Integra (United States)

Cationic dyes persist in water not because they are hard to recognize, but because most adsorbents cannot engineer the right electrostatic microenvironment without sacrificing crystallinity, porosity, or recyclability.Here we encode phenolate-rich anionic pockets into the pore walls of two -conjugated 2D covalent organic frameworks, TU-331 and TU-332, constructed by symmetry-matched Schiff-base reticulation of 2,4-dihydroxybenzene-1,3,5-tricarbaldehyde with C3-symmetric triamine linkers.The resulting honeycomb lattices exhibit permanent microporosity while presenting oxygen-rich, negatively polarized interfaces that preferentially bind aromatic cations.TU-331 delivers rapid and high-capacity uptake of basic green 1 and methylene blue (qmax = 302.70 and 279.97 mg g 1 ), far exceeding adsorption of sulfonated azo anions.Zeta-potential and pH studies reveal electrostatic amplification of binding under basic conditions, enabling efficient regeneration with ~99.5% capacity retention after five cycles.Importantly, TU-331 decolorizes authentic multicomponent textile dyeing effluents from a commercial facility, demonstrating function under viscosity-and additive-rich industrial matrices.Density functional theory (DFT) and Symmetry-adapted perturbation theory (SAPT) analyses quantify the selectivity origin: strongly favorable binding for cationic dyes (~ -140 kcal mol 1 ) dominated by Coulombic attraction and dispersion-driven stacking, versus unfavorable association for anionic dyes.These results establish reticular microenvironment design as a blueprint for charge-selective dye capture in real wastewater.

The Family Health Strategy (FHS) is the main model for reorganizing Primary Health Care (PHC) in Brazil, responsible for expanding population access to public services and strengthening the Unified Health System (SUS). This article aims to analyze the importance of the FHS in health promotion, addressing its advances, outcomes, and current challenges. The study adopted a qualitative approach based on bibliographic review and documentary analysis of scientific and institutional sources. The results show that the FHS has significantly contributed to reducing infant mortality, improving chronic disease indicators, increasing care coverage, and consolidating preventive and educational practices in health. Its core elements include multidisciplinary teamwork, territorialization, and continuous bonding with families, which ensure comprehensive and humanized care. However, obstacles such as underfunding, high professional turnover, and lack of adequate infrastructure persist. It is concluded that strengthening the Family Health Strategy is essential for the sustainability of the Unified Health System and the consolidation of the universal right to health in Brazil.

In this study, we constructed and validated deep learning models capable of predicting the osteogenic differentiation stages of mesenchymal stem cells (MSCs) using only phase-contrast microscopy images. UE7T-13, an immortalized human MSC line, was cultured in osteoinductive medium. Phase-contrast microscopy images were acquired at D0, D1, D5, D10, and D14 of differentiation. Two deep learning models, ResNet-50 and DenseNet-121, were trained to perform multi-class classification of osteogenic differentiation stages. Model performance was evaluated using precision, sensitivity, F1 score, and overall accuracy. The overall accuracy of the ResNet-50 model was 0.700 and that of the DenseNet-121 model was 0.684. The highest F1 scores occurred at D5, which may reflect more distinctive morphological features during mid-stage differentiation. Our results suggest that deep learning has the potential to non-invasively identify osteogenic differentiation stages based on morphological features alone.

This paper reports on the use of TCAD for the thermal analysis of large area discrete RF power transistors to compare thermal only vs. coupled electro-thermal simulation. The specific case investigated in this work is a 48mm GaN-on-SiC HEMT RF power transistor soldered to a 0.040 “ thick metal package flange which is soldered to a copper heatsink. Using similar material parameters and mesh structures, the device operated at <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$2 ~\mathrm{W} / \text{mm}$</tex> DC dissipated power yields 5°C peak channel temperature difference between the two methods. The discrepancy is attributed to the difference in which the uniform heat sources in the thermal only approach are non-uniform with the physicsbased electro-thermal approach. A larger temperature difference is anticipated at higher dissipated power levels.

The syntrophic obligate proton-reducing bacterium Syntrophus buswellii DSM 102354T, isolated from anaerobic digester sludge, degrades benzoate and possibly hydrocinnamate (phenyl-3-propionate) when grown with a suitable hydrogenotrophic partner. The complete genome sequence data provide insight regarding aromatic compound degradation under thermodynamically limiting conditions when exogenous electron acceptors are absent.

