Medan Area University

MUC16 is one of the largest mammalian mucins and exhibits substantial evolutionary variation in both sequence composition and structural modularity. Comparative analysis of SEA domain composition and tandem repeat architecture is therefore essential for understanding the evolutionary diversification of this gene across mammals. This study investigates the phylogenetic relationships of mammalian MUC16 and examines how variation in SEA domains and tandem repeats contributes to lineage-specific structural divergence. MUC16 nucleotide and protein sequences from 20 mammalian species representing Primates and Rodentia were retrieved from public databases. Multiple sequence alignment and phylogenetic reconstruction were conducted using the Neighbor-Joining method with 1,000 bootstrap replicates. SEA domains were annotated using the SMART database, while tandem repeats were identified with Tandem Repeats Finder. Structural features were evaluated using descriptive statistics, hierarchical clustering, and Spearman’s rank correlation analysis. Phylogenetic reconstruction revealed a clear molecular separation between Primates and Rodentia with strong bootstrap support. Primate species generally exhibited conserved sequences and expanded SEA domain and tandem repeat architectures, whereas rodents displayed higher sequence divergence and reduced structural complexity. A moderate positive association between SEA domain number and tandem repeat count (ρ = 0.44) was observed, although this relationship did not reach statistical significance and is therefore interpreted as a biologically suggestive trend rather than evidence of coordinated evolution. Overall, the results indicate that MUC16 evolution follows lineage-dependent patterns shaped by both sequence divergence and domain-level remodeling. This comparative framework provides an evolutionary context for understanding structural diversity in mammalian mucins and offers a foundation for future functional and genomic investigations.

Recent efforts to understand what affects the outcomes of sepsis patients have begun to focus on minerals and electrolytes, particularly magnesium. This essential mineral plays a key role in maintaining physiological balance and supporting numerous biochemical functions within the body. This study aimed to investigate the correlation between serum magnesium levels and NEWS in sepsis patients. Between December 2023 and February 2024, 32 patients with sepsis were admitted to the ICU at Haji Adam Malik Hospital in Medan, North Sumatra, Indonesia. Blood samples were collected upon ICU admission to analyze serum magnesium levels. NEWS scoring data were extracted from the ICU observation sheet and categorized into low risk (NEWS 0-4), moderate risk (NEWS 5-6), and high risk (NEWS ≥7) groups. Low serum magnesium levels are often found in ICU patients with sepsis and are associated with the development of systemic inflammatory response syndrome (SIRS) and organ dysfunction. Most of the subjects were male (59.4%), with a median age of 64 years, and were classified as high risk (68.8%). No significant variations in serum magnesium levels were observed across NEWS risk groups (p = 0.205). Nonetheless, a moderate negative correlation was observed between serum magnesium levels and the NEWS score (p < 0.001). Tracking serum magnesium levels in sepsis patients is essential for assessing risk factors and identifying individuals who might benefit from intensive interventions, ultimately aiming to enhance patient outcomes.

Pemilihan laptop yang sesuai dengan kebutuhan pengguna sering kali menjadi permasalahan karena banyaknya alternatif yang tersedia serta beragam kriteria yang harus dipertimbangkan, seperti harga, RAM, prosesor, dan kapasitas penyimpanan. Permasalahan utama dalam penelitian ini adalah bagaimana menentukan rekomendasi laptop terbaik secara objektif dan sistematis berdasarkan kriteria tersebut. Penelitian ini bertujuan untuk membangun sebuah sistem pendukung keputusan dalam pemilihan laptop menggunakan metode TOPSIS (Technique for Order Preference by Similarity to Ideal Solution). Metode TOPSIS digunakan karena mampu menentukan alternatif terbaik berdasarkan kedekatan dengan solusi ideal positif dan jarak terjauh dari solusi ideal negatif. Tahapan penelitian meliputi pengumpulan data spesifikasi laptop, penentuan bobot kriteria, normalisasi matriks keputusan, perhitungan jarak solusi ideal, hingga penentuan nilai preferensi dan perankingan alternatif. Hasil penelitian menunjukkan bahwa sistem yang dibangun mampu memberikan rekomendasi laptop terbaik secara akurat dan konsisten, serta sesuai dengan perhitungan manual metode TOPSIS. Dengan adanya sistem ini, proses pengambilan keputusan dalam pemilihan laptop menjadi lebih efektif, efisien, dan objektif bagi pengguna.

