Linus (Norway)

In mobile multi-network multi-domain environments services can be anything and can have any name. This poses problems for the service availability and consequently service continuity since services may not be discovered in time for being used. Services offering equivalent functions and capabilities such as GSM voice, IP telephony, etc. are usually considered as different by the network system and are not interchangeable. This paper proposes a mobile service architecture which enables the discovery and consumption of equivalent services. The solution provides also seamless service continuity by incorporating dynamic discovery of equivalent services with dynamic switching of available services. The solution offers personalisation while preserving both flexibility and control of the user. Although most of the storage and processing of data are located in the network the service continuity process is initiated, controlled and decided by the mobile device's side. A proof-of-concept including a client implementation on Android is presented.

The ω‐hydroxylation of 2S‐α‐tocopherol (2S, 4′RS, 8′RS α‐tocopherol) and deuterated (d2)‐ γ‐tocopherol (d2‐γ‐T), relative to d6‐RRR‐α‐tocopherol (d6‐α‐T) was studied. Rat liver slices were incubated with d6‐α‐T, d2‐γ‐T, or 2S‐α‐T and their metabolism to 13′‐OH was measured by LC‐MS/MS. Although uptake of each form by liver slices was comparable, 2S‐α‐T and d2‐γ‐T were more readily metabolized to 13′‐OH (39 ± 15 pmol/g and 42 ± 5, respectively, p<0.01), than was d6‐α‐T (17 ±2). When these tocopherols were incubated with microsomes expressing human recombinant CYP4F2, there was greater production (p<0.001) of d2‐γ‐T‐13′‐OH (0.36 ± 0.05 pmol 13′‐OH/pmol CYP4F2) compared to d6‐α‐T‐13′‐OH (0.08 ± 0.02); however, there was no preference for 2S‐α‐T over d6‐α‐T. These data indicate that CYP4F2‐mediated ω‐hydroxylation does not differentiate between side chain stereoisomers and that structural differences in the chroman ring are more influential. This study also suggests that other factors present in liver slices, such as selectivity of α‐T transfer protein, are responsible in regulating metabolism of natural versus synthetic α‐T.Grant Funding Source: NIH, ODS, Archer Daniels Midland, and USDA

Few subcellular organelles have received as much attention in recent years as the mitochondria (Yaffe and Schatz 1984). This is particularly interesting as regards aging research since it has been suggested that this organelle may be the “Achilles heel” of the aging cell because of the damage induced by oxygen radicals originating as a by-product of respiration (Harman 1972, Miquel et al. 1980, Fleming et al. 1982). An opposite and probably more accepted view, however, is that mitochondria do not accrue such age-dependent damage since they are replaceable organelles (Comfort 1974, Kohn 1977). Despite this apparent controversy, recent experimental evidence indicates that mitochondrial disorganization may be an important aspect of senescence in postmitotic cells, such as those found in the adult insect Drosophila melanogaster (Miquel et al. 1980, Fleming et al. 1984).

A conjecture of Palásti [11] that the limiting packing density β d in a space of dimension d equals β d where ß is the limiting packing density in one dimension continues to be studied, but with inconsistent results. Some recent correspondence in this journal [7], [8], [13], [14], [15], [16], [18], [19], [20] as well as some other papers indicate a lively interest in the subject. In a prior study [3], we demonstrated that the conjectured value in two dimensions was smaller than the actual density. Here we demonstrate that this is also so in three and four dimensions and that the discrepancy increases with dimension.

The author defines orthomolecular psychiatry as the achievement and preservation of good mental health by the provision of the optimum molecular environment for the mind, especially the optimum concentrations of substances normally present in the human body, such as the vitamins. He states that there is sound evidence for the theory that increased intake of such vitamins as ascorbic acid, niacin, pyridoxine, and cyanocobalamin is useful in treating schizophrenia. The negative conclusions of APA Task Force Report 7, Megavitamin and Orthomolecular Therapy in Psychiatry, he says, result not only from faulty arguments and from a bias against megavitamin therapy but also from a failure to deal fully with orthomolecular therapy in psychiatry. Three psychiatrists comment on Dr. Pauling's presentation.