Kankakee State Hospital

Introduction: Tendinopathy is a degenerative condition resulting from tendons experiencing abnormal levels of multi-scale damage over time, impairing their ability to repair. However, the damage markers associated with the initiation of tendinopathy are poorly understood, as the disease is largely characterized by end-stage clinical phenotypes. Thus, this study aimed to evaluate the acute tendon responses to successive fatigue bouts of tendon overload using an in vivo passive ankle dorsiflexion system. Methods: Sprague Dawley female rats underwent fatigue overloading to their Achilles tendons for 1, 2, or 3 loading bouts, with two days of rest in between each bout. Mechanical, structural, and biological assays were performed on tendon samples to evaluate the innate acute healing response to overload injuries. Results: Here, we show that fatigue overloading significantly reduces in vivo functional and mechanical properties, with reductions in hysteresis, peak stress, and loading and unloading moduli. Multi-scale structural damage on cellular, fibril, and fiber levels demonstrated accumulated micro-damage that may have induced a reparative response to successive loading bouts. The acute healing response resulted in alterations in matrix turnover and early inflammatory upregulations associated with matrix remodeling and acute responses to injuries. Discussion: This work demonstrates accumulated damage and acute changes to the tendon healing response caused by successive bouts of in vivo fatigue overloads. These results provide the avenue for future investigations of long-term evaluations of tendon overload in the context of tendinopathy.

In most neoadjuvant chemotherapy regimens, the taxane is administered either in combination with an anthracycline or after an anthracycline-containing regimen. We sought to test the feasibility, safety, and determine the pathological complete response (pCR) rate of administering docetaxel first followed by epirubicin as neoadjuvant chemotherapy in women with clinical stage II, III breast cancer. Twenty-five women with newly diagnosed clinical stage IIB (n = 10), IIIA (n = 5), or IIIB (n = 10) received 3 cycles of docetaxel 100 mg/M2 intravenously (IV) every 3 weeks followed by 3 cycles of epirubicin 100 mg/M2 IV every 3 weeks. pCR was defined as the absence of invasive cancer in the breast at definitive surgery. The median primary tumor size was 6 cm (range 1-12 cm), and 13 (52%) women had clinically palpable axillary lymph nodes. Patients received 149 of the 150 planned cycles of docetaxel and epirubicin without treatment delays, and only 3 (12%) patients had a dose reduction of docetaxel. Seven (28%) patients experienced febrile neutropenia, and 9 (36%) patients had grade 3 non-hematological toxicities with diarrhea being the most frequent in 3 (12%) patients. Six (24%) patients had pCR in the breast. Analysis of pre- and post-docetaxel biopsies from a subset of patients documented taxane-induced activation of mitogen-activated and stress-activated protein kinase pathways. Neoadjuvant docetaxel followed by epirubicin is well tolerated and active in breast cancer. To our knowledge, this is first description of docetaxel-induced activation of mitogen-activated and stress-activated protein kinase pathways in human breast cancer.

During the first campaign of the Asian-Pacific space geodynamics (APSG) program in October 1997, two VLBI experiments were successfully organized and coordinated by the Astrometry and Geodesy VLBI Group of Shanghai Astronomical Observatory, the Chinese Academy of Sciences, cooperated with geodetic VLBI group, GSFC, NASA, USA. Six VLBI stations participated in the experiments, including Seshan and Urumqi station of China, Gilcreek station in Alaska and Kokee station in Hawaii of USA, Kashima station of Japan and Hobart station at Tasmania of Australia. Baseline lengths are from 1 900 to 11 000 km and the mean relative uncertainty of the baseline length measurements is 1.0 x 10(-9). In addition, the rates of the baseline lengths among the six stations and their three-dimensional velocities are solved out via global analysis of the two APSG sessions and the historical observations of the six stations as well as other VLBI observations from the global observation network. These results are appreciable to the studies of the modern crustal movement in the Asian-Pacific region. Especially, an 8 mm/a eastward motion and a 14 mm/a north by northeast motion are detected respectively for Seshan and Urumqi stations relative to the stable part of the Eurasian plate. The motions directly illustrate the effect of the northward movement of Indian plate on the modern crustal motions of the northwestern and the eastern part of China, which is of important significance to the study of the modern crustal motion of China.

Every year new service models are demonstrated by energetic professionals who are seeking better ways to serve mentally retarded people (e.g., Menolascino & Stark, 1984). The new models are constantly challenging behavior modifiers to broaden their horizons or risk the possibility of becoming outdated (Reiss, 1987). In this chapter, we will consider three new models for serving people with mental retardation and discuss some of the ways in which behavior modifiers might relate to these models. The models are outpatient mental health services, inpatient mental health services, and foster care. Two of the models, outpatient and inpatient mental health services, relate to the critical need for services to people who are dually diagnosed (i.e., mentally retarded and emotionally disturbed). The third model, foster care for persons with mental retardation, provides a desirable alternative to residential placement in state institutions and other restrictive environments. Although the three models discussed here are from Illinois, similar programs have been created in many places across the United States. Thus, the models are relevant to important national trends in the field of developmental disabilities. Because two thirds of this chapter is concerned with behavior modification and service models for the dually diagnosed, our discussion begins with a consideration of general information on the importance of increasing the supply of mental health services for mentally retarded people.

It was shown in a prior study that mildly hypertensive patients performed significantly less effectively on several sensory-perceptual, cognitive, and psychomotor tests than did matched normotensive controls. To determine whether these deficits are attributable to elevated blood pressure per se, hypertensive and control subjects were recalled for reexamination 15 months after the original tests. Results indicated that those hypertensives in whom blood pressure had been lowered with antihypertensive drugs showed significant restoration of performance scores toward the levels of normotensive subjects. Hypertensives who had not received active treatment remained deficient as compared with controls. These results indicated that behavioral deficits in mild hypertension may be reversible consequences of the effects of elevated blood pressure on the central nervous system.

Tests made of the sensory-perceptual, cognitive, and psychomotor abilities of untreated young patients with essential hypertension have revealed a pattern suggesting a slight functional impairment of the central nervous system. Reduced performance was most marked for those tasks requiring speed and psychomotor coordination, particularly when the behaviors observed were self-initiated. Lowered scores were more evident among female hypertensives; no differences in performance by race were noted. The deficits measured by these sensitive tests do not appear to be great enough to intrude on everyday activity nor to impair work ability. Changes that may result from blood-pressure-lowering therapies will require further study.

Compared Halstead-Reitan Battery scores of hospitalized male schizophrenics with scores of normals and brain-damaged Ss to determine performance patterns that differentiate the groups. Schizophrenics performed less well than normals on the Categories, TPT-Memory, and TPT-Location subtests and better than brain-damaged Ss on all subtests except Categories. In general, the effects of medication produced nonsignificant results.

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