Laboratório Bacchi

This study characterized a cohort of 52 cases of HPV-related multiphenotypic sinonasal carcinoma (HMSC) from Latin America, integrating clinicopathological, immunohistochemical, HPV genotyping, and prognostic data. HMSC predominantly arose in the nasal cavity (n=20/38.46%) of patients in their sixth decade, with equal sex distribution (n=26/50%) and frequent symptomatic presentation. Histopathologically, all tumors displayed epithelial surface dysplasia (n=52/100%). Most cases featured solid proliferations (n=25/48.08%) of basaloid cells (n=46/88.46%), with frequent tumor necrosis (n=41/75.85%). Perineural (n=5/9.62%) and vascular invasion (n=3/5.77%) were uncommon. Most patients underwent surgical excision (n=19/46.34%). Recurrence occurred in 15 of 42 cases (35.71%), although the majority remained disease-free at last follow-up (n=35/85.37%). Immunohistochemistry revealed diffuse p16 expression and variable positivity for squamous and myoepithelial markers. The Ki-67 proliferation index was high overall (median 50.1 [30.7 to 66.3]). HPV genotyping identified HPV 33 as the predominant subtype (n=34/65.38%), with a subset of cases demonstrating coinfections (n=9/17.30%). Survival analysis revealed excellent outcomes (5y OS, DSS, and DFS at 90.1%, 89.7%, and 82.4%, respectively), although regional and distant metastases and HPV coinfections correlated with poorer survival. Our findings underscore the necessity of individual-subtype-specific HPV genotyping to characterize HMSC pathogenesis and refine prognostic stratification accurately.

Mục tiêu: Mô tả đặc điểm lâm sàng, dịch tễ học và căn nguyên vi khuẩn của nhiễm khuẩn tiết niệu (NKTN) ở trẻ em tại Bệnh viện Nhi Hải Phòng. Đối tượng và phương pháp: 202 trẻ từ 2 tháng đến 15 tuổi được chẩn đoán NKTN tại Bệnh viện Nhi Hải Phòng từ 10/2022 đến 9/2024, nghiên cứu mô tả cắt ngang. Kết quả: Tỷ lệ NKTN chiếm 40,5% tổng số bệnh lý thận - tiết niệu. Trẻ từ 2–24 tháng chiếm 42,1%. Tỷ lệ nữ cao hơn nam (1/1,5). Bệnh xuất hiện quanh năm, nhiều nhất vào mùa hè. Triệu chứng thường gặp: sốt (75,2%), tiểu buốt, tiểu rắt, tiểu máu. Hẹp bao quy đầu gặp ở 19,8% bé trai. Xét nghiệm: 100% bạch cầu niệu dương tính, 72,3% hồng cầu niệu. Tỷ lệ cấy nước tiểu dương tính 39,1%, chủ yếu là E. coli (75,9%), tiếp theo là E. faecalis, P. mirabilis, K. pneumoniae, S. epidermidis và P. aeruginosa. Vi khuẩn kháng nhiều kháng sinh thường dùng như ampicillin, cephalosporin thế hệ 3, quinolon nhưng còn nhạy với carbapenem, amikacin. Kết luận: NKTN là bệnh lý hay gặp ở trẻ nhỏ, nhất là bé gái dưới 2 tuổi. Tác nhân chủ yếu là E. coli. Kháng thuốc cao, cần lưu ý khi điều trị.

Advances in veterinary medicine have contributed to increased life expectancy in companion animals, leading to a higher incidence of chronic and neoplastic diseases in cats. Epidemiological studies correlating demographic and clinical factors with lymphoma in cats are needed, particularly in South America. Data from 662 cats diagnosed with lymphoma were collected from veterinary centers located in all five Brazilian geographical regions and the Federal District. This study represents one of the largest epidemiological assessments of feline lymphoma in Brazil and highlights the broad distribution of the disease across diverse regions and age groups. The predominance of mixed-breed animals and the frequent association with retroviral infections underscore the need for early diagnostic protocols and targeted health strategies to address this issue. These findings contribute to a better understanding of feline lymphoma in Brazil and may support future efforts in disease prevention, early detection, and therapeutic planning for this disease.

