MS Clinical Research (India)

BackgroundThe complex ecosystem on skin comprising tens of thousands of microorganisms plays an important role in health and disease. The last decade in particular has witnessed a surge in microbiome research, which has been elucidating the role of the microbiota in numerous skin pathologies. Of relevance to the current study, are recent evidences implicating the microbiome in skin pigmentary conditions. Melasma is one such refractory, hyperpigmentary condition with a poorly understood pathogenesis. The present study was carried out to characterize the nature of microbial dysbiosis and its impact on microbial community structure in melasma subjects.ResultsThe clinical assessment of melasma carried out using biophysical, biochemical and biomarker-based measures confirmed significant changes in melasma lesions, most notably, those linked to redox, inflammation and barrier properties. A deep characterization of the skin microbiome in melasma from human face, indicated significant differences between lesional and peri-lesional areas. Of the 377 genera identified through an agglomeration of all OTUs at the Genus level through 16S rRNA sequencing, 344 were common, while 12 were unique to lesional and 21 unique in peri-lesional areas. A significant decrease was observed in alpha diversity in melasma lesion as compared to peri-lesion areas, with an accompanying decrease in number of interconnections among them. The differences in the microbiome also appeared to correlate with several clinical parameters, notably with the melasma severity measured through modified MASI (mMASI) scoring. The observed changes in both host and microbiome, point to a potential role for the latter in melasma pathogenesis.ConclusionsOur study indicates that there are significant differences in the microbiome between lesional and peri-lesional areas of melasma subjects, with associated changes in microbial community structures. Additionally, the observed changes were seen to correlate with measured clinical parameters. These findings provide the opportunity to further probe the nature of host and microbiome links that may underlie the phenotypic manifestation, as well as provide effective routes for managing this recalcitrant disorder.

Linked Content This article is linked to Kumar et al and Sangitha et al papers. To view these articles, visit https://doi.org//10.1002/ygh2.382 and https://doi.org//10.1002/ygh2.385.

GastroHepVolume 1, Issue 6 p. 335-336 LETTERS TO THE EDITOR Re: Helicobacter pylori infection is strongly associated with metabolic syndrome, and weakly associated with non-alcoholic fatty liver disease in a US Hispanic population: Public health impact Saumya Pandey, Corresponding Author Saumya Pandey drsaumyapandey11@gmail.com orcid.org/0000-0002-1432-6330 Department of Clinical Research, Indira IVF Hospital, Udaipur, IndiaSearch for more papers by this author Saumya Pandey, Corresponding Author Saumya Pandey drsaumyapandey11@gmail.com orcid.org/0000-0002-1432-6330 Department of Clinical Research, Indira IVF Hospital, Udaipur, IndiaSearch for more papers by this author First published: 07 November 2019 https://doi.org/10.1002/ygh2.376Citations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume1, Issue6November 2019Pages 335-336 RelatedInformation

Transitioning into society after release from incarceration presents real challenges for male offenders; in California, up to 60% return to prison within 3 years after release. The risk for ongoing drug use and having sex with multiple partners is a significant challenge for ex-offenders preparing to enter the community. The aims are to describe drug use and sexual behavior (sex with multiple partners) prior to incarceration and 6 and 12 months after study enrollment using data obtained as part of a randomized controlled trial. This is a planned secondary analysis of data obtained as part of a randomized controlled trial designed to study the effects of intensive peer coaching and nurse case management, intensive peer coaching, and brief nurse counseling on hepatitis A and B vaccination adherence compared to a usual care control treatment that also included brief peer coaching and brief nurse counseling. Self-report data from subjects enrolled at one residential drug treatment facility in Los Angeles were captured at three time points: baseline and 6- and 12-month follow-up. Findings showed substantive and significant reductions in drug use and engaging in sex with multiple partners 6 months after enrollment into the study compared to the baseline data, but results did not differ by study condition. At 12-month follow-up, drug use and sex with multiple partners increased but remained less than at baseline levels. Sustaining reductions in drug use and engaging in sex with multiple partners remains a challenge after incarceration.

Turbine control system uses electro hydraulic servo sub-system which is widely used in numerous automation and process industries. One of the major problems in designing an electro hydraulic system is, quantifying the dynamic behaviour of servomechanisms as per the requirements. In existing position controller main problem is non-linearity which affects the stability of the system. The basic position controller feedback from actuator generates non linear error, which is difficult to control. This paper is focused on position control of electro hydraulic servo valve for exponential input in turbine control systems. A novel design has been proposed to overcome the nonlinearity problems in electro hydraulic servo valve. Printed Circuit Board (PCB) has been developed using Computer Aided Design (CAD) STAR tool and GERBER file has been generated for PCB manufacturing. Digital position controller has been developed and implementation has been targeted on Virtex II FPGA. Analog and digital position controller has been realized in MATLAB. FPGA implementation for the developed RTL architecture has been carried out. The design speed has been improved to 80% and it utilizes 174 slices and needs 2 clock cycles per action with the maximum clock frequency of 100MHz. SI analysis has been carried out and maximum EMI emission at 24MHz is found to be 40.1351dBμV/m.