Kamla Nehru Memorial Hospital

This paper is an assessment of the perspective of Mythology and Folklore in mainstream media popularized through the use of Novels, novel adaptations, Movies, Cartoons, Comics, and Games. We see how the Hero’s journey inspires cross-cultural consciousness and a universal journey that resonates in every culture, however diverse they are. Media often is seen as more than a literary tool, as it allows the Myths and folklore from other countries and cultures to be shared all over the world, as it incorporates new cultural ideals, values, and morals that allow the audiences to learn about other cultures. Because Modern Media incorporates aspects of myths and legends from several different cultures, it brings a widened perspective of people around the world. Mainstream media helps in the regard of spreading the knowledge of different religions and cultures to audiences of all age groups with the help of Novels (fiction), movies, and Games.

In this research, a novel class of biologically active bimetallic Cu(II) compounds has been discovered as cutting-edge antibiofilm agents with metallo-β-lactamase (MBL) inhibitory activity against the clinically isolated multidrug-resistant (MDR) gram-negative bacterium, Pseudomonas aeruginosa (Pa-CI-1). As the traditional strategies for antibiotic development are proving inadequate against the swift evolution of bacterial resistance, there is an urgent need to establish novel antibacterial strategies with mechanism different from those of prevailing antibiotics. Thus, the 2,6-bis[N-{N-(carboxymethyl)-N-(pyridylmethyl)amine}methyl]-4-methylphenol (H3L)-incorporated three bimetallic Cu(II) compounds, [Cu2L(H2O)(Cl)]·H2O (1), [Cu2L(H2O)(NO3)]·H2O (2) and [Cu2L(H2O)(CH3CO2)]·H2O (3) has been strategically designed and synthesized with an unsymmetrical coordination arrangement that synergistically modifies the electronic environment of Cu centers for the enhancement of antibacterial and antibiofilm activity. The electronic environment of Cu(II) and its adjoining atoms has been further modified by substituting Cl- in 1 by NO3 - in 2 and CH3CO2 - in 3. The standard nitrocefin assay disclosed that 1-3 significantly inhibited the activity of MBLs produced by Pa-CI-1 at the half minimum inhibitory concentration (1/2 MIC). Molecular docking study suggested an excellent propensity of these Cu compounds for binding with MBL-producing proteins such as Verona integron-encoded metallo-β-lactamase (VIM-1), Sao Paulo metallo-β-lactamase (SPM-1), imipenemase (IMP-1), AmpC, and New Delhi metallo-β-lactamase (NDM-1). However, the best possible interaction was observed for VIM-1 protein. All three Cu(II) compounds displayed significantly high antibacterial and antibiofilm activity as established by multiple bioassays, including ex vivo applicability studies. However, 1 and 3 showed an outstanding activity with MIC values of 200 and 150 µg/mL, respectively, in comparison to 2 with an MIC of 300 µg/mL. They showed an exceptional combinatorial activity when examined with five different commercially accessible β-lactam-based antibiotics, such as amoxicillin (AMX), chloramphenicol (CHL), cefotaxime (CTX), ceftriaxone (CTR), and cefoxitin (CX) against Pa-CI-1. It has been suggested that the as-synthesized Cu compounds also blocked the activity of MBLs via strong interactions with the active sites of enzymes, thus restoring the normal activity of the antibiotics. Our study disclosed that 1-3 could be the emergent drug leads and attract great attention to the materials and biological chemists, combating antimicrobial resistance (AMR).

The traditional total cross-tied (TCT) model and an advanced permutation combination reconfiguration (PCR) are employed to analyze the performance of the solar arrays under realistic partial shading conditions (PSCs). The model uses a single-diode solar cell using the MATLAB/SIMULINK tool. The performance indicators are evaluated to show the high potency of advanced PCR over TCT under various PSCs. Results show that the advanced PCR has minimized the shading loss (SL) by 9.28% and 76.78% under lamp post-shape shading and corner shading (CS) against TCT. Also, advanced PCR has maximized the global power (GP) by 14.55% which has been verified by a hardware prototype under CS. These outstanding results of the advanced PCR support the practicality of the suggested technique (PCR).

Background: About 2%–3% of all adult malignancies diagnosed worldwide are renal cell carcinomas (RCCs), the most prevalent kind of renal malignancy. Renal tumors include a wide range of benign and malignant lesions, and the patterns of these lesions differ in adults and children. The most common renal tumor in childhood is Wilms tumor. Aim and Objective: The aim of this study was to examine different types of renal tumors, their incidence, and their histomorphological characteristics, as well as their relation to the patient’s age and sex. Results: During our study period of 2 years, 60 kidney tumors were examined. Fifty-two (86.6%) of the cases were malignant, of which 38 (73.1%) were clear cell RCC. There were also three cases of high-grade urothelial carcinoma of the renal pelvis (5.7%), two cases of papillary cell RCC (3.8%), and one case of pleomorphic sarcoma (1.9%). With a peak occurrence between the ages of 2 and 5, a total of 8 (15.3%) cases were identified as Wilms tumors. Eight (13.3%) cases of benign neoplasms were found; angiomyolipomas in 4 (50%) cases and mixed epithelial and stromal tumors in 4 (50%) cases. Conclusion: With clear-cell RCC being the most frequent malignant tumor in adults, malignant renal tumors considerably exceeded benign renal tumors. In pediatric age groups, Wilms tumor was the most common malignancy. For the diagnosis, staging, and proper treatment of renal tumors, histopathological evaluation is crucial. Immunohistochemistry is an ancillary tool to accurately subtype kidney tumors.

