Mid Atlantic Arts Foundation

possibilidade da realizao da bipsia e, consequentemente, um maior possibilidade do diagnstico precoce, uma vez que uma paciente com bi-rads IV ou V est habilitada para o processo de puno e bipsia do ndulo mamrio.Em razo disso, o diagnstico precoce depende do rastreamento adequado e da realizao da bipsia, com nfase na elucidao do processo neoplsico em evidncia, o cncer de mama, e do tratamento mais eficiente para a mulher.

Background and Aim: Left ventricular diastolic dysfunction (LVDD) refers to abnormal filling of the left ventricle (LV) due to its impaired relaxation or increased stiffness. Animal models of LVDD are limited and underlying mechanisms remain largely unknown. We aimed to assess LVDD in Ldlr -/- mice using imaging and gene expression measurements. Methods: Sixty-nine Ldlr -/- mice were fed with a western-type diet supplemented with vitamin D 2 (30 U/g/day) for 20 weeks to induce LVDD. Eight normal mice were fed with a normal diet and used as control group. Serial echocardiograms were used to assess cardiac structure and function, histological analyses were done on LV sections, and RT-PCR was performed on LV samples. Results: Echocardiographic results show the development of LVDD over time (P values <0.05), with a modest increase in LV mass/BW and preserved systolic function. There was an increase of perivascular fibrosis (14.9%±1.0% (14.9 to 100) vs 9.0%±1.6%; (9 to 100), respectively, P<0.01) in Ldlr -/- mice compared to controls as detected by Masson’s trichrome staining, which was correlated with increased mRNA expression for TGFß1 and Smad2 and 3 (P<0.05 for all). This was accompanied by numerical increases in Type I and III collagen mRNAs ( Col I : 1.33 (1.03; 1.97) vs 1.03 (0.90; 1.11), P=0.06; Col III : 1.49±0.30 vs 1.00±0.10, P=0.14). The angiotensin II precursor Agt mRNA level was also higher (1.07±0.08 vs 0.72±0.05; P<0.01) in Ldlr -/- mice compared to controls. Conclusion: Taken together, Ldlr -/- mice fed with a western diet supplemented with vitamin D 2 develop progressive LVDD, perivascular fibrosis and mild left ventricular hypertrophy, which represents a new model of lipid-mediated diastolic dysfunction that may be used in future studies for the evaluation of novel treatments.

This article contains reflections on presence in the life and work of Edie Turner

Members who were fortunate enough to be able to attend the Association’s Meeting on January 24th were rewarded by a most illuminating lecture on American Helicopter Development, delivered by MAJOR J C SILTANEN of the U S A A FMAJOR SILTANEN is here in the capacity of Air Technical Liaison Officer to the U S Military Attache in London, in America he was engaged on work with the Rotary-wing Branch at Wright Field, being closely concerned with the military development of Sikorsky HelicoptersThe lecture took the form of an informal discourse illustrated by many interesting slides, most of which have since been published in the Aeronautical Press, receiving due credit In token of the esteem in which we hold MAJOR SILTANEN, the Council have elected him an Honorary Member during his term of office in this country