National University of Quilmes

Background and Objectives: We aimed to describe early real-world visual, refractive, and safety outcomes following implantation of a novel hybrid full range of vision intraocular lens (IOL) in patients undergoing cataract surgery. Materials and Methods: This prospective, single-center, non-randomized clinical study included 50 patients (100 eyes) undergoing bilateral sequential cataract surgery with implantation of the Max Vision™ IOL. Uncorrected and corrected distance visual acuity (UDVA, CDVA) and uncorrected near visual acuity (UNVA) at 32 cm and 40 cm were assessed using logarithmic charts. Spherical equivalent (SE) refraction, intraocular pressure (IOP), and safety outcomes were recorded preoperatively and at postoperative day 1, week 1, and month 1. Preoperative and postoperative values were compared statistically. Results: The mean age was 66.1 ± 7.9 years. At 1 month, mean UDVA improved from 0.58 ± 0.24 to 0.01 ± 0.03 logMAR, and mean CDVA from 0.18 ± 0.20 to -0.001 ± 0.01 logMAR (both p < 0.001). Mean UNVA improved from 0.64 ± 0.18 to 0.19 ± 0.10 logMAR at 32 cm and from 0.61 ± 0.15 to 0.13 ± 0.11 logMAR at 40 cm (both p < 0.001). Mean SE changed from 1.16 ± 1.7 D preoperatively to 0.04 ± 0.4 D at 1 month (p < 0.001). Mean IOP showed a transient increase on postoperative day 1 followed by a reduction at 1 month, without the need for additional hypotensive therapy. No eyes lost two or more lines of CDVA. One posterior capsular rupture occurred without postoperative sequelae. Conclusions: At 1 month after cataract surgery, implantation of the Max Vision™ IOL was associated with improved distance and near visual acuity, early refractive accuracy, and no major short-term safety concerns, under routine clinical conditions.

Background: Fetuin (Ft) is the most abundant protein in fetal bovine serum (FBS) and is considered one of its essential components. This acidic glycoprotein plays a key role in cell adhesion and proliferation and is vital for maintaining in vitro cultures of animal and human cells, tissues, and organs. FBS is a natural source for Ft purification. However, the high demand for FBS as a standard reagent in cell culture severely limits its availability for use as a raw material for protein purification. Furthermore, the industrial production of FBS results in a significant amount of contaminated FBS. This contaminated fraction can thus be utilized for Ft recovery. Methods: In this work, we present a novel method for Ft recovery from FBS using a single chromatographic step based on anion exchange chromatography under acidic conditions. Results: Optimal adsorption conditions for Ft were studied using response surface methodology (RSM), which suggested a buffer pH of 4.2 and an FBS dilution of 40%. However, increasing the pH to 5 resulted in a 28% increase in Ft recovery, although with a slight reduction in Ft purity to 88%. A scale-up to half a liter of FBS was performed using a 400 mL column. A single-step elution with 0.3 M NaCl was employed, yielding an Ft recovery of 90% with a purity greater than 82%. Conclusions: The purified Ft demonstrated biological activity as a growth promoter in MDBK cell culture when utilized in a serum-free culture medium.

Abstract The ideas about the origins and role of motor variability have been revised in recent years after realizing that a strictly peripheral origin is not sufficient to explain many observed aspects of brain function. Among these, time processing is emerging as one of the least studied functions where motor variability might have a critical role. Time processing in the range of hundreds of milliseconds includes the phenomenon of sensorimotor synchronization (SMS), where both sensory and motor timing processes play in parallel, likely overlapping in time. The most common and simple task to study SMS is paced finger tapping, where a person taps in synchrony with a periodic sequence of brief stimuli as in keeping pace with music. The main observable is the asynchrony, that is the time difference between every response and the corresponding stimulus along the sequence. Here we report that the variability of asynchronies in a paced finger-tapping experiment ($N=44$) is correlated with the variability of the tapping force such that participants with smaller force variability have a better timing precision---but only in the absence of auditory feedback from the taps. We explain our observation by describing a potential mechanism based on empirical and theoretical results that bridges the gap between timing variability and force variability. Our results suggest that the tactile feedback in the presence of auditory feedback is mostly irrelevant in the perceptual determination of the occurrence time of the tap.

