- Research Article
- 10.1016/j.tjpad.2026.100519
Memory Consolidation and ARIA in Individuals Receiving Anti-amyloid Monoclonal Antibodies.
- May 01, 2026
- The journal of prevention of Alzheimer's disease
- Marc W Haut + 13 more +13
Publications from 2021 to 2026
Showing 10 of 676 papers
Memory Consolidation and ARIA in Individuals Receiving Anti-amyloid Monoclonal Antibodies.
Hybrid Temporal Modeling and Generative Augmentation for Imbalanced Multivariate Time Series Anomaly Detection in Engineering Systems
Abstract Multivariate time series (MTS) data are central to engineering systems, where streams of sensor signals enable trend analysis, anomaly detection, and the discovery of operating patterns—supporting predictive maintenance and quality control. Yet analyzing MTS remains challenging: faults are rare, severely imbalanced, and embedded in long contexts with overlapping modes. These challenges demand models that capture extended dependencies and focus on the most informative intervals. To address this, we design a hybrid deep-learning architecture integrating recurrent units for long-horizon dynamics, attention layers for critical time steps, and temporal convolutions for multi-scale local patterns. We propose GAT-Net (GRU–Attention–Temporal Convolutional Network), a robust end-to-end MTS anomaly detector. Because severe class imbalance remains the dominant barrier, we extend the backbone with a generative augmentation strategy, developing DA-GAT-Net (Data-Augmented GAT-Net). It uses a segment-aware conditional GAN to synthesize rare fault segments conditioned on local context and inserts them chronologically, preserving temporal continuity and cross-sensor correlations. We evaluate our frameworks on an industrial benchmark dataset. They outperform state-of-the-art baselines, with the generative extension yielding the largest gains in recall and F1-score. We also show that sensitivity rises sharply with a moderate amount of synthetic anomalies but levels off beyond a balanced ratio, underscoring the need for controlled, structure-preserving generation. Overall, this study highlights how attention-guided temporal modeling combined with generative augmentation can enhance fault detection in engineering systems where missed anomalies carry high operational costs.
Read morePARENTAL ADHERENCE OF ICS USE IN ASTHMA DESPITE RISK OF HEIGHT REDUCTION
1298-P: Demographic, Racial, and Regional Trends of Diabetes-Related Ischemic Heart Disease Mortality in the United States:1999–2020
Introduction and Objective: Diabetes (DM) is an independent risk factor for ischemic heart disease (IHD). We aim to investigate disparities in diabetes-related ischemic heart disease (DRIHD) mortality trends within specific epidemiological groups. Methods: We extracted data from the CDC WONDER database from 1999 to 2020.IHD was listed as the main cause of death (ICD codes: I20-I25), while DM as a contributory cause (ICD codes: E10 -E14). We calculated the Age-Adjusted Mortality rate (AAMR) per 100,000 people and annual percentage change using Joinpoint regression. Results: About 1,094,046 Individuals with DM died of IHD from 1999-2020. The overall AAMR was 14.8. Males, non-Hispanic Blacks, individuals aged 75-84 years, and people who lived in Rural areas had significantly higher AAMR. AAMRs among census regions were comparable. The AAMR of the entire cohort declined from 20.2 to 13.6 over the study period (Average Annual Percentage Change (AAPC): -2.06; 95% CI: -2.34% to -1.90). Higher AAPCs were also observed in females and people living in urban areas. Conclusion: Although DM-related IHD mortality has declined over the past 2 decades, disparities persist among Males, non-Hispanic blacks, rural dwellers, and individuals aged 75-84 years. These findings underscore the need for longitudinal studies to explore the drivers of disparities and targeted public health interventions. Disclosure E. Okorigba: None. P.A. Kwaah: None. S.A. Mensah: None. E.A. Agyemang: None. A.K. Carboo: None. G. Appah: None. H. Rashid: None.
Read moreIntersectional Embodiment: An Exploration of Women's Bodily Experiences in Contemporary American Literature
My dissertation, “Intersectional Embodiment: An Exploration of Women’s Bodily Experiences in Contemporary American Literature,” examines contemporary American novels written by women of color in order to illuminate how women of color protagonists realize, protect, and embrace their bodies as a source of power in a deeply oppressive society. Specifically, I analyze Kindred (1979) and the Parable novels (1993, 1998) by Octavia Butler, Displacement (2019), a graphic novel by Kiku Hughes, and Severance (2018) by Ling Ma. In these novels, women protagonists must account for their bodies to understand their identity, combat oppressive bodily control, and, above all, survive. Both neo-historical novels and climate fiction show how the history of the present and the future is being [re]written on the bodies of women of color. These novels rewrite the past and envision different futures, underscoring women’s struggles and their resistance to a white supremacist capitalist patriarchy. These authors confront politically divisive and culturally urgent matters: whether their characters are fleeing to safety in a climate-affected world or are actively working to free themselves from enslavement, the narrative structure of each novel reflects a specific intersectional embodied experience, one that is both racialized and gendered. Ultimately, my research highlights individual and collective histories, emphasizing that embodiment, when implicated in stories steeped in trauma, becomes formed through the racialized and gendered aspects of societal subjugation via social hierarchies. In these works, the bodies of women are infused with experience, encapsulating conglomerations of histories and harboring sites of punishment—and yet, these women fight, resist, and survive as a means to sustain autonomy and protect others.
