NetDragon (United States)

Small and large deformation behaviour of back fat from pork/beef/lamb was dominated by the fat phase at room temperature and by the protein network at higher temperature. Our insights help to replicate fat functionality using plant-based materials.

ABSTRACT COVID-19 has had a profound influence on the conduct of teaching and learning in higher education. Almost everywhere a sudden shift occurred as educators transitioned courses from mainly face-to-face teaching and learning to emergency remote instruction, mostly conducted online. While details varied for individual faculty members, institutions, and countries, all confronted new challenges. We examine the immediate effects of COVID-19 on teaching and learning in higher education. Our results are based on a sample of 309 courses, and the academic staff who taught them, at eight colleges and universities varying in size and context across four continents. We document first how institutions, and their instructors, varied in their capacity for dealing with the rapidity of the COVID-19 teaching and learning pivot. We further demonstrate that the suddenness of the pandemic’s onset, and the quick response this demanded of instructors, meant that there was little systematic patterning in how academic staff were able to adapt – save for nimbleness. Rapidity of response meant differences were far more idiosyncratic than they were systematic, at least with respect to how individual faculty responded.

The ketone intermediate LSN647712 is a key synthetic intermediate for the drug substance lasmiditan manufacturing process. A three-step connected continuous flow process utilizing a Turbo Grignard reagent, N-methylpiperidin-4-ylmagnesium chloride, and lithiated 2,6-dibromopyridine sequentially added to double electrophile (O═C(++) synthon dimethylcarbamyl chloride (DMCC) was developed to deliver the ketone intermediate in a high chemical yield (>85%). This highly productive (>100 g/h lab system) and intensified process (τ ∼ 3 min) yields the product in high purity upon batch reactive crystallization to form a corresponding hydrobromide salt. In addition to the connected plug flow reactor system, the Grignard reagent, N-methylpiperidin-4-ylmagnesium chloride, was also prepared continuously in CSTR as a more soluble LiCl adduct in THF (Turbo Grignard).

In this article, we describe the process development efforts to improve the final methylation step in the AMG 397 drug substance process, culminating in the execution of a Good Manufacturing Practi...

PICO question
 In transfusion-naïve cats receiving a type specific blood transfusion is cross-matched blood (major and minor) associated with an increased haematocrit development and reduction in acute transfusion reactions when compared with those receiving non-crossmatched blood?
 
 Clinical bottom line
 Category of research question 
 Treatment
 The number and type of study designs reviewed
 Ten papers were critically reviewed. There were four retrospective case series, three prospective cross-sectional surveys, a retrospective cohort study, a prospective case series and a prospective randomised control trial.
 Strength of evidence 
 Weak
 Outcomes reported
 It would appear that in the United Kingdom the incidence of non-AB transfusion reactions is low. A single study suggests that cross-matching may result in a greater improvement in haematocrit, but this is unlikely to be clinically significant. There is evidence to support the hypothesis that non-AB antigens (for example the Mik antigen) differ with geographic distribution.
 Conclusion
 Based on the information available it is it is challenging to establish a meaningful clinical conclusion on which to base a recommendation.
 
 How to apply this evidence in practice
 The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
 Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
 

The chalcogenide compound CuNbGaSe3, belonging to the system I-II-III-VI3, has been investigated by means of X-ray powder diffraction and its crystal structure has been refined by the Rietveld method.This is a material of the semiconductor type, which improves the properties of a simple semiconductor like CuGaSe2 because it ads spintronic applications due to its magnetic behavior. The powder pattern was composed by 94.2% of the principal phase CuNbGaSe3 and 5.8% of the secondary phase Cu0.667NbSe2. This material crystallizes with a CuFeInSe3-type structure in the tetragonal space group P4 2c (Nº 112), unit cell parameters a = 5.6199(4) Å, c = 11.0275(2) Å, V = 348.28(4) Å3, with a normal adamantane-structure where occurs a degradation of symmetry from the chalcopyrite structure I4 2d to a related structure P4 2c.

Abstract The development of a flow chemistry process for asymmetric propargylation using allene gas as a reagent is reported. The connected continuous process of allene dissolution, lithiation, Li‐Zn transmetallation, and asymmetric propargylation provides homopropargyl β‐amino alcohol 1 with high regio‐ and diastereoselectivity in high yield. This flow process enables practical use of an unstable allenyllithium intermediate. The process uses the commercially available and recyclable (1S,2R)‐N‐pyrrolidinyl norephedrine as a ligand to promote the highly diastereoselective (32:1) propargylation. Judicious selection of mixers based on the chemistry requirement and real‐time monitoring of the process using process analytical technology (PAT) enabled stable and scalable flow chemistry runs.

Understanding ‘picky eaters’ will help practitioners get children eating healthily, says Mary Llewellin

A novel synchronizing technique is applied to a ring bus configured power system, with multiple solid-state inverters, to allow the bus-tie breaker to be closed at any time. After paralleling, load sharing is magnetically controlled without electronic circuitry or software control. Compared to the traditional one-at-a-time synchronization process, this approach significantly shortens the synchronization time as well as the interconnect-signal wire length, thus improving reliability and lowering the cost. This paper discusses the principles of this synchronization and load share control technique, supported by test results.

This paper describes operation and application of SABT in mission-critical applications on board navy ships. Typically, static automatic bus transfer switches (SABT) use silicon-controlled rectifier (SCR) power-switching elements to transfer critical loads from a primary power source to an alternate power source in the event of interruption or abnormal conditions. Since switching occurs in less than four milliseconds (4/1000th of a second), infinitely faster than electromechanical switches, it appears seamless to even the most sophisticated weapon systems. SABT facilitate maintenance by incorporating modular construction down to the LRU level. Self-diagnostic testing and remote monitoring and control features are included. Over 500 SABT successfully installed on US Navy destroyers, submarines and aircraft carriers. The paper also describes the novel solid state dual-function switch (DFS) that acts as a solid-state auto-bus transfer switch (SABT) or as a solid-state current interrupter (SSCI), depending upon whether a source fault or a load fault detected. Various types of semiconductors (thyristor, IGBT, and MCT) were compared. This combined function further reduces the cost, dimensions, and weight of the power system.