Ocná klinika

An analysis of literature data on the risk, mechanisms and methods of preventing the formation of seroma as the most common complication during abdominoplasty was conducted. The literature search was carried out from 2011 to 2024 using Pubmed, Springer, eLIBRARY websites in both Russian and English. It is assumed that the pathogenesis of seroma is based on the disruption of the integrity of lymphatic and vascular ducts, the formation of closed spaces, tissue trauma, which contributes to the release of in˜ammatory mediators. The incidence of seroma after abdominoplasty averages about 10%, although literature provides data on the level of this indicator up to 25%. Although seromas often resolve on their own, lack of treatment can lead to serious complications, such as wound edge dehiscence, infection, skin ˜ap necrosis, and pseudocyst formation. These complications signi†cantly compromise the cosmetic results of the surgery and increase the duration of hospitalization for patients. Considering that abdominoplasty is a planned operation, it is important to minimize the likelihood of seroma formation. A number of methods have been proposed to prevent seroma after abdominoplasty, including the placement of suction drains, the use of †brin glue, quilting sutures, progressive tension sutures, and the preservation of Scarpa’s fascia. The established e—ectiveness of the use of progressive tension sutures, sutures for tissue †xation, surgical glue and preservation of Scarpa’s fascia is con†rmed by data with a high level of evidence. The need for further randomized comparative prospective studies aimed at analyzing the use of various methods for preventing the occurrence of seroma after abdominoplasty is indicated.

Study DesignReliability study utilizing 183 injury CT scans by 22 spine trauma experts with assessment of radiographic features, classification of injuries and treatment recommendations.ObjectivesTo assess the reliability of the AOSpine TL Injury Classification System (TLICS) including the categories within the classification and the M1 modifier.MethodsKappa and Intraclass correlation coefficients were produced. Associations of various imaging characteristics (comminution, PLC status) and treatment recommendations were analyzed through regression analysis. Multivariable logistic regression modeling was used for making predictive algorithms.ResultsReliability of the AO Spine TLICS at differentiating A3 and A4 injuries (N = 71) (K = .466; 95% CI .458 – .474; P < .001) demonstrated moderate agreement. Similarly, the average intraclass correlation coefficient (ICC) amongst A3 and A4 injuries was excellent (ICC = .934; 95% CI .919 – .947; P < .001) and the ICC between individual measures was moderate (ICC = .403; 95% CI .351 – .461; P < .001). The overall agreement on the utilization of the M1 modifier amongst A3 and A4 injuries was fair (K = .161; 95% CI .151 – .171; P < .001). The ICC for PLC status in A3 and A4 injuries averaged across all measures was excellent (ICC = .936; 95% CI .922 – .949; P < .001). The M1 modifier suggests respondents are nearly 40% more confident that the PLC is injured amongst all injuries. The M1 modifier was employed at a higher frequency as injuries were classified higher in the classification system.ConclusionsThe reliability of surgeons differentiating between A3 and A4 injuries in the AOSpine TLICS is substantial and the utilization of the M1 modifier occurs more frequently with higher grades in the system.

Study DesignRetrospective analysis of prospectively collected data.ObjectivesTo compare decision-making between an expert panel and real-world spine surgeons in thoracolumbar burst fractures (TLBFs) without neurological deficits and analyze which factors influence surgical decision-making.MethodsThis study is a sub-analysis of a prospective observational study in TL fractures. Twenty two experts were asked to review 183 CT scans and recommend treatment for each fracture. The expert recommendation was based on radiographic review.ResultsOverall agreement between the expert panel and real-world surgeons regarding surgery was 63.2%. In 36.8% of cases, the expert panel recommended surgery that was not performed in real-world scenarios. Conversely, in cases where the expert panel recommended non-surgical treatment, only 38.6% received non-surgical treatment, while 61.4% underwent surgery. A separate analysis of A3 and A4 fractures revealed that expert panel recommended surgery for 30% of A3 injuries and 68% of A4 injuries. However, 61% of patients with both A3 and A4 fractures received surgery in the real world. Multivariate analysis demonstrated that a 1% increase in certainty of PLC injury led to a 4% increase in surgery recommendation among the expert panel, while a .2% increase in the likelihood of receiving surgery in the real world.ConclusionSurgical decision-making varied between the expert panel and real-world treating surgeons. Differences appear to be less evident in A3/A4 burst fractures making this specific group of fractures a real challenge independent of the level of expertise.

Adolescent physical changes related to hormonal changes, the period of sexual maturity and reactions to menarche. Low understanding of menarche can have a negative impact on adolescent growth. Technological progress is a potential that can be used as a delivery of material related to menarche. The "Heager" application has several features, including video features and assessment features. The purpose of this study was to determine the effect of Heager application media on the level of knowledge about menarche. This study used a pre-experimental design study with a One-Group Pre Test-Post Test Design. Data analysis used the Wilcoxon test. The results showed that the average level of knowledge about menarche before using the heager application media was 13, after using the heager application media was 15. The results of the Wilcoxon test analysis obtained a p value &lt;0.05. There is an influence of Heager application media on the level of knowledge about menarche. Most of the students who experienced an increase in knowledge were as many as 29 respondents. The conclusion of this study is that there is an effect of using Heager application media on the level of knowledge about menarche

The aim of this study was thus to assess the stress level among dental students, characterizing the factors that induce it and describing which students are most susceptible. Two international, independent and validated to polish language and environment stress questionnaires were used: the Perceived Stress Scale (PSS-10) and the Perceived Medical School Stress Instrument (PMSS). The present study received approval from the Jagiellonian University Bioethical Committee (no. 1072.6120.290.2020). A total of 272 students from all five years of the dental undergraduate degree at Jagiellonian University Medical College were enrolled to the study, including 197 female and 75 male respondents. The overall response rate was 85%. The PSS-10 score for all dental students was 22.14±6.65. A total of 182 (66.91%) respondents had high levels of stress. Female students had significantly higher stress levels than male students, accordingly 22,9±6,51 and 20,12±6,69. Moreover, first and fifth year students had the highest stress level. In the case of PMSS the total score for all dental students was 36.84±8.65. Perceived stress among Polish dental students is generally high. These findings suggest that support services should be made widely available to all dental students. Such services should be targeted to the specific needs of male and female students as well as to those in specific years of study.

