Klinik für Schweine

In a fattening farm in southern Germany, paralysis of the hind limbs was observed in 2 age groups (50 kg as well as 60 kg) during a 4 week period. Despite a low morbidity of 3.3 % the majority of the affected animals needed to be euthanized in consequence to the progression of their hind limb paralysis. During pathomorphological examinations of 2 affected fattening pigs severe lymphohistiocytic meningoencephalomyelitis and vasculitis were detected. Immunhistochemistry revealed the presence of Porcine Teschovirus antigen in all parts of the central nervous system as well as in several cell types (neurons, glia cells, endothelial cells, mononuclear cells). Porcine Teschovirus was detected by PCR in spinal cord samples. The subsequently performed phylogenetic analysis PCR revealed a close relation (88 % full genome sequence) to porcine Teschovirus A11 strain "Dresden". Other swine relevant pathogens were excluded by PCR, bacteriologic examination and sequencing. Following a period of 4 weeks no additional cases of hind limb paralysis were observed in the fattening farm.

In 1588 Sebastian Weiß, the son of amiller, became the first Lutheran pastor of Dittersbach in Saxony. At home he had repeatedly witnessed successful resuscitation of drowned persons by means of simple measures by his parents. Missing appropriate recommendations in the medical literature, in 1620 as "Sebastianus Albinus" he published abooklet with measures for reviving apparently drowned persons. This Kurtze Bericht und Handgrieff (Brief report and handgrip) attracted great attention amongst physicians, especially the reprint of 1675 of which afew copies still exist. The first printed edition from 1620 was lost until, some years ago, the apparently only still existing copy was rediscovered in the Herzog August Library in Wolfenbüttel.

Die gesundheitliche Versorgung weist durch historische Entwicklungen grose regionale Unterschiede auf. In diesen gewachsenen Strukturen stellt die Sicherung der bedarfsgerechten Versorgung auf regionaler Ebene in Folge des demographischen Wandels und der hohen Komplexitat des deutschen Gesundheitssystems eine grose Herausforderung dar (SVR 2014).

A partial anomalous pulmonary venous connection (PAPVC) is a congenital abnormality of the great thoracic vessels the incidence of which is underestimated and is associated with a left-right shunt. It rarely develops into a right-sided cardiac insufficiency. Because of the mostly low left-right shunt volume, a PAPVC is often asymptomatic and mostly incidentally detected in advanced age. Incorrect positioning of a central venous catheter or paradoxical blood gas parameters can serve to indicate the presence of a PAPVC. This article presents the case a 50-year-old patient with a PAPVC of the left upper lobe pulmonary vein draining into the left innominate vein without prior clinical symptoms. Blood gas analyses from the superior vena cava, where the catheter placement was confirmed by computed tomography angiography, showed unexplainable arterial values. The anatomical abnormality was confirmed by computed tomography.

In den letzten Jahren entwickelten sich parallel zur Weiterentwicklung der Massenspektrometrie weitere analytische Hochdurchsatzverfahren, anhand derer eine Vielzahl unterschiedlicher biologischer Marker, vor allem direkte Gensequenzen und Mutationen in kurzer Zeit evaluiert werden konnen. Damit kommen diese potenziell fur Massenuntersuchungen wie das Neugeborenenscreening infrage. Gleichzeitig wurden und werden neue Behandlungsverfahren entwickelt, welche bei bislang nicht behandelbaren schweren seltenen Stoffwechselerkrankungen und verwandten Erkrankungen deutliche Verbesserungen des Behandlungsergebnisses bis hin zu langfristigen Heilungen ermoglichen. Diese technischen Fortschritte, vor allem im diagnostischen Bereich, spiegeln sich aber auch in diversen mehr oder weniger fehlerhaften bis unseriosen internetgestutzten Angeboten genetischer Screeningverfahren uber private Anbieter wieder, die nicht die Konzepte und Kriterien fur das Neugeborenenscreening erfullen, viel Geld kosten und im Einzelfall sogar mehr schaden als nutzen konnen. Zu dieser Problematik haben die Deutsche Gesellschaft fur Kinder und Jugendmedizin und die Deutsche Gesellschaft fur Neugeborenenscreening eine Stellungnahme veroffentlicht: http://screening-dgns.de/PDF/2012-Stellungnahme_Internetanbieter_Screening.pdf.

