Institute of Indigenous Peoples' Health

We conducted the first light curve study of the binary star EL Tuc within the Binary Systems of South and North project’s framework. The photometric observations were made using standard multiband BVR c I c filters at an observatory in Argentina. We presented a new ephemeris for EL Tuc and a linear fit to the O – C diagram, utilizing our extracted times of minima and additional literature. We employed the PHysics Of Eclipsing BinariEs Python code and the Markov chain Monte Carlo approach for the system’s light curve analysis. The target system’s light curve solution required a cold starspot on the hotter component. We conclude that EL Tuc is a total contact binary system with a low mass ratio of q = 0.172 ± 0.002, an orbital inclination of i = 83.°74 ± 0.°40, and a fillout factor of f = 53.7% ± 1.6%. We used the P–a relationship and the Gaia Data Release 3 parallax method to determine the absolute parameters of EL Tuc to compare the precision of our results. This system was classified as W-type based on the mass and effective temperature of the companion stars. The positions of the systems were depicted on the M–L, M–R, T–M, and q–L ratio diagrams. The relationship between the spectroscopic and photometric mass ratios of binaries was discussed.

Abstract INTRODUCTION: Different berberine preparations were evaluated for their effectiveness on lowering blood glucose in a pilot, open-label, crossover study conducted in healthy adults. METHODS: Fourteen healthy volunteers of both sexes were recruited, and seven completed all treatments in the study. Study participants ingested one of three berberine preparations containing 500mg of berberine, respectively. A one week wash out period was included between treatments. A control group was included to measure the participants’ baseline response to a 75g glucose solution without any treatment, and the following interventions were administered: berberine powder in hard gelatin capsules, berberine in an oil matrix encapsulated in soft-gelatin capsules, and berberine in LipoMicel® matrix encapsulated in soft-gelatin capsules. Blood glucose concentrations in each participant were monitored from pre-dose baseline, before the capsules were ingested, until up to 3 hours after the capsules were ingested. RESULTS: LipoMicel Berberine treatment led to reduced blood glucose concentrations Area Under Curve (AUC, mean difference: 1.57; 95% CI: 0.021 - 3.12; P = 0.046; Cohen’s d = 1.53) and reduced maximum glucose concentration (Gmax, mean difference: 1.07; 95% CI 0.004 - 2.14; P = 0.049; Cohen’s d = 1.52) compared to the control group when no-treatment was given. No adverse events related to berberine treatments were reported by participants throughout the study period. CONCLUSIONS: LipoMicel Berberine was effective in lowering blood glucose AUC by 12% after two 500mg doses in 7 participants. Berberine in other formulations may require a longer dosing regimen before blood glucose lowering effects can be demonstrated.

Berberine is a plant-origin quaternary isoquinoline alkaloid with a vast array of biological activities, including antioxidant and blood-glucose- and blood-lipid-lowering effects. However, its therapeutic potential is largely limited by its poor oral bioavailability. The aim of this study was to investigate the in vitro solubility and Caco-2 cell permeability followed by pharmacokinetic profiling in healthy volunteers of a new food-grade berberine delivery system (i.e., Berberine LipoMicel®). X-ray diffractometry (XRD), in vitro solubility, and Caco-2 cell permeability indicated higher bioavailability of LipoMicel Berberine (LMB) compared to the standard formulation. Increased aqueous solubility (up to 1.4-fold), as well as improved Caco-2 cell permeability of LMB (7.18 × 10−5 ± 7.89 × 10−6 cm/s), were observed when compared to standard/unformulated berberine (4.93 × 10−6 ± 4.28 × 10−7 cm/s). Demonstrating better uptake, LMB achieved significant increases in AUC0–24 and Cmax compared to the standard formulation (AUC: 78.2 ± 14.4 ng h/mL vs. 13.4 ± 1.97 ng h/mL, respectively; p < 0.05; Cmax: 15.8 ± 2.6 ng/mL vs. 1.67 ± 0.41 ng/mL) in a pilot study of healthy volunteers (n = 10). No adverse reactions were reported during the study period. In conclusion, LMB presents a highly bioavailable formula with superior absorption (up to six-fold) compared to standard berberine formulation and may, therefore, have the potential to improve the therapeutic efficacy of berberine. The study has been registered on ClinicalTrials.gov with Identifier NCT05370261.

Abstract Uamashtakan. Tekuatepeliu. Manishtikaushipu. Uashaupishkau. Manikuakanishtiku. I am a river of names. Like countless waterways around the world, I have been given a single official denomination—Manicouagan—by the State through the colonial renaming of land. Though the word Manicouagan derives from the original language of my People, the Pessamiulnuat (Innus of Pessamit), it carries a very small piece of my whole history and speaks with a monolithic voice. As an ancestral route connecting families to their hunting territories, each of my swirls and back eddies has something to say, witnesses to a longstanding and ongoing narrative. Going back to the meanings, practices, stories, and values that some of my People's denominations still bear, I wish to make myself heard differently from the voices that are both theirs and mine.

Driven by the proliferation of rich media services and a drastic increase of data availability, the demand for high-speed data transfer in the data center continues to grow at greater than 26 percent year-over-year [1]. This urges the imminent solution of top-of-rack switches in hyperscale networks with faster I/O interfaces to simultaneously support both low power and high throughput. Supporting the substantial bandwidth increase has driven the development of new electrical and optical interconnect standards which enable 100Gb/s per channel including IEEE 802.3ck and CEI-112G with PAM-4 modulation in conjunction with forward error correction (FEC) [2]. For long-reach applications, a transceiver architecture with >40dB channel equalization is critical due to the extra 8-10dB package insertion loss. To resolve those bottlenecks, this work presents an ADC-DSP based PAM-4 transceiver capable of equalizing >41.5dB lossy channels and achieving 112Gb/s per channel and 896Gb/s overall retimer throughput in 7nm FinFET.

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In this article, Dr. Richard Vedan, a Secwepmec, lodge keeper, and medical social worker converses with Dr. Carolyn Kenny about critical elements of medical ethnomusicology as seen and experienced through an Indigenous context. Dilemmas of individualism versus collectivism and isolation versus connectivity underlie the entire conversation. Relevant themes in the traditional use of music in Indigenous healing are discussed.

Sandra P. Thomas is a professor in and the director of the PhD program in nursing at the University of Tennessee College of Nursing in Knoxville. Professional Development is coordinated by Linda Burnes-Bolton DrPH, RN, FAAN:[email protected].