- Research Article
- 10.1016/j.annonc.2025.08.2536
1912P Inflamed immune phenotype as a novel predictive marker of immune checkpoint inhibitors for non-small cell lung cancer
- Sep 01, 2025
- Annals of Oncology
- Y Zenke + 18 more +18
Publications from 2021 to 2026
Showing 6 of 6 papers
1912P Inflamed immune phenotype as a novel predictive marker of immune checkpoint inhibitors for non-small cell lung cancer
A network of care to improve the continuity and quality of maternal and perinatal services in Makueni County, Kenya: study protocol
Background Kenya’s high maternal and perinatal mortality rates exceeds its recommended 2030 targets. The lack of effective collaboration between health facilities and workers contributes to delays and uncoordinated provision of care, leading to negative maternal and neonatal health (MNH) outcomes. Network of Care (NOC) is an effective strategy to improve health facility network efficiencies and MNH outcomes. Utilizing NOC to improve health system coordination and MNH outcomes in Kenya has not been studied. We present a study protocol for implementation research to investigate the feasibility and acceptability of establishing a county-level NOC on relationships among health facilities and workers, the feasibility of NOC for the Makueni county health system, and the impact of NOC on the quality of MNH services and emergency referrals within the county health system. Levels of communication, collaboration, and trust between NOC health facilities and levels of preparedness for management of MNH complications are also evaluated. Methods The study employed a mixed methods design with quantitative data from health worker self-administered phone surveys, health facility referral forms, and facility registers collected at baseline, then every three months from September 2021 to July 2023. Health worker focus group discussions and county management key informant interviews were conducted at baseline, midline, and endline. The study purposively selected 60 public and private health facilities in Makueni. These facilities were a sub-sample of 344 facilities with the highest maternity caseloads. A descriptive and thematic analysis of communication, collaboration, and trust between NOC health facilities and workers, and referral system changes will take place. Trend analysis of MNH indicators for Makueni from the Kenya Health Information System will be done. Conclusion This study aims at informing decision-makers locally and globally on whether NOC is feasible and acceptable as a county-level model of care in Kenya with application to similar LMIC settings.
Read moreEffect of Internal Control Structures on Financial Management in National Public Secondary School in Cost Region, Kenya
<em>Financial resources are crucial to the success of any business. Without revenue, no company has ever succeeded. As a result, financial management must be considered by institutions, enterprises, organizations, and commercial entities in order to improve their performance and, more importantly, to reduce their exposure to financial risks. The educational sector's growth and development are determined by how well income is managed. Financial management is concerned with an organization's decisions on how to raise cash, how to manage financial resources through revenue controls, and how to allocate revenue resources wisely. It is critical to any organization's success. The government of Kenya has put in place internal control system to ensure that the funds invested in education are used for the right purpose. However, accountability and management is still wanting in some national public secondary schools. The main purpose of this study was to evaluate the effect of internal control structures on financial management in national public secondary school in Cost region, Kenya. Specific objectives being to establish the effect of control environmental system on financial management in national public secondary school in Kenya and to analyze the effect of control activities system on financial management in national public secondary school in Kenya The study was carried out in 12 national public secondary schools in Coast region, Kenya. The study was guided by financial control theory. Survey research design was used on population consisting of 12 principals, bursars 12 and 12 BOM chairs. Data were collected by use of questionnaires. Inferential statistics was used to analyze the data collected. Inferential statistics comprised of Correlation analysis, ANOVA, regression analysis. </em><em>The study found that there exist a positive, strong and statistically significant association between control environment and financial management. </em><em>Similarly, the study found that there exist a positive, strong and statistically significant association between control activities and financial management. The study found that the factors under study which were control environment and control activities had a positive and strong relationship (R = 0.516) with financial management in national public secondary schools in Coast region, Kenya. Moreover, the factors studied were found to explain 51.6% of financial management in public secondary schools in Coast region, in Kenya (</em> <em> = 0.516). The regression coefficient results revealed that a change by 1 unit in financial management was as a result of changes by 0.470 unit in control environment and 0.462 unit in control activities while holding (0.109) constant. It was revealed that control environment and control activities significantly influenced financial management in national public secondary schools in Coast region, Kenya. The study therefore concluded that there exists a positive </em><em>and significant relationship between control environment and financial management in national public secondary schools in in Coast region, Kenya. This implies that when control environment improves, financial management will improve.</em>
Read moreKatharsis
Sala de Exposiciones de la Facultad de Bellas Artes de Málaga. Del 9 de Enero al 7 de Febrero de 2020
Constructivism Theory in Technology-Based Learning
Learning theories are conceptual frameworks describing how knowledge is absorbed, processed, and retained during learning. This chapter will explore constructivism theory and how it determines impact on technology knowledge in instruction. Constructivism theory states that learning occurs when one constructs both mechanisms for learning and his or her own unique version of the knowledge. It states that knowledge must be constructed by the learner. The teacher can only assist the learner to do the construction. The construction of knowledge is a dynamic process that requires the active engagement of the learners who will be responsible for one's learning while the teacher only creates an effective learning environment. As students and teachers make use of technology in the learning process, these skills become necessary and the technology becomes a learning tool. Technology can serve as coaches by locating the problem and allowing for as much rehearsal, practice, and help as necessary to accomplish the task. Technology can enhance the cognitive powers of students.
Read moreMaking us make some sense of genocide: Beyond the cancelled character of Kuseremane in Yvonne Adhiambo Owuor's “Weight of Whispers”
This essay attempts a politically and ethically responsible, identity-focused reading of one of the central texts from the new generation of post-didactic Kenyan writers: Yvonne Owuor’s extended short story, “Weight of Whispers”, which deals with the post-genocide experience of a particular refugee who is the story’s narrator. The interdisciplinary essay examines the way in which this first-person narrator is constructed alongside the extra-textual, postcolonial construction of Rwanda’s “Tutsi” and “Hutu” as racialised groups, making explicit the parallels between these two “fictionalised” processes and ultimately concluding that Owuor’s ostensibly depressing story can be read optimistically as a consequence of its democratic indeterminacy, in this way empowering the reader to contribute to post-genocide dialogue.
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