Jordan Valley Semiconductors (China)

This paper examines the welfare impact of intermediate goods tariffs imposed during the U.S.-China trade war (2018-2020) on consumers, producers, and employment in both economies. Combining qualitative and quantitative analysis, we utilize government reports, corporate case studies (e.g., Apple, BYD, Whirlpool), and industry data (washing machine prices, soybean exports, employment trends) to trace tariff transmission through global value chains (GVCs). U.S. consumers bore 108–225% tariff pass-through costs, with washing machine prices rising 12% (86/unit),reducingrealincomesby1.4B monthly. U.S. producers saw short-term gains in protected sectors (e.g., steel output ↑1.9%), but net losses prevailed due to input cost surges (3.5Bdownstreamdamage)and inefficientreshoring(820K per job created). Chinese SMEs suffered profit margin declines (0.35% per 1% tariff rise), triggering 10–20% workforce reductions and supply chain relocations to Southeast Asia, exacerbating hidden unemployment. Tariffs targeting intermediate goods—deeply embedded in GVCs—impose multi-stakeholder welfare losses. Policymakers should prioritize supply chain diversification and critical intermediate goods tariff exemptions over decoupling. By focusing on intermediate goods as the core transmission channel, this study pioneers a systematic analysis of their multi-dimensional welfare impacts across economies, revealing the trade war’s true costs beyond gross trade statistics.

Drug discovery and development is a notoriously risky process with high failure rates at every stage, including disease modeling, target discovery, hit discovery, lead optimization, preclinical development, human safety, and efficacy studies. Accurate prediction of clinical trial outcomes may help significantly improve the efficiency of this process by prioritizing therapeutic programs that are more likely to succeed in clinical trials and ultimately benefit patients. Here, we describe inClinico, a transformer-based artificial intelligence software platform designed to predict the outcome of phase II clinical trials. The platform combines an ensemble of clinical trial outcome prediction engines that leverage generative artificial intelligence and multimodal data, including omics, text, clinical trial design, and small molecule properties. inClinico was validated in retrospective, quasi-prospective, and prospective validation studies internally and with pharmaceutical companies and financial institutions. The platform achieved 0.88 receiver operating characteristic area under the curve in predicting the phase II to phase III transition on a quasi-prospective validation dataset. The first prospective predictions were made and placed on date-stamped preprint servers in 2016. To validate our model in a real-world setting, we published forecasted outcomes for several phase II clinical trials achieving 79% accuracy for the trials that have read out. We also present an investment application of inClinico using date stamped virtual trading portfolio demonstrating 35% 9-month return on investment.

ZL-1211, anti-CLDN18.2 therapeutic antibody can target CLDN18.2-high as well as -low gastric cancers that may not be eligible for treatment with clinical benchmark. ZL-1211 treatment induces NK-cell activation with robust inflammation to further activate antitumor immunity in tumor microenvironment.

New and practical synthetic route of N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide (1) is described, through the cyclization of 2-aminophenyl-ethanone (12) with N,N-dimethylformamide dimethylacetal. The overall yield of 1 obtained from this process is 46% (five steps) with a purity of >99% (HPLC).

A monolithically integrated wavelength-selective photodetector, which consists of an 11.86 μm thick GaAs-based Fabry–Pérot filter and a 3.84 μm thick InP-based p-i-n absorption structure (with a 0.3 μm In0.53Ga0.47As absorption layer), was grown on a Si substrate. A crack-free and high-quality epilayer with an area of 800×700 μm2 was obtained by using midpatterned growth and thermal-cycle annealing. Long dislocations running parallel to the GaAs/Si interface were formed by thermal annealing. This kind of dislocation may effectively alleviate the thermal stress across a large patterned area and be responsible for the crack-free epilayer. A photodetector with a spectral linewidth of 1.1 nm (full width at half maximum) and a quantum efficiency of 9.0% was demonstrated.

A large cohort of 74,828 benzene-exposed and 35,805 nonexposed workers employed between 1972 and 1987 in 12 cities in China was followed to determine mortality from all causes. Benzene-exposed study subjects were employed in a variety of occupations including coating applications, and rubber, chemical, and shoe production. Mortality was slightly increased among workers with greater cumulative exposure to benzene (ptrend < 0.05), but this excess was largely due to cancer deaths (ptrend < 0.01). Deaths due to lymphatic and hematopoietic malignancies (ptrend = 0.01) and lung cancer (ptrend = 0.01) increased with increasing cumulative exposure to benzene. Investigations continue to relate benzene exposure to specific lymphatic and hematopoietic malignancies and other causes of death.