Modine Manufacturing (United States)

Neoadjuvant chemotherapy is increasingly the treatment for patients with inoperable breast cancer. Considering the side-effects of chemotherapy, there is a need for early evaluating response to neoadjuvant chemotherapy. To determinate the diagnostic performance of 18F-fluorodeoxyglucose position emission tomography/computed tomography (FDG PET/CT) and FDG PET for evaluating response to neoadjuvant chemotherapy in patients with breast cancer. "PubMed" (MEDLINE included) database, EMBASE, and Cochrane Database of Systematic Reviews were searched for relevant articles. We assessed the methodological quality of included study with Quality Assessment of Diagnosis Accuracy Studies (QUADAS) score tool, and used "Meta-DiSc" statistic software to obtain pooled estimates of sensitivity, specificity, diagnostic odds ratio (DOR), and summary receiver-operating characteristic (SROC) curve. Seventeen studies (a total of 781 subjects) met the inclusion criteria. The pooled sensitivity was 0.840 (95% confidence interval [CI] 0.796-0.878). The pooled specificity was 0.713 (95% CI 0.667-0.756). For FDG PET/CT (10 studies included), the pooled sensitivity was 0.847 (95% CI 0.793-0.892), the pooled specificity was 0.661 (95% CI 0.598-0.720). The pooled likelihood ratio (LR+), negative likelihood ratio (LR-), and diagnostic odds ratio (DOR) were 2.835 (95% CI 1.640-4.900), 0.221 (95% CI 0.160-0.305), and 17.628 (95% CI 7.431-41.818). The area under the SROC curve (AUC) was 0.8934. For FDG PET (7 studies included), the pooled sensitivity and specificity were 0.826 (95% CI 0.741-0.892) and 0.789 (95% CI 0.719-0.849). The pooled LR + , LR-, and DOR were 3.601 (95% CI 2.601-4.986), 0.242 (95% CI 0.157-0.374), and 13.641 (95% CI 7.433-25.030). The AUC was 0.8764. Our results indicate that FDG PET/CT and PET have reasonable sensitivity in evaluating response to neoadjuvant chemotherapy in breast cancer; however, the specificity is relative low. The combination of other imaging methods with FDG PET/CT or PET is recommended.

Electronic thermal packaging design continues to look for novel solutions for enhancing the performance of microelectronic cooling solutions. Driven by increasing thermal performance requirements, particularly in densely packaged militarized electronic systems and other high density or extreme use products, thermal designers are showing that to achieve the necessary cooling, combinations of existing technologies may offer further enhancement than has already been demonstrated. This paper discusses the performance characteristics of a single phase, pumped liquid cooling system (LCS) employed in cooling microprocessors and considers the effects of including solid state cooling (a.k.a thermoelectric cooling) in conjunction with the pumped liquid system. The thermal performance of a baseline LCS without TEC is compared to the performance of a LCS with a TEC combined with two alternative "flux transformer" heat spreaders. The two alternative flux transformers included a solid copper plate and vapor chamber heat pipe. Each "flux transformer" was sandwiched between the concentrated thermal load of the microprocessor and the TEC. The paper discusses the predicted thermal performance for the various systems as well as presenting experimental results. In demonstration, the experimental results show that the addition of TEC's coupled with the vapor chamber heat pipe "flux transformer" provided the most favorable improvement in system performance over the power dissipation range tested. As the TEC electrical power was increased, the temperature gradient across the TEC's increased reducing their coefficient of performance. Eventually, the combined TEC and vapor chamber heat pipe flux transformer solution matched, and then exceeded the heat sink temperature achievable with a conventional single phase pumped liquid cooling system. For microprocessor and ASIC heat dissipations of up to 175 watts, this particular pumped liquid system incorporating TEC's coupled with a vapor chamber heat pipe flux transformer can significantly reduce processor temperatures.

A model for predicting heat transfer during condensation of refrigerant R134a in horizontal microchannels is presented. The thermal amplification technique is used to measure condensation heat transfer coefficients accurately over small increments of refrigerant quality across the vapor-liquid dome (0<x<1). A combination of a high flow rate closed loop primary coolant and a low flow rate open loop secondary coolant ensures the accurate measurement of the small heat duties in these microchannels and the deduction of condensation heat transfer coefficients from measured UA values. Measurements were conducted for three circular microchannels (0.506<Dh<1.524mm) over the mass flux range 150<G<750kg∕m2s. Results from previous work by the authors on condensation flow mechanisms in microchannel geometries were used to interpret the results based on the applicable flow regimes. The heat transfer model is based on the approach originally developed by Traviss, D. P., Rohsenow, W. M., and Baron, A. B., 1973, “Forced-Convection Condensation Inside Tubes: A Heat Transfer Equation For Condenser Design,” ASHRAE Trans., 79(1), pp. 157–165 and Moser, K. W., Webb, R. L., and Na, B., 1998, “A New Equivalent Reynolds Number Model for Condensation in Smooth Tubes,” ASME, J. Heat Transfer, 120(2), pp. 410–417. The multiple-flow-regime model of Garimella, S., Agarwal, A., and Killion, J. D., 2005, “Condensation Pressure Drop in Circular Microchannels,” Heat Transfer Eng., 26(3), pp. 1–8 for predicting condensation pressure drops in microchannels is used to predict the pertinent interfacial shear stresses required in this heat transfer model. The resulting heat transfer model predicts 86% of the data within ±20%.

<div class="htmlview paragraph">The electrification of accessories using a fuel cell as an auxiliary power unit reduces the load on the engine and provides opportunities to increase propulsion performance or reduce engine displacement. The SunLine™ Class 8 tractor electric accessory integration project is a United States Army National Automotive Center (NAC™) initiative in partnership with Cummins Inc., Dynetek™ Industries Ltd., General Dynamics C4 Systems, Acumentrics™ Corporation, Michelin North America, Engineered Machine Products (EMP™), Peterbilt™ Motors Company, Modine™ Manufacturing and Masterflux™. Southwest Research Institute is the technical integration contractor to SunLine™ Services Group.</div> <div class="htmlview paragraph">In this paper the SunLine™ tractor electric Air Conditioning (AC) system is described and the installation of components on the tractor is illustrated. The AC system has been designed to retrofit into an existing automotive system and every effort was made to maintain OEM components whenever modifications were made. Hardware modifications were limited to replacing the engine driven compressor for a 42 volt DC driven one, exchanging the expansion orifice for a thermal expansion valve and positioning the components to minimize the length of refrigerant lines.</div> <div class="htmlview paragraph">The thermodynamics and PID control algorithms are discussed. Closed loop test results are presented in controlled ambient conditions. Analysis of reversed Carnot cycle changes due to transient operation and coefficient of performance changes are given.</div>

<div class="htmlview paragraph">An experimental study to determine the impact of turbocharger outlet conditions, namely boost pressure and temperature, on charge air cooler durability was conducted. A charge air cooler, locally instrumented with strain gauges and thermocouples, was installed in a vehicle and tested in a controlled wind tunnel environment at conditions which produced different amounts of peak boost pressure and turbocharger outlet temperature. Findings suggest that elevated turbocharger outlet conditions should be approached with caution and that charge air coolers for such applications should include appropriate design features.</div>

<div class="htmlview paragraph">Selection of a water or air cooling medium for engine systems depends on the availability of the medium, the design of the engine, and the conditions under which the system operates. This article presents a number of cases for both water and air cooled systems, compares their characteristics, and describes the design approach toward each.</div>