Krka (Slovenia)

Research Question (RQ): Which factors have a significant impact on the concept of quiet quitting in organizations? Purpose: The purpose of the integrative literature review is to examine in more detail the concept of quiet quitting in organizations. The objective of the comprehensive review is to identify the dimensions of the concept and to identify the factors influencing it, based on the relevant literature. The primary research methodology is based on an integrative literature review. Data collection followed the guidelines dictated by the established formal procedure or standard PRISMA. The main tool for retrieving relevant literature for our study is the prepared matrix of research databases and the keywords used in the search. Literature was searched in SpringerLink, Scopus, ProQuest, ScienceDirect, Cobiss, dLib, Google Scholar, Emerald, and ResearchGate databases. We defined the timeframe of the search as 2019 to 2023. We excluded literature that is not directly relevant to our field of research and does not have open access. We analysed the collected data using the meta-synthesis method. Results: Among the factors that have a significant impact on the concept of quiet quitting, we identified: poorly valued employees, lack of organizational commitment to employee career development, disengagement of employees, exclusion of employees in organizational decisions, lack of autonomy at work, and a decline in trust in the organization. It follows that identifying the needs of employees is a key concept on which to build strategies that lead to successful and effective management of quiet quitting. Organization: Our research provides insights into the dimension of the concept and illustrates the influencing factors that enable organisations to identify the concept in their midst in a timely and successful manner. Society: The potential reduction in the contribution of individuals to the economy has a negative impact on the economy and also on society as a whole. Originality: The topic is under-researched and we consider that further in-depth research in this area is needed. There is a perception that the topic is being studied, but at the same time, it is noted that this is not being followed up by scientific research. Original articles were included in the analysis and all non-open access literature was excluded. The integrative review prepared allows for further in-depth research in this area and forms the basis for the elaboration of a Ph.D. thesis.