Silver nanoparticles (AgNPs) exhibit strong antimicrobial properties against plant pathogens. However, studies on the application of AgNPs, synthesized using the fungus Trichoderma harzianum, to control the growth of Ganoderma boninense Pat, which causes basal stem rot (BSR) in oil palm (Elaeis guineensis Jacq.), have not been reported. Therefore, this study aimed to assess the potential of AgNPs, biologically synthesized using T. harzianum, as a biofungicide and evaluate their effect on the growth of G. boninense in vitro and in vivo. Secondary metabolite compounds were identified using Fourier transform infrared spectroscopy (FTIR) and gas chromatography-mass spectrometry (GC-MS), and the presence of AgNPs was confirmed by a brown color change, followed by UV-Vis spectroscopy, particle size analysis, and in vitro testing. The FTIR and GC-MS results showed that isothiocyanate (N=C=S) and n-hexadecanoic acid (20.51%) were present as the antifungal compounds. The AgNPs synthesized using T. harzianum were detected at approximately 410 nm and had a nanoparticle size of 77.3 nm. In vitro application of the AgNPs at a concentration of 100 mg·liter-1 exerted a significant inhibitory effect on the growth of G. boninense. This result was consistent with the findings on palm oil seedlings. The AgNPs-Th can suppress the severity of BSR disease and can stimulate the vegetative growth of oil palm plants. In conclusion, this study expanded the current understanding of antifungal effects of AgNPs synthesized using T. harzianum and revealed their potential to suppress BSR caused by G. boninense in oil palm plantations.

Penelitian ini bertujuan untuk memahami secara mendalam pengalaman subjektif istri paman (puhun) dalam tradisi pemamanen Suku Alas di Aceh Tenggara, khususnya terkait makna kebersyukuran dan kecemasan yang mereka alami. Pemamanen merupakan sistem kekerabatan adat yang menempatkan paman sebagai figur sentral dalam acara khitanan dan pernikahan, namun dalam praktik kontemporer menimbulkan beban finansial dan sosial yang signifikan bagi keluarga paman, termasuk puhun. Penelitian menggunakan pendekatan kualitatif dengan metode Interpretative Phenomenological Analysis (IPA) untuk menggali lived experience puhun melalui wawancara mendalam terhadap tiga partisipan yang dipilih secara purposive dan snowball. Analisis data dilakukan melalui tahapan membaca berulang, initial noting, pengembangan tema emergen, serta penyusunan struktur tema lintas kasus. Hasil penelitian mengidentifikasi tiga tema utama, yaitu beban finansial multidimensi, kecemasan sosial dan stres peran, serta kebersyukuran sebagai strategi koping dan pemaknaan. Temuan menunjukkan adanya dualitas emosional berupa kecemasan terhadap marwah keluarga dan tuntutan pelawat, sekaligus rasa syukur sebagai bentuk bakti, penerimaan adat, dan pemeliharaan kohesi sosial. Puhun berperan sebagai manajer risiko di balik layar yang mengatur pendanaan dan logistik acara, sering kali hingga berutang. Secara keseluruhan, pengalaman puhun dimaknai sebagai pengorbanan yang dimuliakan dalam bingkai identitas budaya Alas. Penelitian ini berkontribusi pada kajian psikologi budaya dan memberikan implikasi praktis bagi evaluasi kebijakan adat.

Influencer marketing has rapidly become a dominant strategy in the digital age, where brands leverage individuals with a large following on social media platforms to increase brand visibility, drive sales, and shape consumer perceptions. This book chapter's purpose is to delve into the development of strategic frameworks in influencer marketing, focusing on how companies can effectively leverage influencer campaigns to either enhance brand awareness or improve marketing and sales performance. The overarching objective is to provide a comprehensive understanding for practitioners, academics, and other stakeholders regarding the distinctions between these two key objectives and how influencer marketing can be tailored to achieve specific corporate goals efficiently. Additionally, the study highlights the emerging trend of determining influencer rate cards based on engagement rates, as opposed to simply relying on the number of subscribers or followers, to more accurately reflect the effectiveness of influencer-driven campaigns.

