KBR (United Kingdom)

Background: Generalized myasthenia gravis (gMG) is a rare, chronic, autoimmune disease characterized by muscle weakness and fatigue. This study aims to describe the natural history, disease burden and treatment patterns of gMG patients in Canada. Methods: Data was analyzed from the Adelphi MG II DSP™, a gMG patient-level cross-sectional database, collected through surveys between February-June 2024. Neurologists provided sociodemographic, symptomatology, and treatments data. Results: Fifteen neurologists provided data for 46 gMG patients. The cohort’s mean (SD) age was 58.1 (14.7) years, 52.2% male, 82.6% White/Caucasian and 89.1% were anti-AChR Ab positive. Mean time since diagnosis was 3.4 (3.1) years, 22% reported a change in employment status due to gMG. Most had public insurance (68.9%). Disease severity was mostly MGFA class II (78.2%) patients. Common symptoms included eyelid ptosis (76.1%), dysarthria (50.0%), and dyspnea (54.3%) – mean MG-ADL was 5.6 (5.1). During their disease course, 34.9% experienced ≥1 myasthenic crisis, while 25.6% reported symptom exacerbation. At time of survey, patients had used 1.8 (0.9) lines of maintenance treatment. Most prescribed treatments (alone or in combinations) were pyridostigmine (95.6%), corticosteroids (48.9%), non-steroidal immunosuppressants (42.2%), Immunoglobulins (31.1%), and biologics (22.2%). Conclusions: gMG patients continue to experience symptoms burden and crisis/exacerbations. These findings highlight an unmet need for new, safe and effective therapeutics that are publicly covered to manage gMG-related clinical manifestations.

The text of this paper has been largely adapted from Whitman et al. ( 2022), Review of Solar Energetic Particle Models.

Scheduled for launch in January 2024, the PACE mission represents NASA’s next investment in ocean biology, clouds, and aerosol data records [1]. A key feature of PACE is the inclusion of an advanced satellite radiometer known as the Ocean Color Instrument (OCI), a global mapping radiometer that combines multispectral and hyperspectral remote sensing. This paper describes the methods used for pre-launch calibration of OCI and considerations to ensure the combination of Ground Support Equipment (GSE) and instrument effects meet uncertainty and performance requirements. General considerations when designing a calibration campaign are also discussed.

Summary This paper presents a methodology developed to estimate the optimum horizontal well length based on total economics and on the productivity index (PI) change associated with frictional loss effects in the long section of the horizontal wellbore. An integrated approach is proposed for quantitative analysis of the parameters affecting productivity and economics to achieve the overall optimum performance of a horizontal well project. This study shows that production is no longer proportional to the horizontal well length after a critical point. The critical point is calculated as a function of the length of the horizontal production section, flow rate, drawdown pressure, and other parameters. A step-by-step calculation procedure with examples is described with sets of graphical charts developed for illustrating the relationships between the various parameters.