Este estudio examina las tensiones socioambientales que atraviesan el partido de Luján (Buenos Aires, Argentina), enfocándose en las relaciones entre urbanización, patrimonio natural y dinámicas climáticas. A través del estudio de las inundaciones recurrentes y la ocupación de humedales, se examinan los impactos territoriales y socioambientales de un modelo de desarrollo urbano que ha incrementado la vulnerabilidad ante eventos hidrometeorológicos extremos. Frente a ello, las comunidades locales han activado procesos de patrimonialización del entorno natural, resignificando los humedales como defensas naturales, paisajes culturales y territorios comunes en disputa. El enfoque metodológico combina historia ambiental, ecología política y análisis crítico del discurso para comprender cómo se construyen sentidos alternativos sobre el territorio desde abajo, promoviendo prácticas de resiliencia comunitaria.

Este escrito intenta reconstruir la preocupación de Enrique Dussel por afirmar y desarrollar filosóficamente un proyecto transmoderno que aspire a promover la alteridad cultural de los pueblos poscoloniales a partir de los aportes de la Filosofía de la Liberación. En primer lugar, se busca reconstruir los inicios de las preocupaciones del filósofo por la problemática de las culturas y sus relaciones entre sí, tomando como punto de partida algunos escritos biográficos del propio autor y las influencias teóricas que le permitieron la construcción de la Filosofía de la Liberación, lo que devendrá, en textos posteriores, en la propuesta de una filosofía transmoderna. En segundo lugar, se presentan algunas reflexiones en torno a la figura del pueblo oprimido como sujeto privilegiado de la liberación y del diálogo intercultural que constituirá el proyecto transmoderno. Finalmente, el texto analiza a la Transmodernidad y a sus notas características en relación a la consideración de la Modernidad como una invención y a la apuesta por un “pluriverso trans-moderno (con muchas universalidades), multicultural, en diálogo crítico intercultural” (Dussel, 2015, p. 257)

Este artículo analiza cómo las expectativas y proyecciones de futuro inciden en los procesos de innovación tecnológica, tomando como caso de estudio el desarrollo y uso de bioinsumos en Argentina. A partir del enfoque metodológico del análisis causal por capas propuesto por Inayatullah (1998), se examinan los discursos estatales, mediáticos y técnicos que configuran los imaginarios sociotécnicos en torno a esta tecnología emergente. El estudio se basa en el análisis del Plan de Acción para el sector de bioinsumos elaborado por el Ministerio de Agricultura, Ganadería y Pesca de la Nación Argentina, entrevistas a profesionales del área y un relevamiento de noticias especializadas. El trabajo identifica tres imaginarios predominantes —mercantil, desarrollista y de justicia socioambiental— que operan como promesas tecnológicas con capacidad performativa, orientando políticas públicas, prácticas productivas y trayectorias científicas. Se argumenta que estas representaciones del futuro no solo legitiman decisiones presentes, sino que contribuyen activamente a su configuración. En este sentido, los bioinsumos se presentan como una alternativa estratégica frente al modelo agroquímico dominante, con potencial para fortalecer la autonomía tecnológica, la soberanía alimentaria y la inserción internacional de Argentina en el sistema-mundo.

En este trabajo se analiza, desde una mirada del Sur Global el lugar que ocupa la Ciencia y la Tecnología en el mundo actual, teniendo en cuenta la evolución del sistema capitalista desde mediados del siglo XX hasta la actualidad. El artículo desarrolla brevemente el concepto de Norte y Sur global y discute los desafíos que en materia de políticas científico-tecnológicas se le presentan a los países del Sur global, así como las distintas estrategias que algunos de estos países han utilizado y que podrían replicarse en otros.

Abstract We introduce the ${{\mathcal L}_!^{\mathcal S}}$-calculus, a linear lambda-calculus extended with scalar multiplication and term addition, that acts as a proof language for intuitionistic linear logic. These algebraic operations enable the direct expression of linearity at the syntactic level, a property not typically available in standard proof-term calculi. Building upon previous work, we develop the ${{\mathcal L}_{!}^{\mathcal S}}$-calculus as an extension of the ${\mathcal L}^{\mathcal S}$-calculus with the ! modality. We prove key meta-theoretical properties—subject reduction, confluence, strong normalization and an introduction property—as well as preserve the expressiveness of the original ${\mathcal L}^{\mathcal S}$-calculus, including the encoding of vectors and matrices, and the correspondence between proof-terms and linear functions. A denotational semantics is provided in the framework of linear categories with biproducts, ensuring a sound and adequate interpretation of the calculus. This work is part of a broader programme aiming to build a measurement-free quantum programming language grounded in linear logic.