Nizhnevartovsk State University

Programming is a labor-intensive process that requires developers to undergo years of training and constant practice in coding. Therefore, in the search for ways to simplify the process of developing software algorithms, technologies such as No-Code and Low-Code for block assembly of applications have been developed. The use of Low-Code solutions significantly accelerates software development by minimizing manual programming effort. The 1C:Enterprise 8.3 platform serves as a vivid example of such a tool, providing an extensive range of ready-made solutions and components that simplify the configuration and implementation of business applications. The article examines the main features of the 1C:Enterprise 8.3 system as a Low-Code platform for creating business applications and describes its potential use in universities. The study is based on general scientific methods, analysis and synthesis of scientific and specialized literature, and a comparative analysis of Low-Code technologies for developing business applications with other. The study’s results are presented through an analytical review of the 1C:Enterprise 8.3 platform solutions used in the educational process for students in technical fields. The practical significance of the results obtained confirms the feasibility of using the 1C:Enterprise 8.3 platform in the educational process as an effective Low-Code tool for creating business applications, allowing you to speed up the development process and implement innovative ideas.

Subject of research: optimization through mathematical modeling and the development of a software product for selecting the techno-economic parameters of an installation designed for the integrated extraction of hydromineral raw materials from produced water of oil and gas fields. Purpose of research: to develop a methodology for selecting the optimal configuration of a hydromineral extraction installation based on simulation modeling and the analysis of profitability and risk under stochastic fluctuations of technological and market factors. Methods of research: the study employs a set of methods of systems analysis, stochastic modeling, and multicriteria optimization. The main tool is Monte Carlo simulation, which makes it possible to account for the random nature of technological and economic parameters. Efficiency is evaluated using the expected profit and its variance as a measure of risk, while rational solutions are selected according to the principles of Pareto optimality. Object of research: the techno-economic parameters of an installation for the integrated extraction of hydromineral raw materials from produced water. Research findings: a structural framework of a simulation model has been developed that enables statistical evaluation of techno-economic indicators and identification of the most efficient alternatives among multiple configurations of installations for the integrated extraction of hydromineral raw materials from produced water. It has been established that the use of multi-element extraction schemes reduces the variance of profit while maintaining profitability. The results of the study represent a preparatory stage and provide the methodological foundation for the subsequent development of a software system for optimizing the configuration of installations for the integrated extraction of hydromineral raw materials.

Background. A Russian phase IV observational study was initiated to evaluate the efficacy and safety of lenvatinib with pembrolizumab (Len-Pembro) in patients with advanced renal cell carcinoma (RCC) receiving therapy in real-world practice. This article is based on the results of the third analysis conducted with a median follow-up of 23.1 months and reflects data on the efficacy and safety of Len-Pembro in Russian patients. Aim. To evaluate the real-world efficacy and safety of Len-Pembro in patients with advanced RCC with a median follow-up increased to 23.1 months. The primary outcome of the study was progression-free survival (PFS), the secondary outcomes included overall survival (OS), progression-free survival on next-line therapy (PFS2), objective response rate (ORR), duration of response, as well as safety. Materials and methods. The study included data from 165 patients with verified advanced RCC who received Len-Pembro at 36 centers in the Russian Federation from February 05, 2018 to July 30, 2025. The median age was 60 (20–76) years, and 70.3% of the participants were male. Most patients (74.6%) presented with Karnofsky performance score of ≥80%, metachronous metastases (50.9%) of clear cell RCC (93.3%) in 1 organ (75.2%), and had not received any anticancer treatment (91.0%). The IMDC favorable prognosis group included 40 (24.2%), intermediate – 92 (55.8%), and unfavorable prognosis – 33 (20.0%) patients. The median follow-up reached 23.1 (0.5–72.9) months. A total of 110 (66.7%) patients completed Len-Pembro therapy, and 51 (30.9%) patients received next-line treatment. Results. Median PFS reached 25.8 (95% confidence interval – CI 17.0–34.5) months, 23-month PFS – 52.6%; median OS was 39.9 (95% CI 26.9–52.8) months, 23-month OS – 73.1%; median PFS2 was 33.2 (95% CI 23.4–41.1) months, 23-month PFS2 – 66.9%. The ORR was 49.1%, including 3.0% of complete responses, and the disease control rate was 89.1%. The median duration of response reached 29.7 (95% CI 24.9–34.6) months. The incidence of any adverse events (AEs) was 78.8%, severe AEs occurred in 29.1%, fatal AES – in 1.2%, immune-related AEs – 17.0%, severe immune-related AEs – 6.7%. Conclusion. In real-world practice, with increased follow-up duration, the values of PFS, OS, and PFS2 were comparable to those obtained in the registrational study, with a lower ORR and a satisfactory safety profile of the combination of Len-Pembro in advanced RCC.

