Milligan College

This descriptive-correlational study aimed to determine the relationship between master teachers' instructional leadership and teaching competencies on teacher development among selected master teachers in public secondary schools in the Division of Camarines Sur for the School Year 2025–2026. Data was collected using a researcher-made survey with a 4-point Likert scale. Descriptive statistics, Pearson correlation, and multiple regression analysis were employed. The main findings indicated that master teachers highly demonstrated both instructional leadership and teaching competencies, which were strongly correlated with teacher development (instructional leadership, r = 0.612; teaching competencies, r = 0.790; p = 0.001). Multiple regression confirmed that instructional leadership and teaching competencies are significant predictors of teacher development, collectively explaining 40.9\% of the variance. The study concluded that master teachers' instructional leadership and teaching competencies are critical factors in enhancing the professional growth, instructional practices, and motivation of their peers, leading to the development of the CESAR Improvement Plan.

SummaryEstrogen receptor alpha (ERα) phosphorylation regulates receptor activity and tissue-specific gene expression. We generated serine (S) to alanine (A) phosphorylation-deficient knock-in mice targeting two conserved ERα sites, S171 and S216, to examine their physiological roles. ERα S216A females were subfertile, with ∼30% smaller litters and diminished uterine growth in response to estradiol (E2). Single-cell spatial transcriptomics revealed a disrupted E2-regulated transcriptome in the myometrium. Metabolic profiling revealed the suppression of glycolytic and redox pathways in ERα S216A mice, with males exhibiting reduced adiposity and increased lean mass. Skeletal analysis revealed opposing effects: ERα S216A females exhibited reduced femoral bone density, while ERα S171A females showed an increase. These data demonstrate critical roles for site-specific ERα phosphorylation in modulating receptor levels and activity, as well as gene expression, which have a profound impact on murine body composition, fertility, and metabolism.

Background: Calcific aortic valve stenosis (CAVS) is characterized by the progressive accrual of aortic valvular calcium (AVC), resulting in impaired valvular compliance and mechanics and impaired cardiac function leading to heart failure (HF). In a phase 2 trial of 23 patients with moderate CAVS, ataciguat (ATA), a soluble guanylate cyclase activator, relative to placebo slowed the deposition of AVC, decreases in aortic valve area (AVA; by continuity equation), and increases in diastolic dysfunction and left ventricular (LV) mass. ATA may have other favorable effects on ventricular, valvular, and/or vascular pathophysiology relevant to patients with CAVS. Hypothesis: We hypothesized that slowing the rate of AVC deposition is associated with improvements in valvular compliance and in measures of cardiac structure and function. Methods: A phase 2 study randomized patients with moderate CAVS 1:1 to receive ATA 200 mg/day or placebo for up to 12 months (NCT02481258). The primary endpoint was change in AVC assessed by cardiac CT, and measures of aortic valve function and cardiac structure and function were also assessed. AVA was calculated by the Modified Gorlin (Hakki) equation to additionally assess valvular compliance. Correlations between AVC, AVA, and other measures of cardiac structure and function were assessed by exploratory linear mixed models. Results: Changes in AVC from baseline were negatively correlated with changes in AVA (slope = −0.0002 [95% CI −0.0004, 0.0001]; Figure 1), such that patients with the least AVC deposition had minimal changes in AVA. Reciprocally, changes from baseline in AVA were positively correlated with changes in cardiac output (CO; slope = 0.16 [95% CI 0.13, 0.18]; Figure 2). Treatment with ATA, compared with placebo, was associated with improvements in systolic function. Changes in AVC deposition correlated with changes in CO (slope = −0.0007 [95% CI −0.0021, 0.0008]; Figure 3), and measured improvements in CO were generally more observed in patients with less of an increase in AVC, which were more frequently observed in those treated with ATA compared with placebo. Conclusions: These data suggest that slowing the rate of AVC deposition with ATA may result in improvements in CO through improved myocardial function and valvular compliance. Larger controlled trials are needed to assess such favorable myocardial/valvular effects that may help to preserve functional capacity and slow progression to HF.

This review presents recent advancements in cold atmospheric pressure (AP) plasma (CAP) processes for the synthesis and surface treatment of polymer films and metal nanoparticles (NPs) in biomedical applications. We discuss the properties and applications of atmospheric pressure plasma (APP) processes, including dielectric barrier discharge (DBD) and plasma jet methods, highlighting their effectiveness in controlling surface characteristics such as wettability and functionalization.

Tracking feeds follow a moving satellite or compensate for ground station movement due to reflector distortion by wind and temperature changes. Tracking methods include step track, conical scan, extra boresight null channel tracking, or monopulse by means of multiple horn modes or multiple-element arrays. Analysis of received noise in extra channel illustrates the limits of the tracking accuracy. Pseudo-monopulse uses slow switching between azimuth and elevation tracking to reduce the number of receivers.

Various types of ground station reflectors are discussed. Antenna positioners configure rotation axes in ways to enable sky pointing. Antenna structures and how they are mounted on positioners affect wind loading. The discussion includes various manufacturing techniques including types of reflector errors affecting both surface tolerances and beam pointing. Reflector surface measurement techniques are also discussed.

A Study was conducted to assess the effectiveness of structured teaching program on knowledge regarding effect of caffeinated food on fetus among primary gravida women in selected hospital, Bangalore. Quasi experimental one group pre-test post-test design (O1 X O2) was adopted for this study. Purposive sampling technique was used to select 60 samples. Structured teaching program was implemented to the primary gravida women for 21 days. Post-test was done after a week of intervention. The data were gathered and analyzed by descriptive and inferential statistical method. The findings revealed that During pretest 17(28.33%) and 43(71.66%) of the samples had inadequate and moderate knowledge respectively. During post-test 48(80%) and 05(8.33%) and 7(11.66%) of samples had moderate, inadequate and adequate knowledge. The paired ‘t’ value for knowledge was 5.25 Which was greater than the table value 1.67 at P ≤ 0.05 level indicating the difference in mean was true difference and structured teaching program was effective in increasing knowledge regarding caffeinated food on fetus among primigravida women. Significant association was found on only family’s annual income hence research hypothesis are retained. Eating a well-balanced diet is crucial for a pregnant women and caffeine has been shown to increase epinephrine concentrations in mother and fetus resulting in decreased placental blood flow and hypoxia.

The Parents as Teachers Randomized Controlled Trial (PAT RCT) Case Study investigates the multifaceted impact of implementing the PAT RCT in Arizona, U.S.A., shedding light on both the positive and negative effects. There has been a recent focus on improving the implementation of RCTs in community settings, as this issue has not been fully addressed. This research presents a case study examining the implementation of a community-based RCT in home visitation. This study also addresses the strategies that can be employed to mitigate some of the challenges in the implementation of an RCT, offering valuable insights for future RCTs in the domain of home visiting. The PAT program, aimed at providing parent education and family engagement for children from birth to kindergarten, encompasses a range of services, including personal visits, group connections, child screenings, and community resource linkages. The Parents as Teachers Randomized Controlled Trial (PAT RCT) directly promotes health by educating parents about health and wellness as well as providing early child screenings and heath referrals, all of which enhance health outcomes through timely interventions and improved parental practices. Lessons from the study also aim to improve the implementation of future health-related RCTs, ensuring effective delivery and impactful results.