KGK Synergize (Canada)

High serum concentration of low-density lipoprotein cholesterol (LDL-C) is a major risk factor for coronary heart disease. The efficacy of pantethine treatment on cardiovascular risk markers was investigated in a randomized, triple-blinded, placebo-controlled study, in a low to moderate cardiovascular disease (CVD) risk North American population eligible for statin therapy, using the National Cholesterol Education Program (NCEP) guidelines. A total of 32 subjects were randomized to pantethine (600 mg/day from weeks 1 to 8 and 900 mg/day from weeks 9 to16) or placebo. Compared with placebo, the participants on pantethine showed a significant decrease in total cholesterol at 16 weeks (P=0.040) and LDL-C at 8 and 16 weeks (P=0.020 and P=0.006, respectively), and decreasing trends in non-high-density lipoprotein cholesterol at week 8 and week 12 (P=0.102 and P=0.145, respectively) that reached significance by week 16 (P=0.042). An 11% decrease in LDL-C from baseline was seen in participants on pantethine, at weeks 4, 8, 12, and 16, while participants on placebo showed a 3% increase at week 16. This decrease was significant between groups at weeks 8 (P=0.027) and 16 (P=0.010). The homocysteine levels for both groups did not change significantly from baseline to week 16. Coenzyme Q10 significantly increased from baseline to week 4 and remained elevated until week 16, in both the pantethine and placebo groups. After 16 weeks, the participants on placebo did not show significant improvement in any CVD risk end points. This study confirms that pantethine lowers cardiovascular risk markers in low to moderate CVD risk participants eligible for statins according to NCEP guidelines.

Flavonoids are a group of polyphenolic compounds ubiquitous in many plants including fruits, vegetables, nuts, seeds, grains, tea and wine (Hollman & Katan, 1999). Flavonoids belong to two classes i) Flavanones and ii) Flavones. The most common flavanones are hesperetin from oranges and naringenin from grapefruit. The most common flavones, also known as polymethoxylated flavones, are tangeretin and nobiletin, present in orange and tangerine peel (Kurowska & Manthey, 2004).

* # $ * # $ * # $ * $+ $ The present study was undertaken to compare the bioavailability of calcium after supplementation with four preparations Calcium AA Chelate (18%; A), Dicalcium malate (B), Calcium AA Chelate (26%; C) and Calcium carbonate (D). After ingestion of a single dose containing 900 mg of elemental calcium, no significant differences were observed in AUC suggesting that bioavailability of all four Supplements is similar. However, there were significant differences between the groups in the maximum concentration (Cmax), time to reach maximum concentration (Tmax) and half-life of elimination. Supplement A showed the maximum increase in serum calcium concentration compared to baseline followed by Supplements B, C and D. Time required to reach the maximum serum concentration was shortest for Supplement D followed by Supplements C, A and B. This suggests that absorption of Supplement D is better compared to the other Supplements. However, the halflife of Supplement D in serum was shortest suggesting that it is cleared from the blood faster than the other Supplements. Supplement B had the longest half-life and seems to be most bioavailable followed by supplement A, C and D. This work was sponsored by Albion Advanced Nutrition. Abstract