The article is devoted to a comprehensive study of the formation and evolution of oratory in the context of preaching, which is viewed through the prism of homiletics - a key theological discipline that studies the principles, methods and forms of Christian preaching. Using historical and comparative, typological methods, as well as the method of theoretical generalization, the author covers a long historical period, starting from the inception of Christian teaching and ending with modern trends in preaching practices, and offers an analysis of the key stages and features of the development of homiletics as a scientific and practical discipline. Particular attention is paid to the study of the interaction of homiletics with rhetorical traditions, which play an important role in the formation and development of preaching as a genre. Starting from the complete denial of rhetoric in the first centuries of Christianity, preachers gradually come to the need to apply their knowledge and education in the preparation of homilies, combining the spiritual and rational principles in the sermon. The first to apply and implement this concept was Origen. As a result of the further development of preaching by the 4th century, two fundamental approaches to building Christian preaching were formed: prophetic and rhetorical. The prophetic tradition, based on the Old Testament model of prophetic service, is characterized by a predominance of emotional impact, direct transmission of divine revelation and the absence of complex rhetorical processing. In contrast, the rhetorical tradition emphasizes the strict structuring of the sermon, the use of oratory techniques and the logical sequence of presentation of the material according to the rules of ancient rhetoric. On the basis of an analysis of historical sources and theological works, the essence of each direction, their characteristics and complementary nature are revealed, creating an integral system of church preaching. The study is based on the works of leading experts in the field of homiletics and relies on fundamental works on the history of Christian preaching, which makes it possible to present a comprehensive vision of the problem of interaction between the prophetic and rhetorical principles in church preaching.

This article provides a comparative analysis of apocalyptic motifs in A.A. Blok's poem “The Twelve” and M.A. Bulgakov's novel “The White Guard”. The research focuses on eschatological imagery as a key tool for artistic interpretation of the revolution and the Civil War. The relevance of the work is determined by the need for a systematic study of the understanding of biblical texts in the Russian literature of the transitional era. The paper proves that, despite the commonality of the subject, the authors demonstrate fundamentally different strategies for representing the historical cataclysm. Blok's poem is interpreted as the embodiment of the idea of an irreversible end, where the symbols of world conflagration and demonic blizzard become central, and the ambivalent image of Christ in the finale emphasizes the paradoxical combination of hope for transformation and awareness of the destructive nature of revolutionary chaos. In contrast, Bulgakov's novel is viewed through the prism of a cyclical model of history, where the apocalypse is understood as a stage of necessary destruction leading to rebirth. The article pays special attention to the analysis of the dream system, which performs a prophetic function and is saturated with apocalyptic symbols, as well as the transformation of the City space under the influence of demonic forces. The methodological basis is based on comparative historical and structural-semantic approaches, which make it possible to identify the specifics of the artistic embodiment of eschatological and apocalyptic themes. The structural and semantic analysis reveals the symbolism of key images and scenes. The comparative approach allows us to identify two different ways of artistic reflection: Blok's model of the impetuous end is contrasted with Bulgakov's concept of the apocalypse as a tragic but necessary transformation, reflecting the diversity of creative responses to the historical upheavals of the early 20th century.

Childhood anemia is a major global health issue, impairing growth, cognitive development, and immune function. Its prevalence is particularly concerning in post-conflict regions where healthcare infrastructure, nutrition, and sanitation are compromised. In Mosul, Iraq, years of conflict and displacement have heightened children’s vulnerability to nutritional deficiencies and infections, yet localized epidemiological data remain scarce. Limited evidence exists on the combined biological and community health determinants of anemia in Iraqi primary school children, restricting effective intervention planning. This study aimed to determine the prevalence of anemia among school-aged children in Mosul and identify its key biological and socio-environmental determinants. Results: A cross-sectional study of 850 children aged 6–12 years revealed an overall anemia prevalence of 42.5%, with mild anemia as the most common form (65.1%). Logistic regression analysis identified low maternal education (OR = 2.34, p < 0.001), low household income (OR = 2.16, p < 0.001), infrequent red meat intake (<2 times/week, OR = 2.80, p < 0.001), stunting (OR = 3.50, p < 0.001), and a history of parasitic infection (OR = 2.10, p = 0.003) as significant predictors. This is among the first large-scale studies in Mosul to integrate both biological and community-level determinants of anemia, reflecting the multifactorial nature of the condition in post-conflict settings. The findings underscore the urgent need for multisectoral interventions, including nutritional supplementation, deworming, health education, and sanitation improvements, to combat childhood anemia and improve long-term child health outcomes in Mosul. Highlights: Childhood anemia prevalence in Mosul primary schools was 42.5%, classifying it as a severe public health problem. Key determinants included low maternal education, low household income, infrequent red meat consumption, stunting, and parasitic infections. Findings highlight the urgent need for multisectoral interventions combining nutrition, deworming, education, and sanitation improvements.

