reliably demonstrated using single sheets of writing paper, which are primarily composed of mechanically-bonded, branched cellulose fibers. There can be considerable fluctuations of the weight of the materials exposed to electromagnetic radiation after having been placed nearby to KELEA activated water. The weight instability is interpreted as being due to the electromagnetic radiation also triggering a dynamic process of rapid additions and removals of significant quantities of KELEA to and from objects. These observations are relevant to the further understanding of KELEA and to the potential health and climate consequences of manmade electromagnetic radiation causing a reduction in the environmental levels of KELEA.

Stealth adapted viruses differ from the viruses from which they are derived in not being effectively recognized by the cellular immune system.This is because of the deletion or mutation of the genes coding for the relatively few virus components, which are generally targeted by cytotoxic T lymphocytes.Stealth adapted viruses do not, therefore, normally evoke inflammation, the hallmark of most infectious illnesses.A stealth adapted virus was repeatedly cultured from the blood of a patient with the chronic fatigue syndrome (CFS).Polymerase chain reaction (PCR) performed on the culture identified the virus as being derived from an African green monkey simian cytomegalovirus (SCMV).The PCR also amplified a genetic sequence closely related to a normal cellular gene.Further analysis of the viral DNA indicated that it was fragmented and genetically unstable.Moreover, additional genetic sequences have been incorporated into the replicating virus genome.Several of the additional sequences are originally of cellular origin with subsequent genetic modifications.Other incorporated sequences are of bacteria origin.PCR performed on cultures from some other CFS patients, led only to the amplification of modified cellular sequences, including a sequence clearly derived from the rhesus monkey genome.It is proposed that as part of the stealth adaptation process, sequences of the original infecting virus can be largely displaced by cellular and/or bacterial sequences, which have essentially switched their affiliation to that of the stealth adapted virus.For this reason, they are referred to as renegade sequences.The term "renegade viruses." is also proposed to describe those viruses in which the originating conventional virus sequences have yet to be detected.The findings are relevant to efforts to seek a virus cause of many common illnesses, including CFS, and to the possible misattribution of certain illnesses to bacterial infections.

The scope of human and animal virology research is likely to undergo a major expansion. It will occur with the realization that the immune system may fail to effectively recognize derivative viruses, which no longer express the major antigens normally targeted by cytotoxic T lymphocytes (CTL). This immune evasion mechanism has been termed stealth adaptation. Persistent infections with stealth adapted viruses can lead to various illnesses and especially those with neuropsychiatric symptoms. Certain stealth adapted viruses almost certainly entered into humans via monkey cytomegalovirus contaminated polio vaccines. Preexisting stealth adapted virus infections may render individuals susceptible to disease provocation from administered vaccines. On a more promising note, the research has helped identify an alternative cellular energy (ACE) pathway that can suppress both stealth adapted and conventional viruses. The ACE pathway is providing a new therapeutic paradigm that extends beyond virology to general medicine. It is also leading towards a basic understanding of how Nature prevents the fusion of opposite electrical charges. It is postulated that Nature does so through a fundamental force, tentatively termed KELEA (kinetic energy limiting electrostatic attraction).