Nagoya Bunri University

Objective:To examine associations of Dietary Inflammatory Index (DII) scores with disability and subjective health, which is prognostic of disability, in a large, systematically sampled population of older adults living in non-urban areas in Japan.Design:Cross-sectional. The Tokyo Metropolitan Institute of Gerontology Index of Competence was used to assess disability. Both overall disability and disabilities in components of everyday competence (instrumental activities of daily living (IADL), intellectual activities and social participation) were examined. Participants who reported an inability to perform one or more activities were categorised as disabled. Subjective health was assessed based on the response to the following question: ‘In general, how do you feel about your own health?’Setting:Six non-urban municipalities in Japan that differ in terms of regional characteristics.Participants:Adults aged 65–74 years (n 7930).Results:DII scores were positively associated with the odds of overall disability (OR (95 % CI)) = 1·23 (1·19, 1·28)); disabilities in IADL (OR (95 % CI) = 1·10 (1·05, 1·15)); intellectual activities (OR (95 % CI) = 1·28 (1·23, 1·33)); social participation (OR (95 % CI) = 1·17 (1·13, 1·22)) and poor subjective health (OR (95 %CI) = 1·09 (1·05, 1·14)).Conclusions:Our results imply the importance of reducing dietary inflammation to prevent both disability and a decline in subjective health, a predictor of disability.

Background and Objectives: In geriatrics and dementia care, early diagnosis is crucial. We developed a dementia screening model using drawing features from clock drawing tests (CDT) and investigated the features contributing to the discrimination of dementia and its screening performance. Methods: This study included 129 older adults attending a dementia outpatient clinic. We obtained information on the diagnosis of dementia and CDT data from medical records and quantified 12 types of drawing features according to the Freedman scoring system. Based on the dementia diagnosis information, participants were assigned to two groups: 58 in the dementia diagnosis group and 71 in the non-diagnosis group. Using Boruta, an iterative feature selection algorithm, and a support vector machine, a machine learning method, we analyzed the drawing features contributing to dementia discrimination and evaluated discrimination performance. Results: Five types of drawing features were selected as contributors to discrimination, including “numbers in the correct position,” “minute target number indicated,” and “hand in correct proportion.” These features exhibited a discriminating sensitivity of 0.74 ± 0.16 and specificity of 0.74 ± 0.18 for detecting dementia. Conclusion: This study demonstrated a method for identifying individuals likely to be diagnosed with dementia among patients attending a dementia outpatient clinic using drawing features. The knowledge of drawing features contributing to dementia differentiation may assist healthcare practitioners in clinical reasoning and provide novel insights for clinical practice. In the future, we plan to develop a primary screening for dementia based on machine learning using CDT.

Background/AimsNutritional factors associated with gastric cancer (GC) are not completely understood. We aimed to determine the effect of nutrient intake on the incidence of GC.MethodsThis was a post hoc analysis of a prospective trial that evaluated modalities for GC screening in participants aged 30 to 74 years living in high-risk areas for GC in Japan between June 2011 and March 2013. The patients were followed up for GC incidence for 6 years. All participants completed a self-administered food frequency questionnaire (FFQ) upon enrollment before GC screening. Daily nutrient intake was calculated from the FFQ and dichotomized at each cutoff value using receiver operating characteristic analysis. Risk factors associated with GC incidence were investigated in terms of nutrient intake and participant characteristics using Cox proportional hazards regression analysis.ResultsOverall, 1,147 participants were included in this analysis. The median age was 62 years, and 50.7% of the participants were men. The median follow-up period was 2,184 days. GC was detected in 25 participants during the follow-up. Multivariate Cox proportional hazards regression analysis revealed that the intake of sodium (adjusted hazards ratio [aHR], 3.905; 95% confidence interval [CI], 1.520 to 10.035; p=0.005) and vitamin D (aHR, 2.747; 95% CI, 1.111 to 6.788, p=0.029) were positively associated with GC incidence, whereas the intake of soluble dietary fiber (aHR, 0.104; 95% CI, 0.012 to 0.905; p=0.040) was inversely associated with GC incidence.ConclusionsDaily high intake of sodium and vitamin D and low soluble dietary fiber intake are associated with GC incidence. (Gut Liver, Published online February 23, 2024)

