International Society for Computational Biology

Pumas (Puma concolor) occupy a vast geographical range spanning from Canada to Argentina. Due to urbanization and unregulated hunting, pumas in Florida, known as panthers, are the only breeding population east of the Mississippi River. In the 1990s, Florida panthers numbered <30 individuals suffering from inbreeding depression. In 1995, eight pumas from Texas were translocated into southern Florida to mitigate the effects of isolation. This translocation reduced inbreeding depression and increased population size. While genetic rescue is often suggested as a means of ameliorating the effects of small population size, the underlying genetic mechanism and its long-term efficacy remain understudied. We sequenced the genomes of posttranslocation Florida panthers (PTFPs) to elucidate the genomic consequences of genetic rescue. We inferred local ancestry across the genomes of PTFPs and found that no regions have been entirely replaced by Texas ancestry, discarding the possibility of genetic swamping. Furthermore, the beneficial effects of the translocation were likely caused by a reduction in homozygosity, alleviating recessive deleterious load, rather than by a reduction in the number of deleterious variants. We did not find evidence that selection has favored replacement of original Florida DNA with Texas DNA in any systematic fashion. Using simulations, we found that heterozygosity increased in the long-term compared to a no translocation scenario; however, the effects on fitness are more transient. Our findings hold significant implications not only for the management of Florida's panther population, but also for informing strategies for genetic rescue in other wild, inbred populations encompassing broader conservation efforts.

While Dr Steinegger is well entrenched in the field of computational biology these days, his path to this field wasn't planned.In fact, when asked how he had become aware of computational biology, he said it was completely by accident!Steinegger recalls his interest in computers being a foundational aspect of his academic journey.Specifically, it started when, as a child, he received a computer with a digital operating system and was very focused on getting games running-as any young child would be!This early experience helped fuel the spark of problem-solving.Despite his interest in computers and technology, however, school was a different and more complicated story, and the path to university was anything but direct.Growing up in a small Bavarian town and being dyslexic, Steinegger was placed in an educational track that didn't give him the option to pursue a university education.Instead, he was put on a path for job placement and was told that with his education, his options for the future were going to be limited.Instead of accepting limited options, Steinegger left the restrictive German education system behind to enroll in a technical school in Austria and later turned mandatory military service into civil service which allowed him to transfer to a professional school for business informatics.From there, he ended up working as an IT consultant, and though he enjoyed this position, it wasn't the challenge he anticipated.Leveraging his professional schools' education, and encouraged to do so by a former partner, Steinegger pursued a university education to find the challenge he was looking for.

The ISCB Overton Prize recognizes early or mid-career scientists as emerging leaders in computational biology

Chimamanda Ngozi Adichie showed how a single story is limited and thereby distorts the true nature of an issue. During this COVID-19 pandemic there have been, at least, three consecutive single stories-the 'lethal threat' story, followed by the 'economic threat' story, and finally the 'vaccine miracle' story. None of these single stories can convincingly and permanently capture the dynamics of the pandemic. This is because countries experienced different morbidity and mortality patterns, different socioeconomic disadvantage, age and vulnerability of population, timing and level of lockdown with economic variability, and, despite heavy promotion, vaccines were beset with a significant and variable degree of hesitancy. Lack of transparency, coherence and consistency of pandemic management-arising from holding on to single storylines-showed the global deficiency of public health policy and planning, an underfunding of (public) health and social services, and a growing distrust in governments' ability to manage crises effectively. Indeed, the global management has increased already large inequities, and little has been learnt to address the growing crises of more infectious and potentially more lethal virus mutations. Holding onto single stories prevents the necessary learnings to understand and manage the complexities of 'wicked' problems, whereas listening to the many stories provides insights and pathways to do so effectively as well as efficiently.

Purpose Appropriate wheelchair provision is necessary for addressing participation barriers experienced by individuals with mobility impairments. Health care professionals involved in the wheelchair service provision process require a specific set of skills and knowledge to enable wheelchair use that meets individual posture, mobility and daily living requirements. However, inconsistencies exist in academic programmes globally about providing comprehensive education and training programmes. The planned scoping review aims to review and synthesize the global literature on wheelchair service provision education for healthcare professional students, healthcare personnel and educators offered by universities, organizations and industries. Methods This scoping review will be guided by the Joanna Briggs Institute (JBI) methodological framework. Comprehensive literature searches will be conducted on various global electronic databases on health to seek out how wheelchair service provision education is organized, integrated, implemented and evaluated. Two independent reviewers will perform eligibility decisions and key data extractions. Data from selected studies will be extracted and analysed using conventional content analysis. Information related to wheelchair service provision education including curriculum development, content, teaching methods, evaluation and models of integration will be synthesized. Implications and dissemination The planned scoping review will be the first to examine all aspects of wheelchair service provision education across professionals, settings and countries. We anticipate that results will inform the content of a Wheelchair Educators’ Package, and if appropriate, a follow-up systematic review. An article reporting the results of the scoping review will be submitted for publication to a scientific journal. Implications for Rehabilitation A comprehensive examination of wheelchair service provision education could help develop strategies to address the unmet need for wheelchair services globally. Findings for this review will facilitate the planning and development of an evidence-based education package that could bridge the existing knowledge gaps related to safe and effective wheelchair service provision among health professionals involved. This review will also inform the potential barriers and enablers for effective integration and implementation of wheelchair service provision education worldwide.