Maryland Institute College of Art

Aging is a major driver of diseases in humans. Identifying features associated with aging is essential for designing robust intervention strategies and discovering novel biomarkers of aging. Extensive studies at both the molecular and organ/whole-body physiological scales have helped determined features associated with aging. However, the lack of meso-scale studies, particularly at the tissue level, limits the ability to translate findings made at molecular scale to impaired tissue functions associated with aging. In this work, we established a tissue image analysis workflow - quantitative micro-anatomical phenotyping (qMAP) - that leverages deep learning and machine vision to fully label tissue and cellular compartments in tissue sections. The fully mapped tissue images address the challenges of finding an interpretable feature set to quantitatively profile age-related microanatomic changes. We optimized qMAP for skin tissues and applied it to a cohort of 99 donors aged 14 to 92. We extracted 914 microanatomic features and found that a broad spectrum of these features, represented by 10 cores processes, are strongly associated with aging. Our analysis shows that microanatomical features of the skin can predict aging with a mean absolute error (MAE) of 7.7 years, comparable to state-of-the-art epigenetic clocks. Our study demonstrates that tissue-level architectural changes are strongly associated with aging and represent a novel category of aging biomarkers that complement molecular markers. Our results highlight the complex and underexplored multi-scale relationship between molecular and tissue microanatomic scales.

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The demise of the World Trade Towers grotesquely inflated the sublime! Edmund Burke’s inclusion of fear and awe as elements of aesthetics has come to dominate representational canons, but the extreme effect of the 9/11 attacks rendered the concept intolerable while subsequent architectural work seems to have reacted with the proliferation of extreme and often unsettling contortions, vertiginous cantilevers and unbalanced profiles! Standing for the machinations of the previous millennium, upon their extirpation these minimal monoliths became the most potent auspices for the next. Before falling they were extraordinarily blank formally while provoking sectarian rage toward the institutions they stood for - New York, the U.S. and multinational commerce. An improbable history of the violent demise of his buildings plagued their designer as well! Collapse made them true monuments in the funereal sense of the word and profoundly significant as the globe drifts toward dystopia, advantaging plutocracy and distilling resentment in many cultures.

Successful FundraisingVolume 31, Issue 3 p. 5-5 Applying for Federal Grants First Steps for Securing Federal Grants Kerry Nenn, Kerry NennSearch for more papers by this author Kerry Nenn, Kerry NennSearch for more papers by this author First published: 08 February 2023 https://doi.org/10.1002/sfr.32121Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume31, Issue3March 2023Pages 5-5 RelatedInformation

Diagnostic errors- inaccurate or untimely diagnoses or failures to communicate diagnoses- are harmful and costly for patients and health systems. Diagnostic disparities occur when diagnostic errors are experienced at disproportionate rates by certain patient subgroups based, for example, on patients' age, sex/gender, or race/ethnicity. We aimed to develop and test the feasibility of a human centered design workshop series that engages diverse stakeholders to develop solutions for mitigating diagnostic disparities. We employed a series of human centered design workshops supplemented by semi-structured interviews and literature evidence scans. Co-creation sessions and rapid prototyping by patient, clinician, and researcher stakeholders were used to generate design challenges, solution concepts, and prototypes. A series of four workshops attended by 25 unique participants was convened in 2019-2021. Workshops generated eight design challenges, envisioned 29 solutions, and formulated principles for developing solutions in an equitable, patient-centered manner. Workshops further resulted in the conceptualization of 37 solutions for addressing diagnostic disparities and prototypes for two of the solutions. Participants agreed that the workshop processes were replicable and could be implemented in other settings to allow stakeholders to generate context-specific solutions. The incorporation of human centered design through a series of workshops promises to be a productive way of engaging patient-researcher stakeholders to mitigate and prevent further exacerbation of diagnostic disparities. Healthcare stakeholders can apply human centered design principles to guide thinking about improving diagnostic performance and to center diverse patients' needs and experiences when implementing quality and safety improvements.

Observations with the Fermi Large Area Telescope (LAT) of the gamma-ray source 4FGL J1702.7−5655, previously classified as a candidate millisecond pulsar, show highly significant modulation at a period of 0.2438033 days (∼5.85 hr). Further examination of the folded light curve indicates the presence of narrow eclipses, suggesting that this is a redback binary system. An examination of the long-term properties of the modulation over 13 years of LAT observations indicates that the orbital modulation of the gamma rays changed from a simple eclipse before early 2013 to a broader, more easily detected quasi-sinusoidal modulation. In addition, the time of the eclipse shifts to ∼0.05 later in phase. This change in the orbital modulation properties, however, is not accompanied by a significant overall change in gamma-ray flux or spectrum. The quasi-sinusoidal component peaks ∼0.5 out of phase with the eclipse, which would indicate inferior conjunction of the compact object in the system. Swift X-ray Telescope observations reveal a possible X-ray counterpart within the LAT error ellipse. However, radio observations obtained with the Australia Telescope Compact Array do not detect a source in the region. 4FGL J1702.7−5655 appears to have changed its state in 2013, perhaps related to changes in the intrabinary shock in the system. We compare the properties of 4FGL J1702.7−5655 to those of other binary millisecond pulsars that have exhibited orbital modulation in gamma-rays.

Journal Article Diabetes: A History of Race and Disease Get access Diabetes: A History of Race and Disease. By Arleen Marcia Tuchman. (New Haven: Yale University Press, 2020. xx, 266 pp. $32.50.) Christine Manganaro Christine Manganaro Maryland Institute College of Art, Baltimore, Maryland Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 109, Issue 1, June 2022, Pages 183–184, https://doi.org/10.1093/jahist/jaac194 Published: 01 June 2022

Abstract For several years we have been running an “astro-animation” class (AstroAnimation.org) at the Maryland Institute College of Art (MICA) in Baltimore where students work in tandem with research scientists from NASA Goddard and elsewhere to create animations. These combine results of cutting-edge research with an artist’s eye to create novel presentations of scientific results. The animations have been used for scientific outreach and educational purposes, including presentations at museums, and art, STEAM, and science fiction festivals. Astronomy has broad public interest with a “wow” factor related to black holes, dark matter, life in the universe and more. Animation is an ideal medium since it combines creative approaches, is highly popular, and the films produced are readily available for distribution.