Understanding variation in home range size (HR) provides important insights into the underlying ecological processes driving space use. However, it remains unclear whether the interspecific allometric scaling of mammals' HR can also be consistently observed within species and for both sexes. To address this knowledge gap, we GPS-tracked 349 resident individuals across Brazil, encompassing 18 mammal species. We estimated individuals' HR and modelled intraspecific variation in HR against body mass (BM) and sex. While males showed a positive allometric scaling similar to interspecific findings reported in the literature (exponent = 1.23), females' BM had no statistically discernible relationship with HR. We suggest that males have greater energetic and evolutionary incentives to expand their HR with increasing BM, and more physical capacity to do so. Traditional studies on HR scaling that disregard individual sex may, in reality, reflect an average of two distinct patterns, while failing to accurately represent either one.

Papillary tumor of the pineal region (PTPR) is an uncommon tumor of the pineal region with distinctive histopathologic and molecular characteristics. Experience is limited with respect to its molecular heterogeneity and clinical characteristics. Here, we describe 39 new cases and combine these with 37 previously published cases for a cohort of 76 PTPR’s, all confirmed by methylation profiling. As previously reported, two main methylation groups were identified (PTPR-A and PTPR-B). In our analysis we extended the subtyping into three subtypes: PTPR-A, PTPR-B1 and PTPR-B2 supported by DNA methylation profile and genomic copy number variations. Frequent loss of chromosome 3 or 14 was found in PTPR-B1 tumors but not in PTPR-B2. Examination of clinical outcome showed that nearly half (14/30, 47%) of examined patients experienced tumor progression with significant difference among the subtypes (p value = 0.046). Our analysis extends the understanding of this uncommon but distinct neuroepithelial tumor by describing its molecular heterogeneity and clinical outcomes, including its tendency towards tumor recurrence.

Povodom obilježavanja 300 godina od nastanka ideje liberalizma,ovaj rad predstavlja prilog proucavanju povijesti politickog i ekonomskogliberalizma na prostoru Hrvatske od kraja Hladnog rata, s naglaskomna prostor Istre i Kvarnera. Polazeci od paradigme usporednog jacanjahrvatskog centralistickog nacionalizma te europske a rmacije konceptatransnacionalnih regija, kao i americke dijagnoze jugoslavenske unutarnjepoliticke situacije, rad pokazuje svojevrsno ideološko odstupanje liberalnihstranaka u Hrvatskoj, pogotovo IDS-a, u pitanjima shvacanja pojedinca,države i ekonomije. Osim na sjednicama Predsjedništva SocijalistickeRepublike Hrvatske, posebnost politicke situacije u Rijeci i Istri vidi se iu dnevnom tisku za vrijeme izborne kampanje 1990. godine gdje svakapoliticka grupacija pokušava reinterpretirati taj prostor u svoju korist.Europska liberalna ideja u Istri nošena IDS-om uvelike je nailazilana probleme tijekom 1990-ih godina da bi tijekom ulaska RepublikeHrvatske u clanstvo Europske unije IDS bio jedna od najsnažnijihproeuropskih stranka koja je i nakon više od 20 godina od svog nastankakontinuirano ostala uz izvorne ideje ekonomskog i politickog liberalizma.

Schwannomas commonly develop in the cervical region, 25% - 45% of cases are diagnosed in this anatomical region. Tracheal neurogenic tumors are exceedingly rare and can be misdiagnosed as invasive thyroid carcinomas or other infiltrating malignancies when present at the level of the thyroid gland. Here, we present a case of synchronous benign cervical schwannoma with tracheal invasion and papillary thyroid carcinoma in a patient who was initially hospitalized for COVID-19. The patient presented with dyspnea that was later found to be caused by tracheal extension of a cervical tumor. Surgical excision was performed, and the surgical team proceeded with segmental tracheal resection, removal of the cervical mass, and total thyroidectomy. The specimen was sent for pathological analysis, which revealed synchronous findings of a benign cervical schwannoma with tracheal invasion and papillary thyroid carcinoma. The literature on this subject, together with the present case report, suggests that neurogenic tumors should be included in the differential diagnosis of obstructing tracheal cervical masses. Surgical excision is the first-line of treatment for benign cervical schwannomas.

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