Medice (Germany)

Abstract Dietary fiber deprivation compromises gut mucosal barrier integrity by promoting microbial degradation of host mucus, a process linked to various gut-related auto immune diseases. While postbiotics are considered safer alternatives to fiber for susceptible patients, their mechanistic ef- fects on a fiber-deprived gut remain poorly understood. Here, we demonstrate in a mouse model that a fermented postbiotic, alone or in combination with a prebiotic and aloe vera, counteracted the increase of detrimental properties of the microbiota on a fiber-free diet. The supplement regimen reshaped the gut microbiota, counteracting the expansion of key mucin-degrading bac- teria, including Akkermansia muciniphila and Parabacteroides goldsteinii . Metatranscriptomic analysis revealed this compositional change corresponded to a community-wide functional pivot away from expressing mucinolytic enzymes, such as sialidases, and towards utilizing alternative substrates. These microbial shifts recapitulated the effects of dietary fiber reintroduction and translated to direct host benefits, including sustentation of the colonic mucus layer and attenu- ation of diet-induced type III immune cytokine expression. Our findings provide a mechanistic rationale for using postbiotics to functionally replace dietary fiber, offering a promising strategy to support gut homeostasis in contexts where fiber intake is limited.

Studie zkoumá Ostrčilův význam pro šíření Fibichova díla. Fibich svého žáka Ostrčila pověřoval revizemi svých partitur před vydáním, a dokonce mu svěřil části některých svých děl k instrumentaci. Vedle toho Ostrčil již tehdy upravil několik Fibichových skladeb pro klavír. Poté, co Ostrčil nastoupil svou vlastní kariéru skladatele, dirigenta a uměleckého ředitele, věnoval i nadále svou pozornost hudbě svého učitele. Ostrčil byl upravovatelem a korektorem Fibichových skladeb vydávaných u F. A. Urbánka, dirigentem jeho oper v Národním divadle včetně dramaturgie fibichovských cyklů, věnoval se propagaci Fibicha v zahraničí, kdy například provedl předehru k opeře Pád Arkuna ve švédském Göteborgu.

Die Anwendung der QbD-Prinzipien kann helfen, eine analytische Methode mittels eines systematischen Ansatzes zu entwickeln, der redundante und zeitaufwändige Tätigkeiten minimiert und daher einen signifikanten Fortschritt gegenüber den traditionellen empirischen Versuchs- und Fehlermethoden darstellt.

A wide variety of therapeutic options are available for the treatment of chronic back pain, a very common condition in Western countries with high related social and economic costs. Nevertheless, it is not always possible to achieve adequate long-term pain relief in spite of intensive analgesic therapies. Subcutaneous peripheral nerve field stimulation (sPNFS) is a newly approved neuromodulative treatment for back pain. In previously reported case series, it has provided encouraging results on long-term pain relief, improvement in quality of life, and a reduced need for analgesic drugs. Although the surgical technique is simple, there is neither consensus for patient management nor a standardized procedure for the implantation procedure. After consideration of our personal experience and the published literature, a basic recommendation has now been developed. This represents the first step toward planning prospective studies and standardization of this treatment and will permit comparison of this technique and the results with sPNFS.

Ein subklinischer Mangel an B-Vitaminen kann sich in Befindlichkeitsstorungen wie Erschopfung, Antriebslosigkeit und depressiver Verstimmung ausern. In einer Praxisstudie fuhrte eine vierwochige Injektionsbehandlung mit einer Kombination aus Vitamin B6, B12 und Folsaure zu einer deutlichen Besserung der Befindlichkeit.

Familial polycythemia vera with non-germ line JAK2 V617F mutation sparing the abnormal and clonal granulopoiesis

New 3-amino- and 5-aminopyrazoles were synthesised. 3-Aminopyrazoles exert a strong anticonvulsant effect, 4-Chlorophenyl-3-(morpholin-4-yl)-1 H-pyrazole 2 distinctively blocks sodium channels and is strongly effective in the Maximal Electroshock Seizure (MES) test.