LeMoyne–Owen College

Dishevelled (DVL) proteins precisely control Wnt signaling pathways with many effectors. While substantial research has advanced our understanding of DVL's role in Wnt pathways, key questions regarding its regulatory mechanisms and interactions remain unresolved. Herein, we present the recent advances and perspectives on how DVL regulates signaling. The experimentally determined conserved domain structures of DVL in conjunction with AlphaFold-predicted structures are used to understand the DVL's role in Wnt signaling regulation. We also summarize the role of DVL in various diseases and provide insights into further directions for research on the DVL-mediated signaling mechanisms. These findings underscore the importance of DVL as a pharmaceutical target or biological marker in diseases, offering exciting potential for future biomedical applications.

All accounts mentioned in this paper are for and from published data only and are referenced at the end of the report. Metals in Medicine Gordon Research Conference (GRC) started in 2002 with the effort of Professor Michael J. Clark and his collaborators and it has been held biannually since then. The most recent conference was held in Proctor Academy in Andover, NH USA. We are writing this Conference Report about its most recent and vibrant activities that occurred between June 24th, and June 29th, 2018. After an immensely productive week and with a prolific number of presentations in different subfields of metals and their involvement in medicinal diagnostics and treatments, the conference met all of its objectives, one of which was that very valuable agreements for future collaborations with at least two international researchers with knowledge of Molecular Dynamics, Density Function Theory, and Molecular Mechanics Calculations have been gained. The conference had its highest number of participants and attendees since its inception. There were 50 talks and 120 poster presentations. This report is being submitted in celebration of the 85th birth year of Professor Mostafa A. El-Sayed of the Department of Chemistry and Biochemistry at Georgia Institute of Technology.

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The UV-Vis spectra, speciation diagrams, and potentiometric profiles for Cu2+-citrate complexesin aqueous solutions are presented. As the pH increases from 2.29 to 5.15, the UV-Vis spectral profile of the Cu2+-citrate complexes showed a blue shift from 820 nm to 760 nm. We have set the conditions to construct the speciation diagram as follow: Cu2+:citric acid was in 1:1 ratio with concentration of 1.0 x 10-4 mol.L-1, 0.1023 mol.L-1 NaOH solution, and pKw = 13.781 ± 0.006 taken from Sweeton, Mesmer, and Baes. The current report is the first potentiometric study that has taken into accounts two Cu-Cit dimeric species to be refined simultaneously. These spectroscopic and potentiometric data are discussed which augment what had been reported in the literature.

We are reporting the fluorescence quenching, IR, Raman, 1H-NMR, and potentiometric studies for the Zn2+:adenine and the Cd2+:adenine systems under ambient conditions. IR and Raman spectra suggest that Zn2+ and Cd2+ interact with adenine but the modes of interaction differ. Fluorescence spectra indicate that the interaction involving Zn2+ is more favorable than that of Cd2+, and this effect is due to the difference in ionic radii. 1H-NMR, potentiometry, and speciation diagrams indicate the formation of strong metal ion adenine complexes. Potentiometric titrations of the heavier member of group 12 metals (Hg2+) show similar results to that of Zn2+ and Cd2+. Some differences in the 1H-NMR experiments appeared between both (Zn2+ and Cd2+) compared to that of Hg2+. Due to the fluorescence quenching of adenine, adenine can be used as a sensor of Zn2+ and Cd2+.

this year.The PrePRINT Network is a searchable gateway to preprint servers all across the world which deal with scientific and technical disciplines of concern to the DOE.With a single query, users can search one or a collection of existing preprint servers.The Network pulses the search engines of such servers, compiles the results, and returns them to the users (see http://www.osti.gov/preprint).With the addition of preprints to OSTI's suite of web products and services, the trilogy of ways in which researchers make their results known are now accessible on the web: grey literature through the DOE Information Bridge; journal literature through Pub-SCIENCE; and preprints through the PrePRINT Network.Interestingly, a visionary recommendation was made in a 1991 report commissioned by the American Physical Society.Called the 'Loken Report', it called for the development of a National Physics Database to integrate 'all of the world's scientific literature information in an electronic information system'.Given the developments just described, that vision no longer seems such a stretch.Indeed, Loken Report author Dr Harry Thacker recently said, 'I've often thought that the only thing we got wrong in the report was the time scale.We thought we were talking about 2020 and it turned out to be more like 2000.'The DOE's Office of Scientific and Technical Information agrees that the time is near for a digital national resource for energy science and technology information.The cutting-edge products that OSTI has developed make an ideal foundation for such a resource.The remaining uncertainties are who will launch it, and how soon that will happen.

The FEDIX Annual Status Report provides details regarding an on-line information project designed, developed and implemented by Federal Information Exchange, Inc., a diversified information services company. This document details the project design activities, summarizes the developmental phases of the project and describes the implementation activities generated to fulfill the project`s objectives. The information contained in this document illustrates FIE`s continuing commitment to serve as the link that facilitates the dissemination of federal information to the education community. This report reviews the project accomplishments and describes intended service enhancements.