Luminit (United States)

Multinational companies (MNCs) compete each other in a very tough business environment. They try to gain new customers while maintaining the old ones and improving the relationships with them. In order to achieve customer satisfaction and loyalty, MNCs develop strong customer relationship management (CRM) strategies and techniques to further enhance the existing collaborations. In addition, companies race each other in innovations. In pursuance of providing new or enhanced products to their customers, MNCs innovate continuously. A high degree of innovation preserves customers’ interest. The current paper aims to investigate the potential connection between innovation and customer relationship management at the level of top multinational companies activating in consumer goods industry. The methodology employed is documentation based on the analysis of the web sites discourse of top MNC, followed by testing the correlation between CRM and innovation. Results show that there is a rather weak, negative correlation between CRM dimensions and innovation types in the studied MNC, with only few positive associations. Therefore, practitioners need to adapt their business strategies individually when planning to innovate or to implement CRM at company level.

À travers le monde, la céphalée est l’une des principales causes de limitations dans la vie quotidienne et/ou d’incapacité à travailler. 50% des personnes qui en souffrent ne consultent jamais de médecin et se tournent plutôt vers l’automédication. Un travail de consensus d’experts récemment publié a exploré ce phénomène plus en détail et l’a associé à un concept scientifique appelé « céphalée du 21è siècle ».

In the present article the authors tried to explain, as much as possible, the need to modernize the education system, because, once put in the situation of teaching online, many of the educational institutions and teachers did not know how to cope with the situation, and the education system seems not to have been taken as seriously. It took a lot of work to discover the fragile parts of the education system, the need for digitization and, most importantly, the need to purchase the necessary programs and gadgets for both teachers and students to move the school online.

This paper presents studies of the thermal lens effect in the volume of motor oil by holographic methods using excitation of 447[Formula: see text]nm laser wavelength. The possibility of using a hologram of initial object, as a diffractive element, for obtaining the spectral dependence of the fluorescence of the oil product was shown.

Long term exposure to salt is a demonstrated risk factor for hypertension (HT), as well as cardiovascular and renal (CVR) outcomes. We recently proposed a novel contributor to the etiology of salt-mediated HT: the Lysine Specific Demethylase-1 (LSD1). We showed that LSD1 deficiency (in mice) and LSD1 gene variants (in humans) associate - in response to short term (one week) of sodium loading - with dysregulated renal sodium handling, volume expansion and HT, and RAAS dysfunction. However, the timeline and severity of these changes during long term exposure to sodium, and the protective effects of sodium restriction in LSD1 deficient states have yet to be determined. This study aimed (1) to evaluate the timing of onset for changes in CVR health during long term sodium loading in LSD1 deficient mice and (2) to assess whether a low salt (LS) diet can prevent these effects. LSD1 heterozygous (HET) and WT mice were randomized to high salt (HS) or LS and followed longitudinally for 6 months. BP, plasma aldosterone (Aldo) and albumin/creatinine ratios (A/C) were assessed monthly. The SBP (mm Hg) increased progressively during the study, and reached significance on the 5 th and 6 th month for HS-HET and HS-WT (141±4 and 134±3, respectively, both p<0.05 vs. baseline) but not for LS-HET and LS-WT (128±6 and 120±6, respectively). The SBP effects were driven by a significant interaction between genotype and age (p<0.05). Similar results were obtained for DBP (p<0.05), suggesting a volume mediated effect. HS plasma Aldo was appropriately suppressed. The A/C (μg/mg) was progressively increased in both HS groups, one month prior to the BP change. Namely, A/C reached significance on the 4 th and 5 th month for HS-HET and HS-WT (46±4 and 48±9, respectively, both p<0.05 vs. baseline). The LS diet prevented these changes in both genotypes. Our novel study shows that long term exposure to HS induces kidney damage followed by BP increase, and that these changes are initiated earlier in the LSD1 HET, suggesting LSD1 as a critical component of mechanisms involved in CVR health. Moreover, long term sodium restriction prevented the development of both target organ damage and HT in this model, suggesting that this dietary intervention may be particularly efficient in human carriers of LSD1 gene variants.

1.5. Legislació ambiental Cantàbria (Segon semestre 2010)