The article examines the concept of continuing education in the context of modern socio-economic changes and technological development. The main focus is on the role of continuing education in training professionals who are able to adapt to rapidly changing labor market conditions and requirements. The impact of technological progress on society and the education system is analyzed, and the main functions of continuing education are highlighted: professional, social and personal. The work emphasizes the importance of developing students' independence, responsibility and determination in the process of continuous professional education. The necessity of updating the knowledge and skills of specialists in various fields is emphasized in order to maintain competitiveness. The article considers the role of learning foreign languages in professional training and their impact on the expansion of human opportunities in education, work and communication. Theoretical research methods were used to analyze the problem, including analysis of scientific publications and official documents, such as the Concept of Technological Development of Russia until 2030. As a result of the analysis, the key competencies necessary for successful professional, family and social life in the context of the transformation of the socio-economic sphere have been identified. Among them are computer skills and foreign languages, technological literacy, entrepreneurial skills and social skills. It was also noted that Nizhnevartovsk State University (NVSU) pays special attention to the study of English in the framework of the program "English for academic mobility". It is emphasized that academic mobility contributes to the expansion of educational horizons, the formation of intercultural competencies and the creation of employment potential for graduates.

The aim of the study is to determine the main patterns of physical development (PD) of students of a northern university. The objectives included collecting data on somatic and physiometric parameters of first-year students of Nizhnevartovsk State University (young men and young women aged 17–18 years), retrospective analysis of the indicators obtained during annual examinations since 2003 (cumulative total: 1285 young women and 1065 young men). The study used standard methods for assessing the level of physical development and functional capabilities of the body. Statistical data processing was carried out using the Microsoft Excel, Statistica 10.0 software package. As a result of the analysis, the following features of PD were revealed: from 2003 to 2024, young men and young women showed an increase in somatometric indicators, such as body length and weight, which corresponds to the secular trend of increasing these parameters. Along with this, a decrease in muscle strength of the leading hand is noted in both young men and young women. A linear trend of decreasing vital capacity of the lungs is observed, correlating with the chest circumference indicators, which signals a negative trend in the decline in the functional capabilities of the respiratory system of the younger generation. A significant deterioration in strength capabilities among students in 2020 may be a consequence of a decrease in the level of physical activity during the COVID-19 pandemic. The results of the study emphasize the importance of continuous monitoring of the physical development of students and the use of comprehensive measures to maintain health and increase the physical activity of student youth.

This article presents an analytical review of scientific studies focusing on the issue of microplastic pollution in freshwater bodies in Russia. The study examines in detail the primary sources of microplastic particles entering aquatic environments, including domestic and industrial wastewater, rainwater runoff, urban dust, and diffuse sources such as the decomposition of plastic waste in landfills and natural environments. Special attention is given to the methods of collecting water and sediment samples employed by various research groups. Contemporary approaches to microplastic detection and identification are described, including visual methods using optical and electron microscopy, Fourier-transform infrared (FTIR) spectroscopy, and Raman spectroscopy. The review presents data on the impact of microplastics on biological organisms and ecosystems, including disruptions in trophic networks and impairments in the functioning of the endocrine, reproductive, and immune systems. Aspects of the mechanical and toxicological effects of microplastics are considered, as well as the processes of contaminant sorption onto their surfaces. The conclusion highlights the need for further standardization of research methodologies and additional investigations to gain a deeper understanding of the extent of microplastic distribution in freshwater ecosystems, particularly in regions with insufficient empirical data. The importance of developing comprehensive strategies to minimize microplastic pollution in freshwaters is emphasized.

Nonmelanoma malignancies associated with congenital melanocytic nevi (CMN) are extremely rare, with only 12 reported cases of rhabdomyosarcoma (RMS) to date. We present 2 additional cases of RMS arising in giant CMN, with immunohistochemical and molecular biologic investigations. The first case was a 32-year-old woman with a personal history of melanoma in giant CMN who, after successful treatment and long remission, presented with a new 1-cm nodule within the CMN. Microscopically, the atypical areas exhibited a round cell/alveolar morphology with immunoreactivity for desmin and myogenin, and lacked PAX3/7::FOXO1 fusions typical for alveolar RMS on a reverse transcription polymerase chain reaction analysis. An identical NRAS p.Q61R mutation with comparable variant allele frequency (32% and 44%) was identified in both the nevus and the RMS tissue by next-generation sequencing. The second patient was a 5-year-old girl with a rapidly growing, bleeding, ulcerated 3 × 4 cm interscapular mass within a giant CMN that histologically seemed as a proliferation of pleomorphic spindle, polygonal and epithelioid cells with marked pleomorphism immunoreactive for myogenin, muscle-specific actin, and smooth muscle actin. Next-generation sequencing yielded an HRAS p.Q61R mutation with limited variant allele frequency (7%) in the RMS component, while ATRX p.Q2193* variant was detected in the nevus. Our study is apparently the first report of NRAS and HRAS mutations in tumors with RMS phenotype arisen in CMN.