Medical records of 261 cats presenting with gastrointestinal disease that had a serum cobalamin concentration measured were reviewed. In addition, a reference range for cobalamin (305 - 1.967ng/L) was established using 22 healthy adult cats with undetectable levels of urinary methylmalonic acid. A total of 108 of 261 cats (41.4 %) had hypocobalaminemia; 69 cats (26.4 %) had cobalamin concentrations below the detection limit of the assay (<150ng/L, group A) and 39 (15 %) had concentrations between 150 - 304ng/L (group B). The remaining 153 (58.6 %) cats had normal cobalamin concentrations (group C). Diarrhea was the most common clinical sign in hypocobalaminemic cats and vomiting or anorexia was the most common sign in normocobalaminemic cats. Only cats with both, vomiting and diarrhea were more likely to have hypocobalaminemia than cats with other clinical signs (odds ratio, 2.879; 95 % CI, 1.313 - 6.310). Serum cobalamin concentration was negatively correlated with age of the patient and positively correlated with body condition score. Cats of group A had a significantly higher neutrophil count (p = 0.0009) and higher MCV (p= 0.0064) and significantly lower hematocrit (p = 0.0018) and albumin concentration (p = 0.0037) than cats in other groups. There was no difference between cats of groups B and C with respect to complete blood cell counts and metabolic profiles. Among the diagnoses made in 125 cats (A 69.6 %, B 59 %, C 35.3 %), lymphoma and inflammatory enteropathy were most common. Lymphoma was diagnosed in 31.2 % (A53.8 %, B 15.4 %, C 30.8 %) and inflammatory enteropathy in 22.4% (A 35.7 %, B 7.1 %, C 57.2 %) of cats. Hypocobalaminemia is a frequent problem in cats with gastrointestinal disease. Presenting clinical signs as well as laboratory results may already indicate its probability and severity. However, only values below the detection limit of the assay seem to affect routine bloodwork results. Cobalamin should be routinely measured in feline gastrointestinal disease, as its serum concentration may influence the choice of further diagnostics.

Seit August 2006 breitet sich die Blauzungenkrankheit (engl. Bluetongue, BT) in Mitteleuropa aus, eine ausschlieslich durch Stechmucken (Gnitzen) ubertragene und bis dahin in unseren Breiten nicht vorhandene Tierseuche von Haus- und Wildwiederkauern. Derzeit sind neben Deutschland bereits etliche weitere mitteleuropaische Lander betroffen. Die Infektion mit dem exotischen Bluetonguevirus Serotyp 8 (BTV-8) wird durch heimische Culicoides-Mucken ubertragene und ausert sich in klinischen Symptomen, die teilweise auch auf andere bedeutende Seuchen hindeuten konnten, so dass eine rasche labordiagnostische Abklarung erfolgen muss. Die staatliche Tierseuchenbekampfung versucht durch dauernde Uberwachung, Handelsbeschrankungen und neuerdings auch durch Impfung der empfanglichen landwirtschaftlichen Nutztiere die Blauzungenkrankheit in Mitteleuropa einzudammen.

The aim of this study was to investigate the incidence and influence of different causative organisms involved in the development of pneumonia and bronchopneumonia in pigs. Bronchoalveolar lavage fluid (BALF) from 339 pigs was examined molecular-biologically and culturally. The evaluation considered the following pathogens: Mycoplasma (M.) hyopneumoniae, Mycoplasma (M.) hyorhinis, PRRSV (US-Type), PRRSV (EU-Type), PCV-2, Influenzavirus Type A, alpha-haemolytic Streptococci, beta-haemolytic Streptococci, Pasteurella (P.) multocida, Bordetella (B.) bronchiseptica, Haemophilus (H.) parasuis and Actinobacillus (A.) pleuropneumoniae. This was followed by a pathological-anatomical examination in 168 pigs. Pathological-anatomical examination was evaluated for possible interstitial pneumonia, catarrhal-purulent bronchopneumonia and pleuritis. alpha-haemolytic Streptococci, PCV-2, H. parasuis, M. hyorhinis, M. hyopneumoniae, B. bronchiseptica, PRRSV (US-Type), P. multocida, PRRSV (EU-Type) and Influenzavirus Type A were evident in descending incidence in the BALF. A. pleuropneumoniae were only isolated culturally in two cases in the BALF. The frequency and semiquantitative detection rate in the bacteriological culture of alpha-haemolytic Steptococci, M. hyopneumoniae, P. multocida and B. bronchiseptica correlated significantly with the ascertained clinical evaluation score and the pathological-anatomical examination score. M. hyorhinis and Influenzavirus Type A only correlated with the severity degree of clinical appearance, while PCV-2 and PRRSV (US-Type) correlated with the frequency of pathological-anatomical changes. The higher the clinical score, the higher was the number of animals ascertained with five or more different pathogens. The more different causal agents were isolated in the BALF of one animal, the higher was the average pathological-anatomical examination score. For the diagnosis of pneumonia, especially when analysing facultative pathogens or secondary pathogens, a useful interpretation of analysis results is only possible in connection with a clinical and pathological evaluation.

Die Globalisierung der Wirtschaft ist eine Tatsache; und deshalb durfte es heute kaum noch Unternehmen geben, die es sich leisten konnen, strategische Uberlegungen anzustellen,ohne das internationale Umfeld im weitesten Sinne mit in ihre Strategiediskussion einzubeziehen. Im Gegenteil: Die Berucksichtigung des auslandischen Umfelds wird i. d. R. Teil unternehmensstrategischer Planungen sein mussen, weil die Firmen — in unterschiedlichem Ausmas — faktisch bereits in das internationale Umfeld eingebunden sind. Und dies auf mehreren Ebenen.