Kilgore College

Adverse events of myocarditis, pericarditis, and thrombosis, temporally associated with mRNA vaccination(s) and/or mRNA vaccine boosters, have been reported during post-marketing safety surveillance in the U.S. CDC VAERS database and 2021 CDC guidance to physicians. An interim report unexpectedly revealed inflammatory biomarker elevations in vaccine recipients. During review of considerable published research on the Sanarelli-Shwartzman phenomenon (SSP) and the use of nucleic acids as vaccine adjuvants, a novel, hypothesis is proposed. Even today, after being studied for over a century, the pathophysiology of the SSP is not fully understood. Motivated by a paper from 1950, titled “General Adaptation Syndrome” by Hans Selye, and recent published research by Korean investigators, a novel, non-conventional hypothesis was generated. Gluten and lectin sensitivity are cited as examples of sensitizing events of the SSP, for which we propose ensemble hydrophobic chiroptical catalysis may have therapeutic benefit. Under the ensemble HCC hypothesis, we propose that inflammatory stress and scurvy promote loss of chirality control, anomeric fidelity, phenotypic stability, and immune function, both humoral and cell-mediated, with the dialyzable transfer factor, L-ascorbic acid, and spin water playing central roles. It is proposed that therapeutic synergy of L-ascorbic acid, bioflavonoids, and corticosteroids in countering the SARS-CoV-2 pathogen arises from memory of chirality which originated during their biosynthesis. It is proposed that ensemble HCC is powered by radiant and or zero-point energy (quantum vacuum fluctuations) which may support a paradigm shift to supramolecular biology. The distinction between supramolecular biology and supramolecular xenobiology is highlighted.

Abstract PurposeHealth‐system pharmacists and community‐based pharmacists have long held professional relationships. However, the success of each group is often not interdependent and aligned. In 2018, the American College of Clinical Pharmacy (ACCP), CPESN USA, and the National Community Pharmacists Association (NCPA) Innovation Center led a meeting to build patient‐centered pharmacist teams to achieve medication optimization across care settings. Seven community pharmacists and health‐system/clinic‐based pharmacist teams participated in this meeting and left with the intentional commitment to build sustainable partnerships. This report describes the establishment of this partnership, and the subsequent application of Guiding Statements for these collaborations. This report also describes both the successes realized and the lessons learned, and to serve as practical recommendations for institutions interested in pursuing similar partnerships.ResultsInitial learnings from these partnerships have provided a proof of concept that an intentional approach to the relationship between a health‐system/clinic‐based pharmacist and community‐based pharmacist can lead to improvements in patient care as well as a professional collaboration. We experienced improved communication and closed‐loop care, improved professional relationships across care settings, and enhanced clinical services. However, these partnerships were not without challenges. For instance, lack of interoperability and limited electronic health record access made certain outcomes difficult to track.ConclusionThe purposeful establishment of partnerships between health‐system/clinic‐based pharmacists and community‐based pharmacists, built upon the needs of both entities, allowed institutions to develop an aligned commitment to care for shared patients. Over the initial years of these partnerships, many successes were realized and lessons were learned. Both the successes and the challenges can serve as beneficial resources for institutions interested in developing similar partnerships.

Abstract We compare methods for determining the pyroxene mineralogies of V‐type near‐Earth asteroids from their reflectance spectra. We evaluate whether band centers derived from the spectra of synthetic pyroxenes can be used to achieve greater analytical accuracy than is achieved through the use of band centers derived from the spectra of basaltic achondrites (howardites, eucrites, diogenites or HEDs). We conclude that band centers derived from the reflectance spectra of synthetic pyroxenes with known mineralogies do not provide useful diagnostic information to derive equations for determining accurate pyroxene compositions of V‐type asteroids. Band centers from the reflectance spectra of HEDs with known pyroxene mineralogies can be used to derive equations for determining accurate pyroxene compositions of V‐type asteroids. HEDs are physical mixtures of a number of different types of pyroxenes and best simulate the surfaces of V‐type asteroids. Formulas using the Band I center appear best for determining asteroid pyroxene mineralogies for V‐type asteroids due to the current difficulty in doing accurate temperature corrections to the Band II center. Most of the observed V‐type near‐Earth asteroids have interpreted mineralogies similar to eucrites or howardites. One of the observed near‐Earth asteroids could possibly have a surface mineralogy similar to diogenites.

Highway drainage structures are often located near the confluence of two streams, where the structures may be subjected to inundation by high flows from either stream. These structures must be designed to meet specified performance objectives for floods. Although many tools estimate the probability of flooding on a single stream, there is little guidance for quantifying the probability of flooding on two streams simultaneously, which is a problem of estimating the joint probability of coincident flows. The objective of the research summarized in this paper was to develop practical procedures for estimating joint probabilities of design coincident flows at stream confluences and guidelines for applying these procedures. The scope was limited to riverine areas and did not include coastal areas. Two practical strategies emerged from the analyses: (a) a strategy for determining a set of combinations of exceedance probabilities associated with the desired joint probability for design based on copulas and (b) a series of conditional probability matrices for use in the total probability method. Only the copula strategy is addressed in this paper. The use of a series of design tables makes the procedure straightforward for the designer to apply without the need for a background in statistics. An example application of the method that uses a pair of confluent streams in Washington State is provided. The application illustrates the steps needed for a designer to implement the method. The procedure advances the state of the art by providing a tool applicable to confluent watersheds in the coterminous United States.

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