\nOzadje in izvirnost: Dobro počutje na delovnem mestu predstavlja pozitivne in povezovalne koncepte ter zajema več dejavnikov, kateri pomembno prispevajo k zdravju in kakovostnemu življenju zaposlenih. Namen raziskave je opredeliti dimenzije dobrega počutja na delovnem mestu na podlagi pregleda stališč različnih avtorjev, pri tem identificirati dejavnike s pozitivnim in dejavnike z negativnim vplivom na dobro počutje zaposlenih ter z njimi povezane posledice za organizacijo.\n
\n\nMetoda: Raziskava temelji na sistematičnem pregledu obstoječe literature. Iskanje je bilo omejeno na iskalno bazo SpringerLink. Na podlagi postavljenih raziskovalnih vprašanj smo določili ključne besede in časovni okvir iskanja, ki je zajemal znanstvene in strokovne članke odprtega tipa, objavljene med leti 2010 in 2022. Iskalni niz je ponudil 123 takih člankov. V nadaljnjo obravnavo smo vključili članke, v katerih različni avtorji prikazujejo vidike in dejavnike vpliva na dobro počutje. Kriterijem je ustrezalo 37 člankov. Rezultate glavnih ugotovitev smo prikazali v tabelah.\n
\n\nRezultati: Zaznani dejavniki, ki pozitivno vplivajo na dobro počutje zaposlenih so avtonomija in visok nadzor nad lastnim delom, intervencija kovčinga, fleksibilno delo, intervencija obvladovanja tveganj povezanih z utrujenostjo, podpora vodstva, intervencije pozitivne psihologije, oblikovanje politik zmanjševanja delovnih zahtev, optimizem in pozitivna čustva, dobri medosebni odnosi, povratne informacije in uresničevanje ciljev. Kot glavne dejavnike z negativnim vplivom smo identificirali vedenje nadzornikov, psihosocialna tveganja/delovni stres, nižje ravni informacijske in medosebne pravičnosti, negotovost zaposlitve, slab poklicni ugled in nespoštljivo vedenje. Dejavniki v povezavi z dobrim počutjem zaposlenih, ki kažejo vplive na organizacijo so kadrovska fluktuacija, absentizem, prezentizem, vpliv na produktivnost, predčasna upokojitev, angažiranost zaposlenih in kakovost opravljenega dela.\n
\n\nDružba: Članek predstavlja doprinos k razumevanju pomembnosti ustvarjanja zdravih delovnih mest. Z uvajanjem različnih pristopov, ki bazirajo na spodbujanju dobrega počutja zaposlenih na delovnem mestu, se krepi njihovo zadovoljstvo, ki rezultira v večji pripadnosti organizaciji in zavzetosti pri delu ter hkrati prispeva k zmanjševanju absentizma, kot posledice nezadovoljstva pri delu. Ravno tako prispeva k vsesplošni pozitivni naravnanosti, zmanjševanju obsega in intenzitete stresorjev, kar pa bistveno pripomore k boljšemu zdravstvenemu stanju obče populacije.\n
\n\nOmejitve/nadaljnje raziskovanje: Raziskava je omejena na pregled obstoječe literature ene izmed elektronskih baz podatkov. V nadaljevanju raziskave bi lahko vključili ostale baze, elemente, ki spodbujajo dobro počutje zaposlenih na delovnem mestu pa dejansko implementirali v določeno organizacijo. S preverjanjem stanja pred in po uvedbi, znotraj določenega časovnega okvirja, bi s tem odprli nove možnosti za ugotavljanje statističnih značilnosti ter uspešnosti same implementacije.\n
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The importance of roller compaction is recently increasing. This study evaluates the combined effects of formulation factors, process parameters, and selected quality attributes on drug release from roller-compacted hypromellose-based matrix tablets containing carvedilol as a model drug. The influence of selected factors was statistically assessed and good predictive models were developed for various time points of the release profile. The results show that the release profile is mostly affected by the particle size distribution of granules and roll speed. This indicates that the roller compaction process has a major impact on drug release, which is also formulation dependent. A higher d50 and lower d90 value of spatial filtering technique-based particle size distribution results, a lower roll speed, increased hypromellose content, using microcrystalline cellulose as a filler, and higher tablet hardness, resulted in a decrease in the drug release rate. On the other hand, the effect of the roll pressure, size of screen apertures, and d10 values on drug release was insignificant. The significance of the factors was further explained by granule shape, their porosity, and friability evaluation, and by compressibility and compactibility studies of compression mixtures. Additionally, the spatial filtering technique demonstrated to be a promising tool in controlling the roller compaction process.

Izhodišča: Večino bolnikov z nezapleteno arterijsko hipertenzijo obravnavamo zdravniki družinske medicine. Namen raziskave je bil ugotoviti, kako poteka obravnava bolnikov z arterijsko hipertenzijo v timu družinske medicine v Sloveniji ter oceniti urejenost krvnega tlaka.
 Metode: V prospektivni opazovalni raziskavi smo v obdobju od 21. 11. 2017 do 28. 3. 2019 šest mesecev spremljali obravnavo dotlej še nezdravljenih bolnikov z esencialno arterijsko hipertenzijo v 158 ambulantah družinske medicine v Sloveniji. Ob koncu spremljanja smo ocenili urejenost krvnega tlaka (KT).
 Rezultati: Vključenih je bilo 1.060 bolnikov, katerih povprečna starost je bila 58,6 ± 12,1 let. Med vključenimi bolniki je bilo 579 (55 %) moških in 481 (45 %) žensk. Povprečna vrednost sistoličnega KT ob vstopu je bila 165,2 ± 14,5 mm Hg, diastoličnega pa 96,2 ± 10,0 mm Hg. 751 bolnikov (70,8 %) je imelo pridružene dejavnike tveganja za bolezni srca in ožilja. 408 (38,5 %) bolnikov je imelo ocenjeno srčno-žilno tveganje kot veliko oz. zelo veliko. Antihipertenzivna zdravila so bila uvedena pri 1.046 (98,7 %) bolnikih; pri 418 bolnikih (39,4 %) je bilo uvedeno kombinacijsko zdravljenje dveh ali več učinkovin v prosti ali fiksni kombinaciji. 331 bolnikov (31,6 %) je med spremljanjem opravilo obisk pri diplomirani medicinski sestri.
 Raziskavo je zaključilo 929 (87,6 %) bolnikov. Povprečna vrednost sistoličnega KT ob zaključku raziskave je bila 135,4 ± 10,9 mm Hg, diastoličnega pa 81,8 ± 8,0 mm Hg, ciljni KT je dosegalo 63,3 % bolnikov.
 Zaključek: Prepoznali smo nekatere priložnosti za izboljšanje vodenja. V prihodnje bo potrebno še okrepiti timsko obravnavo bolnikov ter spodbujati zdravnike k uvajanju kombinacijskega zdravljenja, najbolje v obliki dveh oziroma treh zdravilnih učinkovin v eni tableti.

