Mobile Assay (United States)

Here we describe a manufacturing process for the production of commercial filtered Cranfords cannabis cigarettes (CN). Unlike production of filtered tobacco cigarettes, standardization in the manufacture of cannabinoid containing cigarettes is lacking. The numerous cannabis strains with variable cannabinoid content, differences in cultivation methods and variability in assembly associated with hand-rolled cannabis cigarettes makes consistent cannabinoid inhalation dosing challenging. To address the growing need for standardization in the manufacture of cannabis cigarettes we developed a process for the production of filtered CN using machine-rolled tobacco cigarette equipment. The processed CN packing density, particle size distribution and curing procedures were designed to produce filtered CN that were identical in appearance and qualitatively similar in combustion properties to market-leading filtered commercial tobacco cigarettes. Quality control procedures were implemented to assure consistency in the manufacturing process and minimize variability associated with cigarette production such as inconsistencies in packing density, particle size, and combustion rate of mainstream smoke. Passive inverted smoldering assessment indicated that CN cigarettes burned at a faster rate compared to commercial filtered tobacco cigarettes of similar density. Overall, it is expected that machine-rolled standardized cannabis cigarettes with control over filler particle sizes, packing density and smoldering rates will contribute to making inhalation dosing of cannabis cigarettes more effective for therapeutic use.

Polyurethanes can be tailor-made for a wide range of flexible surface coatings, e.g., for textile substrates and leather; and for a wide variety of adhesives. Polyurethanes give unexcelled performance in almost all of these applications. A prime target of coating textiles with polyurethanes is the achievement of the quality of natural leather. A highly water vapor permeable, but water repellent textile coating has recently become possible using a direct coating process. The application of a micro porous polyurethane film on split leather by a reaction process leads to prime quality leather for shoe uppers. For many years, elastomenc polyurethanes have been the top-ranking adhesives for highly plasticized PVC articles. More recently, polyure thanes have been introduced into the market as structural adhesives, especially for the bonding of automotive body parts. A new principle of heterogeneous cross-linking of polyurethanes which has potential for one-package structural adhesives is pre sented. Aqueous polyurethane dispersions can also be tailor-made for the whole range of two-dimensional applications. They complement the high solids and the powder polyurethane coatings, as well as the solvent-free polyurethane adhesives in the fulfillment of ecological and industrial hygiene requirements.

<div class="htmlview paragraph">Significant improvements in dimensional stability of RIM urethane fascia materials can be achieved by reinforcement with milled glass fibers. This paper documents the effects of variations of part thickness and glass content on key properties related to dimensional stability. Proper combinations of base fascia material, glass content, and selective thickening of long unsupported sections can significantly improve the fit and appearance of automotive fascia and bumper cover parts, and still maintain their weight savings and damage resistance.</div>