ABSTRACT Background Elevated blood counts in polycythemia vera (PV) are associated with increased thrombotic risk, which contributes to morbidity and mortality. Research design and methods This retrospective study describes treatment patterns and blood count control in patients with PV managed at community oncology practices (January 2014–February 2023; Integra Precision Q database). Results Of a total 10,112 patients, most received phlebotomy (68.1%) or hydroxyurea (HU; 28.2%) as initial treatment, with median follow-up of 32.1 (IQR, 13.5–58.5) months and 31.5 (IQR, 16.8–54.9) months, respectively. Changing treatment was less common than remaining on initial treatment despite 67.8% of patients on phlebotomy and 30.4% on HU having elevated hematocrit (≥45%) after 1 year of treatment. In contrast, 85.4% of patients who switched to ruxolitinib from HU achieved hematocrit < 45% after 1 year, and fewer required phlebotomy during ruxolitinib treatment than with HU treatment (RUX, 29.3%; HU, 53.5%). Additionally, 54.2% of patients who switched to ruxolitinib achieved white blood cell counts < 11 × 109/L, and 57.5% achieved platelet counts ≤ 400 × 109/L after 1 year of ruxolitinib treatment. Conclusions This real-world evidence highlights the importance of considering alternative therapies for patients whose initial treatment regimen does not provide adequate clinical benefit.

<strong class="journal-contentHeaderColor">Abstract.</strong> Anomalous freshwater fluxes from the Greenland and Antarctic ice sheets and ice shelves are impacting the surrounding oceans and we need to be able to account for these effects in climate model simulations over the historical period and beyond. In previous phases of the Coupled Model Intercomparison Project (CMIP), models mostly either assumed that the ice sheets were in mass balance, or that discharge from the ice sheets was constant, but in neither case was the observed increasing discharge properly accounted for. In this paper, we present an updateable dataset of absolute and anomalous freshwater mass fluxes from both ice sheets. These fluxes can be implemented in historical climate simulations as a forcing for models that do not (yet) include interactive ice sheets, or used to evaluate models that do. We also make recommendations for how climatological and anomalous fluxes can be implemented in climate models that may have different approaches to interactions with the ice sheets. These forcings are available for CMIP7 simulations and should lead to more robust and coherent simulation of sea surface temperature, sea ice and regional sea level trends in the recent historical period, and improve the credibility of projections.

<strong class="journal-contentHeaderColor">Abstract.</strong> Anomalous freshwater fluxes from the Greenland and Antarctic ice sheets and ice shelves are impacting the surrounding oceans and we need to be able to account for these effects in climate model simulations over the historical period and beyond. In previous phases of the Coupled Model Intercomparison Project (CMIP), models mostly either assumed that the ice sheets were in mass balance, or that discharge from the ice sheets was constant, but in neither case was the observed increasing discharge properly accounted for. In this paper, we present an updateable dataset of absolute and anomalous freshwater mass fluxes from both ice sheets. These fluxes can be implemented in historical climate simulations as a forcing for models that do not (yet) include interactive ice sheets, or used to evaluate models that do. We also make recommendations for how climatological and anomalous fluxes can be implemented in climate models that may have different approaches to interactions with the ice sheets. These forcings are available for CMIP7 simulations and should lead to more robust and coherent simulation of sea surface temperature, sea ice and regional sea level trends in the recent historical period, and improve the credibility of projections.

En Uruguay el problema de la vivienda es un tema de larga data. Con el incremento de la población hasta mediado el s. XX y los cambios en el uso del suelo originados por las transformaciones sociodemográficas, el acceso a la vivienda es uno de los principales problemas en el país. Este artículo aborda el proceso de reconfiguración urbana y social en Villa Farré, al noreste de Montevideo. En el transcurso de las últimas décadas ese territorio pasó de ser un espacio categorizado como suelo rural, donde había chacras rurales productivas, a ser una zona urbana, intervenida por diversos programas de la política pública de vivienda para los sectores de población con menores ingresos. En el contexto de un Programa de Actuación Urbanística más amplio, Villa Farré es escenario de un proceso donde personas provenientes de distintos lugares y contextos pasan a compartir un territorio. A través de la recopilación de las percepciones de las personas realojadas y vecinos originales, se busca poner en cuestión qué tipo de vivienda y hábitat se logra para quienes van a vivir en esos territorios reconfigurados, en especial para quienes fueron realojados en esa zona y deben afrontar su vida con entramados relacionales nuevos.