Penelitian ini bertujuan untuk mengetahui pengaruh Perceived ease of use dan Perceived security terhadap minat penggunaan dompet digital DANA pada Mahasiswa Program studi Manajemen Universitas Sumatera Utara. Sampel dalam penelitian ini menggunakan purposive sampling yang terdiri dari 86 responden yang menggunakan dompet digital DANA pada Mahasiswa Program studi Manajemen Universitas Sumatera Utara.Teknik analisis data yang digunakan adalah teknik analisis deskriptif dan teknik analisis statistik Metode pengumpulan data melalui wawancara, daftar pernyataan, dan studi dokumentasi. Pada hasil penelitian menunjukkan bahwa pengaruh Perceived ease of use dan Perceived security terhadap minat penggunaan dompet digital DANA pada Mahasiswa Program studi Manajemen Universitas Sumatera Utara secara serempak berpengaruh positif dan signifikan terhadap minat penggunaan dengan nilai Fhitung 154.920 > nilai Ftabel 3.09. Uji yang dilakukan menunjukkan bahwa Perceived ease of use dan Perceived security secara parsial berpengaruh positif dan signifikan terhadap minat penggunaan dompet digital DANA pada Mahasiswa Program studi Manajemen Universitas Sumatera Utara. Nilai Adjusted R Square yang didapat dari hasil pengujian Koefisien Determinasi (R2) terhadap minat penggunaan sebesar 0,784 berarti 78,4% dapat di jelaskan oleh Perceived ease of use dan Perceived security. Sedangkan sisanya 21,6% dapat dijelaskan oleh faktor-faktor lain yang tidak diteliti dalam penelitian ini.

Togu Domu Nauli Village, Dolok Pardamean District, Simalungun Regency, is one of the areas with great potential as a shallot producer. Shallots planted by farmers are harvested at 65 days after planting. Shallot products can be improved and made more valuable by adding fried shallots, a type of processed shallot. Hadena MSME is a business unit engaged in processing shallots into fried shallots. Hadena MSME uses shallots as raw materials from Togu Domu Nauli Village as the highest producer of shallots according to Dolok Pardamean District data. The purpose of this study was to determine the income and added value of shallots into fried shallots. Sampling in this study was carried out using two methods, namely the Simple Random Sampling method for shallot farmers, and the saturated sampling method for Hadena Fried Shallot MSME business actors. Data analysis was carried out through the application of income analysis, as well as added value using the Hayami method. The study's findings reveal that shallot farmers in Togu Domu Nauli Village earn Rp 28,147,632 per planting season, while the Hadena Fried Onion MSME earns Rp 1,194,500 per production run. The added value of the Hadena MSME in Timbang Galung Village from processing shallots into fried onions is Rp 36,000 per kilogram.

Micro, Small, and Medium Enterprises (MSMEs) play a strategic role in accelerating regional economic growth and improving community welfare. However, MSMEs in North Sumatra Province continue to face various challenges, particularly limited access to capital, low adoption of digital technology, and insufficient business assistance. This community service program aims to strengthen the MSME ecosystem through integrated empowerment initiatives, including facilitating access to financing, enhancing the use of internet-based technologies, and improving the capacity of MSME actors. The methods applied include business mentoring, training activities, and analysis of MSME performance in both short-term and long-term perspectives. The results indicate that expanded access to capital and increased adoption of digital technology contribute positively and significantly to MSME income growth in both the short and long term. Interestingly, the absence of guidance, training, and extension services shows a positive correlation with income in the short term but has a significant negative impact on business sustainability and stability in the long term. Furthermore, reliance on bank loans consistently demonstrates a significant negative effect on MSME performance across both analytical periods. These findings highlight the importance of building a sustainable MSME ecosystem through continuous mentoring, improved financial literacy, and adaptive digital transformation to ensure long-term business resilience.

Taman Baca Masyarakat (TBM) Al-Azhari Medan merupakan perpustakaan masyarakat sebagai sarana literasi yang terbuka untuk umum dan memiliki peran penting dalam mendukung kegiatan belajar dan membaca masyarakat. Namun tata kelola administrasinya masih menghadapi kendala akibat penggunaan sistem pencatatan pengunjung yang masih manual. Hal ini berdampak pada rendahnya keamanan data, inefisiensi penyimpanan, serta beban kerja ganda (redundant work) dalam rekapitulasi pelaporan. Pengabdian ini bertujuan memodernisasi tata kelola tersebut melalui pengembangan dan implementasi Sistem Informasi Pengelolaan Pengunjung Berbasis Web yang disesuaikan dengan kebutuhan mitra. Melalui metode pengembangan sistem serta pelatihan dan pendampingan intensif, kegiatan ini berhasil menggantikan mekanisme buku tamu konvensional dengan platform digital yang terintegrasi. Hasil kegiatan menunjukkan peningkatan kompetensi mitra dalam mengoperasikan sistem secara mandiri, mulai dari input data hingga otomasi laporan statistik, yang secara bersamaan meningkatkan efisiensi operasional, kecepatan akses data historis, serta menjamin akurasi dan keamanan data administrasi di TBM Al-Azhari.