Nepal is a country in South-east Asia with high suicide. There is ongoing trend of emerging research on suicide from Nepal but there is lack of validated scale in measuring literacy or stigma. In the view of poor media reporting and large treatment gap, this study was conducted. All previous validation studies were done in non-Hindu populations. A cross-sectional study was planned where the short forms of Nepalese literacy of suicide scale (LOSS-SF-Nep) and Stigma of Suicide Scale (SOSS-SF-Nep) were validated using standard procedure at a medical college in southern Nepal. Medical and nursing students of all batches were approached offline after successful pretesting. The psychometric properties of the scales were tested, and the statuses of literacy and stigma were assessed. Patient Health Questionnaire-9 and General Anxiety Disorder Scale-7 were used for revealing depression and generalized anxiety. Three hundred and nineteen Nepalese students participated and most of them were males, belonged to nuclear family, upper-middle socioeconomic status and represented 46 out of 77 districts of Nepal. The mean score of LOSS-SF-Nep was 6.36±1.92 and literacy ranged from 37.9% to 89.7%. The deeper exposure to suicidal patients was associated with better literacy. Factor analysis of SOSS-SF-Nep revealed three subscales: stigmatization, isolation/depression, and normalization/glorification and had acceptable psychometric properties. Gender, occupation of head of the family, region and years of education, using mental health services, and depression were associated with variable literacy or stigma. Literacy and stigma scales were validated in Nepali, and SOSS factor structures were revealed with modified descriptors. The literacy and stigma levels in medical students were calculated for the first time in Nepal and Hindu majority population.

Swed, Sarya MDa; Rais, Mohammed A. MDb; Aljabali, Ahmed MDc,; Siddiq, Abdelmonem MDd; El-Sakka, Amro A. MDe; Patwary, Muhammad M. MDf,g; Elsayed, Mohamed MDh; Shoib, Sheikh MDi Author Information

Background and AimCOVID-19 has shown how crucial awareness of the need to protect public health is to global security. Antibiotic resistance due to antibiotic misuse is seen as a worldwide health issue. Antibiotic use was significant during the COVID-19 epidemic, according to several nations. This research aims to investigate public attitudes on COVID-19, antibiotic resistance, and preventive measures during the COVID-19 pandemic in the Middle East.MethodsAn online quantitative cross-sectional study in 17 Arabic nations was carried out between January 3 and March 4, 2022, using a structured questionnaire to evaluate participants’ knowledge of COVID-19, their attitudes toward the new standard during the pandemic, and their use of antibiotics, and their resistance to them. The research was available to all Arabic people over 18 nations in the middle east. A convenient snowball sampling technique was used. SPSS version 20.0 was used to analyze the data. To analyze the results, binominal logistic regression was utilized. Statistical significance was defined as a p value of 0.05.ResultsOf the 6145 responders, 24.1% believed COVID-19 might spread to asymptomatic people, whereas 13.6% thought using antibiotics would accelerate recovery from any illness. Moreover, half of the respondents said antibiotics only work against bacteria (64.6%). 70.8% of participants adopted the necessary safety measures. More than a third of respondents strongly supported placing foreign immigrants in quarantine (33%). However, more than 50% of those surveyed (52.5%) firmly supported using face masks in all public settings. Individuals with a medical education background had 2.6 times more appropriate understanding of antibiotic resistance than others. Furthermore, participants in the 30–49 age range had a better handle on the use of antibiotics and antibiotic resistance than other respondents by 1.1 times.ConclusionArab Health authorities should reconsider this health issue as soon about the inadequate level of awareness toward antibiotic use, resistance, and preventative practices during COVID-19. Many suggested strategies, especially solving the irregular antibiotic prescriptions during a COVID19 pandemic, should be implemented to increase public awareness of COVID19.

In chapter, we have described a thermodynamic based Gibbs free energy change (\(\Delta\)G) during in aqueous dissociation of benzoic acid (C6H5COOH) in between of 288 upto 318 Kelvin temperature range. The dissociation constant (Ka) of benzoic acid for aqueous solutions have been determined by applying of titration method against standard basic solution of NaOH at different concentrations as 0.05, 0.10, 0.30, 0.40 and 0.50 of NaCl. In observation, the value of Ka is being inversely proportional with increase the temperature (289 K - 303 K), and above at higher temperature in between 303 K to 314 K, it being directly proportional. This is report that, there are no regular correlation in this temperature range and Ka of that acid. The graph's plot displays the benzoic acid's Ka value, which is 4.176 at 298 K. Thus, in finding of precious results for benzoic acid dissociation in aqueous an applying the Gibbs free energy change relationship (\(\Delta\)G = \(\Delta\)H - T\(\Delta\)S) for endothermic or exothermic reaction process at standard condition of thermodynamic parameters. These parameters value (in kJ.mol-1) are being as \(\delta\)G = 12.507, \(\Delta\)H = 3.823 and \(\Delta\)S = -29.14. It demonstrates that acid dissociation into an aqueous solvent is an endothermic, non-spontaneous process with entropy (\(\Delta\)S) at 298 K.