Background and Objectives: Methotrexate is widely prescribed for the treatment of moderate-to-severe psoriasis. As drug survival encompasses efficacy, safety, and treatment satisfaction, such studies provide insights into successful drug treatments in the real-life scenario. The objective was to define methotrexate drug survival and reasons for discontinuation, along with factors associated with drug survival, in a cohort of adult patients with moderate-to-severe plaque psoriasis. Materials and Methods: Data on methotrexate treatment were extracted from our institutional registry. Drug survival was estimated by Kaplan–Meier analysis, and predictors of drug survival were analyzed by Cox proportional hazards regression. Results: We included 133 patients treated with methotrexate. Due to significant effects of the year of treatment initiation, drug survival analysis was performed for 117 patients who started methotrexate in 2010 or later. Median methotrexate drug survival was 11.0 months. Overall, 89% of patients discontinued treatment, with over half of these (51%) due to lack of efficacy. Significantly longer drug survival was seen for patients who discontinued treatment due to lack of efficacy versus drug safety (p = 0.049); when stratified by sex, this remained significant only for women (p = 0.002). The patient ABCC2 rs717620 genotype was significantly associated with drug survival in both univariate log-rank and multivariate Cox regression analyses, with variant T allele associated with longer drug survival (hazard ratio, 0.606; 95% confidence interval, 0.380–0.967; p = 0.036). Conclusions: We have identified the novel association of patient ABCC2 rs717620 genotype with methotrexate drug survival. This pharmacogenetic marker might thus help in the management of psoriasis patients in daily practice.

This study explores the use of a statistical model to build a design space for freeze-drying two formulations with ibuprofen. A 2 × 3 factorial experimental design was used to evaluate independent variables (filling volume and annealing time) and responses as residual moisture content, specific surface area and reconstitution time. A statistical model and response surface plots were generated to define the interactions among the selected variables. The models constructed for both formulations suggest that 1 mL of filled volume and no annealing should be used to achieve optimal residual moisture content, specific surface area and reconstitution time. The proposed models were validated with additional experiments, in which the responses observed were mainly in close agreement with the predicted ones. Additionally, the established models demonstrate the reliability of the evaluation procedure in predicting the selected responses.

A retrospective review of antimicrobial susceptibility to the fluoroquinolones and potentiated sulfonamides of 120 isolates of the most typical porcine bacterial pathogens isolated from animals of different age groups from 2009 to 2019 at FGBI «ARRIAH» was carried out. According to the results, P. multocida, H. parasuis are highly susceptible to enrofloxacin, which can be used for empirical treatment of pasteurellosis and Glasser's disease. A. pleuropneumoniae and S. suis are also susceptible to enrofloxacin, so it can be recommended for the treatment of A. pleuropneumonia and streptococcosis. 50% of isolates of S. suis isolated from the brain tissues are susceptible to the potentiated sulfonamides, so this medication can be recommended for the treatment of streptococcosis only after susceptibility testing.