Read moreBargaining for Statehood: The Intersection of Capitalism and Politics in the Creation of West Virginia
This project explores the original architecture of West Virginia. The plans and deliberate construction of the new state not only represented the longstanding desire of western counties for equitable representation in its legislature but also rested on the economic and political ambition of the movement’s leaders. Not all western counties supported independent statehood, and a substantial number of counties favored secession. Without a cohesive citizen consensus to embark upon statehood, traditional narratives that the western counties embarked on statehood solely to protect republican interests bears further investigation. Lacking a unified front, political and business leaders steered the movement through the intersection of capitalism and politics to create a state which, from its beginnings, was crafted to protect a specific set of interests. The new state not only served western ambitions, but it also protected the interests of a federal government that struggled to maintain loyalty across border states. The bargain for statehood at the intersection of regional capitalism and national politics served the men who led the movement. Multiple statehood leaders attained economic wealth during the process, others obtained lasting political appointments, and many obtained both. The bargain also served the Union, securing an important border state and crafting a model of rewarding loyalty.
Read moreNo Sweeter Sound: Musicking, Transformative Pedagogy, and Collaborative Social Justice in Choral Settings
Choral music and its conductors occupy a tenuous space in the 21st century. In a new cultural atmosphere influenced by Gen Z’s expectation of welcomed diversity and intolerance for injustice, TikTok’s rapid global dissemination of information and entertainment, and society’s desire for authentic connection following the Covid-19 pandemic, the dichotomies present in choral music are no longer being glossed over. Difficult conversations about race, gender, ableism, social location, and other intersectional identifiers are at the forefront of academic writing and conference presentations. Evidence of transformative pedagogy and culturally responsive practices are beginning to appear in classroom syllabi and rehearsal techniques in choral settings. The practice of collaborative social justice through choral musicking is becoming an accepted and successful model in schools, communities, prisons, rehabilitation centers, and many other places where individuals gather and become a collective. For many choral music educators, however, there is a sense of overwhelm with engagement related to social justice based concepts or subject matter and a lack of familiarity with the work of applied ethnomusicologists in music education. This creates a hesitancy that is easily supported by the trope that making music is not political. Inspiring change and equity in the communities around us through choral musicking is dependent on the encouragement of choral music educators to practice informed engagement with eventful programming, social and emotional learning, and understanding the functionalities of social justice in choral settings. My research will define transformative pedagogy, discuss the practice of musicking, and examine various concepts with their roots in social justice and applied ethnomusicology. I will offer two case studies at the collegiate level for consideration of different applications of similar methodology. The result of each is collaborative social justice through choral musicking and transformative pedagogy. The term transformative pedagogy refers to both the action of the conductor to renovate their approach to choral music education and performance, and to the transforming experience for ensemble and audience members involved in the process. My practice of looking at the choral rehearsal and performance process as musicking is further informed by my understanding of decentering, decolonizing, anti-racism, and culturally relevant teaching. The methodology of the case studies selected aim to illustrate attainable means of bringing this practice of social justice engagement to choral music educators. By discussing concepts of decentering, collaborative social justice, social and emotional learning, and transformative pedagogy, this document offers knowledge I hope others can turn into
Read moreMultifaceted Life Skills Training and Job-Orientation Supports For Individuals in Vocational Rehabilitation Programming
There is growing support for those with an intellectual or developmental disability (IDD) in the transition process and within the workplace, however, there are areas that need to be addressed to facilitate further inclusion and success in this domain. There are structured institutions within the community that extend support for those transitioning out of high school, focusing on aligning with life training and professional skills while promoting societal integration by delivering services directly and avoiding isolation within traditional service environments (Accardo & Whitman, 2011). Growing research highlights the necessity of providing resources that support individuals with intellectual and developmental disabilities in achieving independent living and community integration (Mann & Wang, 2021). Quantitative and qualitative data were collected across the 14-week capstone, primarily before and following the eight-week daily living skills program to a) assess participants’ insight into daily occupations, b) change in self-perception following the tailored program, c) an insight into barriers surrounding computer-based learning modules for new hires. It was determined that a significant change in both self-perception of functional abilities and accommodating readability of learning material was established due to the addition of occupational therapy in the transition towards vocation. The outcomes of this research have provided insight into the effects and importance of incorporating principles of occupation therapy into non-traditional entities to facilitate the vocational and functional outcomes of those involved.
Read moreGender-related Outcome Differences In Patients With Transthyretin Amyloidosis (attr): Analysis From The National Inpatient Sample (nis)
Assessing the Feasibility of the Virtual Reality Training Protocol for Sport
Research has supported the use of virtual reality (VR) in sport to train skills such as decision-making and anticipation, as well as aid in injury rehabilitation. Despite this, VR is not commonly used as a training tool in sport. Barriers to its adoption include a lack of understanding, low awareness, and risk of cybersickness. As such, there is a critical need to address these barriers and promote acceptance of VR in sport. The purpose of this single-arm, non-randomized, mixed-methods feasibility trial was to examine the feasibility and acceptability of the Virtual Reality Training Protocol for Sport (VRTPS), which was designed to address barriers to VR use in sport. We assessed pre- and post-training attitudes toward VR using the Attitudes toward Virtual Reality Technology Scale (AVRTS), which uses the Technology Acceptance Model (TAM) as a guiding framework. Participants (n = 18) completed the VRTPS, which included stages of education, acclimation, and application. Exit interviews provided further insights into participant experiences. Results from quantitative and reflexive content analyses demonstrated feasibility of the VRTPS based on recruitment and adherence, acceptability, demand, implementation, and practicality. Descriptive statistics from the AVRTS revealed pre- to post-training increases in overall attitudes toward VR, enjoyment, perceived usefulness, and ease of use, and minimal cybersickness was reported. Our findings demonstrate the feasibility and acceptability of the VRTPS and show promise for its future research and application.
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