Korea Agency for Infrastructure Technology Advancement

An automated signal-acquisition method for the NASA’s space geodesy satellite laser ranging (SGSLR) system is described as a selection of two system parameters with specified probabilities. These parameters are the correlation parameter: the minimum received pulse number for a signal-acquisition and the frame time: the minimum time for the correlation parameter. The probabilities specified are the signal-detection and false-acquisition probabilities to distinguish signals from background noise. The steps of parameter selection are finding the minimum set of values by fitting a curve and performing a graphdomain approximation. However, this selection method is inefficient, not only because of repetition of the entire process if any performance values change, such as the signal and noise count rate, but also because this method is dependent upon system specifications and environmental conditions. Moreover, computation is complicated and graph-domain approximation can introduce inaccuracy. In this study, a new method is proposed to select the parameters via a conditional equation derived from characteristics of the signal-detection and false-acquisition probabilities. The results show that this method yields better efficiency and robustness against changing performance values with simplicity and accuracy and can be easily applied to other satellite laser ranging (SLR) systems.

Background: Low thyroid hormone (TH) function is recognized as a significant contributor in the pathogenesis after acute myocardial infarction (MI). Endothelial dysfunction contributes significantly to the poor prognosis of MI. We hypothesize that long-term treatment with low dose T3 improves endothelial function and cardiac contractile activity compared to beta blocker, the current recommended therapy for MI. Methods: Adult female Sprague-Dawley rats were subjected to left anterior descending coronary artery ligation (MI) or sham surgeries. Survivors were randomly assigned to vehicle (MI, n=11), T3 (MI+T3, n=11) and metoprolol (MI+Meto, n=11). Vehicle, T3 (5 ug/kg/day) and metoprolol (2 mg/kg/day) were supplied in drinking water ad libitum immediately following MI for 2 months. Heart function and LV hemodynamics were measured. Isolated thoracic aortic rings were used to test relaxation response to acetylcholine (ACh) in a wire myograph. The maximal effect elicited by ACh (E max ) and the sensitivity to ACh (pEC 50 ) were analyzed. One-way ANOVA with Bonferroni correction was used for multiple comparisons. Results: Serum concentration of free and total T3 were normal in all the experimental groups. T3 and metoprolol improved LV contractile function measured by fractional shortening (21.88±2.06 vs 17.88±1.23%, p<0.01, T3 vs MI; 21.12±3.88 vs 17.88±1.23%, p<0.05, Meto vs MI; 46.86±1.84% for sham) and LV +d p /d t (7307±1128 vs 5479±810 mmHg/s, p<0.01, T3 vs MI; 7022±695 vs 5479±810 mmHg/s, p<0.05; Meto vs MI; 9160±1881 mmHg/s for sham). Aortas from vehicle-treated group exhibited a marked impairment of endothelial-dependent relaxation measured by pEC 50 (6.65±0.22 vs 7.19±0.16, p<0.001, MI vs Sham), which was significantly improved in the T3 treated group (6.96±0.22 vs. 6.65±0.22, p<0.01, T3 vs MI) but not in metoprolol group (6.85±0.21 versus 6.65±0.22, p=0.22, Meto vs MI). T3 and metoprolol increased maximal relaxation measured by E max (90.56±3.55 vs 79.50±3.98%, p<0.001, T3 vs MI; 89.81±6.75% vs 79.50±3.98%, P<0.001, Meto vs MI; 96.93±1.91% for sham). Conclusion: Long-term treatment with a physiological dose of T3 following MI is equally effective as metoprolol on LV function while improving endothelial function as an additional benefit.

Alpha7 nicotinic acetylcholine receptor (α7 nAChR), an integral component of the cholinergic nervous system is known to mediate cholinergic anti-inflammatory activity in various disease models such as sepsis, stroke and neurocognitive disorders. We report for the first time that the α7 nAChR -/- deficient mouse serves as a novel model of hypertension and aneurysm formation. Seven month old male WT and α7 nAChR -/- mice weighing 28-33g were infused with low dose Ang II (350 ng/kg/min) or high dose (700 ng/kg/min) or vehicle for 15 days using mini-osmotic pumps (Alzet, model 2004) implanted subcutaneously. Blood pressure (BP) was recorded on day 0,3,7,10 and 14. Mice were euthanized on day 15. Heart and body weights were measured, histological analysis was performed on the aortas and immune profile of peripheral blood was analyzed by flow cytometry. High dose Ang II resulted in 70% mortality from aneurysm rupture in α7 nAChR -/- mice starting as early as the 4 th day of infusion. While cardiac hypertrophy was not observed, low dose Ang II resulted in a sharp rise in blood pressure in α7 nAChR -/- beginning on the 3 rd day to 167±3.7 mmHg compared to 138±3.3 mmHg in WT treated mice. On day14 of low dose treatment, BP in α7 nAChR -/- rose to 171±4.2 vs.135±3.1 in WT mice. No changes were observed in BP of untreated WT or α7 nAChR -/- animals. Histological analysis revealed high grade aneurysm in aortas of α7 nAChR -/- mice treated with low dose Ang II, demonstrating a prominent germinal center within the false lumen and fibrous desmoplastic stroma. Increased infiltration of CD11B + monocytes, and myeloperoxidase + stained neutrophils were observed in these aortas but not in the aortas of similarly treated WT mice. Flow cytometric analysis showed 27% ± 3.9 CD11B + /CD45 + circulating monocytes and 48% ± 0.8 Ly6G + /CD45 + neutrophils in α7 nAChR -/- vs. 19% ± 3 monocytes and 11.85% ± 2.9 neutrophils in WT mice. No differences in the levels of circulating immune cells were observed in untreated mice of either genotype. These data support a protective role of α7 nAChR in hypertension and aneurysm, potentially acting through its cholinergic anti-inflammatory activity. The α7 nAChR -/- mouse may serve as a new genetic model of aneurysm relevant in studies of the human disease.

Infrastructure including public facilities has become ubiquitous. Remote measurement instruments based on automatic or real-time-oriented methods also substitute for the conventional tunnel measurement approach, and thereupon the requirements for efficient measurement and analysis processes on examining civil structures are increasingly needed. With the New Austrian Tunneling Method, in particular, huge amounts of measurement data are processed to estimate the safety of a tunnel support system under construction and operation. Therefore, the analysis model for a tunnel monitoring system ought to be lighter and faster. For this reason, this study developed a two-dimensional tunnel analysis model to substitute for the conventional model (the beam-spring model), and proposed an application of the model to a tunnel monitoring system. In the proposed model, Winkler-based beam elements were applied as an alternative to beam and spring elements. A process is also proposed to determine the ground state of the Winkler-based beam element. This process is related to simulation of the ground resistance loss in tensile ground areas. Four examples were examined to verify the model: one finite beam on tensionless foundation (Example 1); two circular tunnels (Examples 2 and 3); and one horseshoe-shape tunnel (Example 4). Numerical analysis was implemented with a specific code which developed using finite element method. Comparing the numerical results with those of the corresponding beam-spring models, in Example 1, the convergence rate of the proposed model was at least fourth times. In other examples, the results of the proposed model showed a nearly perfect agreement with those of the beam-spring model, whereas the computational efficiency of the proposed model was superior by twofold. Thus, our results suggest that the use of Winkler-based elements in a tunnel model could help enhance the performance of tunnel measurement systems.