From the biota beneath the sea ice in Lake Saroma, which is adjacent to Sea of Okhotsk, a diatom culture of Saroma 16 was isolated. Strutted processes and a labiate process in Saroma 16 were characteristic of those in Thalassiosira nordenskioeldii. Similarity search analysis showed that the 826-bp rbcL-3P region sequence of this strain was 100% identical to multiple sequences registered as T. nordenskioeldii in a public database. The 4305-bp PCR-amplified mitochondrial cytochrome c oxidase subunit I (COI) gene (COI)-5P region of Saroma 16 included a 1060-bp open reading frame (ORF), which was interrupted by 934-bp and 2311-bp introns that included frame-shifted ORFs encoding reverse-transcriptase (RTase)-like proteins. Previous reports showed that a strain of the same species, CNS00052, originating from the East China Sea included no introns in the COI, whereas North Atlantic Ocean strains of the same species, such as CCMP992, CCMP993, and CCMP997, included a 2.3-kb intron in the same position as Saroma 16.

Background: Food deserts (FDs) can be one cause of poor food consumption and nutritional deficiency among older people. Nagasaki City consists of different unique living environments, such as hillside sloped areas, isolated islands and central urban areas. In addition, aging and depopulation in Nagasaki City are progressing. This study aimed to reveal the relationships between shopping behaviors and the neighborhood food environment and dietary intakes among middle-aged and older people living in Nagasaki City.

Objective:Healthy dietary patterns have been linked to lower levels of chronic inflammation. The present study aimed to investigate the associations between food group intakes and high-sensitivity C-reactive protein (hsCRP) among community-dwelling adults.Design:Cross-sectional.Setting:Three areas in Japan (Shiga, Fukuoka, or Kyushu and Okinawa).Participants:The present analysis included 13 648 participants (5126 males and 8522 females; age range, 35–69 years) who had been enrolled in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Food group intakes were estimated using a FFQ. Multiple linear regression was used to examine associations between the quartiles of each energy-adjusted food group intake and log-transformed hsCRP.Results:The following concentration ratios of hsCRP after comparing the highest and lowest quartiles of food group intake were significant: in males, 1·12 (95 % CI 1·02, 1·22) for processed meat, 1·13 (95 % CI 1·03, 1·24) for fish and 0·83 (95 % CI 0·76, 0·90) for nuts; in females, 0·89 (95 % CI 0·81, 0·97) for bread, 1·11 (95 % CI 1·03, 1·19) for processed meat, 0·86 (95 % CI 0·80, 0·92) for vegetables, 1·19 (95 % CI 1·11, 1·29) for fruit, 0·90 (95 % CI 0·84, 0·97) for nuts and 0·88 (95 % CI 0·82, 0·95) for green tea.Conclusions:Processed meat and nut intakes were associated with higher and lower hsCRP levels, respectively, in both sexes. However, for several food groups, including fish and fruit, previous findings from dietary pattern analyses were not supported by the present analyses at the food group level.

【目的】油脂の品質評価は,操作が煩雑な複数の分析法によって総合的に行われるため,多くの時間と労力を必要とする.また,分析では多量の有機溶媒を使用するため,環境への影響や分析者への慢性的な健康被害も懸念される. そこで本研究では,多量の有機溶媒を使用することなく,複数の蛍光物質を含む試料の蛍光スペクトルを網羅的に,かつ簡便に測定できる蛍光指紋法を用いた油脂の品質評価法について検討を行った.

Introduction: Chewing well is linked to preventing obesity and lowering the risk of type-2 diabetes and the importance of mastication is recognized. In the field of dentistry, there have been numerous reports on the relationship between bite and tolerance to exercise. However due to the lack of reports relating to mastication and tolerance to exercise we aim to clarify the relationship between mastication and tolerance to exercise and bone density.