Peptide-based therapies currently show an exciting renaissance of interest due to bio-technological advances, which lead to overcome peptide limitations, improving their ADME profile. Short cyclic peptides have gained a growing attention as valuable therapeutics because of their unique structures and appealing biological features such as increased bio-stability, membrane permeability, and bioavailability. It is noteworthy that peptides are the most versatile motifs offering much more functional and structural diversity than any other molecule. The function of these important biomolecules in bio-processes, and constituents of proteins, can hardly be mimicked by other chemical compounds. Thanks to recent achievements in diverse fields of science, peptides will revolutionize medicine soon, in the relation of either smart theranostics, vaccines, drug/gene delivery systems or bio-functional nanomaterials. Our project focuses on the design, synthesis, molecular and supramolecular studies on biologically active ultra-short peptides. Here, we will present results of investigation of selected cyclic tetrapeptides, that can mainly result in breakthrough in therapy of patients with organ transplants. In addition, they revealed anti-inflammatory, immunosuppressive and skin anticancer activity. Notably, lack of toxicity is observed. The special attention will be given to the survey of non-covalent intermolecular interactions, including comparative analysis with close-related representatives deposited in the structural databases, as well as peptide-mediated protein interactions. The finding can be helpful in further design of more effective innovative peptide-based therapeutics.

To evaluate the effect of crosslinking (CXL) therapy on the change in the quality of visual acuity and the change in the topographic properties of the cornea - curvature, pachymetry, and change of astigmatism, coma abberation and CLMIaa (Cone Localisation and Magnitude Index). Aretrospective analytical study included 29 eyes of 24 patients who had progressed in the last 12 months and were suitable candidates for CXL surgery. The monitored parameters were the steepest, flatest and mean anterior instantaneous curvature (AICS, AICF, AICM) and the steepest, flatest and mean posterior instantaneous curvature (PICS, PICF, PICM) of the cornea, corneal thickness in the centre of the cornea (PACHC) and in the thinnest point of the cornea (PACHT), corneal astigmatism (ASTIG). coma (COMA), Cone Localization and Magnitude Index (CLMIaa) and uncorrected distance visual acuity (UDVA) with corrected distance visual acuity (CDVA). Data were analysed before surgery and 12 months after surgery. The AIC, COMA, CLMIaa and ASTIG parameters were analysed by paired t test. As the parameters of UDVA, CDVA, PIC and PACH did not meet the conditions of normal distribution, the Wilcoxon test was used to investigate the change in these parameters after CXL. Twelve months after the procedure, we recorded an improvement in UDVA (p=0.371) and CDVA (p=0.825), an increase in PICS, PICF and PICM (p=0.902; p=0.87 and p=0.555), adecrease in PACHCC (p=0.294) and adecrease in CLMIaa (p=0.113) that did not reach statistical significance. The decrease in PACHT (p=0.027), decrease in COMA (p=0.037) and decrease in anterior corneal curvature of AICS, AICF and AICM were statistically significant (p=0.019; p=0.010 and p=0.005). The decrease in the value of astigmatism did not show statistical significance, as p=0.297. CXL corneal therapy has been shown to be an effective method to stabilize the cornea in progressive keratoconus, and to improve the higher order of coma. This contributes to the possible improvement of UDVA and CDVA.

The study of the type material as well as the additional specimens collected in the Rumija Mts., southeastern Montenegro revealed that Bathyscia mikati Udržal, 1995 belongs to the genus Bathyscidius Jeannel, 1910. New combination, Bathyscidius mikati (Udržal, 1995) comb. nov. is established. The species redescription, morphological comparison with related species, revised distribution, the map and the catalogue for the genus are provided.

In an aim to contribute to already existing knowledge upon the subject of smart cities and the public sector’s wider knowledge in Europe, this study investigates the perception by the municipalities and the wider public sector, responsible for implementing smart solutions in the environment. The understanding of the concept of smart cities/villages by municipalities is on a low level due to the fact that the problem is too wide, not well described, solutions even wider, accompanied by the lack of experts able to offer comprehensive solutions to municipalities. The study presents factors according to the current municipalities’ knowledge (environmental awareness, knowledge and prior experience) and the existing market, of whether these factors can be said that affect the acceptance of smart cities. The public is already aware of the smart cities as a general concept, however, the study sheds light upon the established knowledge that the decision makers have in five countries, Hungary, Slovakia, Italy, Lithuania, and Denmark.

Anterior cruciate ligament (ACL) rupture is one of the most common traumatic injuries of the knee joint. Acute knee injury is often characterized by pain and the typical accompanying rupture sound. The injured person often feels pain in the knee, with swelling, the movement is painful in the full range of motion. The most commonly used test procedures for rupture include Lachman test, pivot shift test, anterior drawer and lever sign test. This review includes a description of individual tests and the diagnostic value of examination after the ACL rupture. The sensitivity and specificity of the lever sign test was 0.92-1.00, the specificity was 0.94-1.00. The anterior drawer testing reported sensitivity values ranged from 0.18 to 0.92 and specificity values ranged from 0.78 to 0.98. The sensitivity and specificity of the pivot shift test ranged from 0.18 to 0.48 and the specificity from 0.90 to 0.99. The sensitivity and specificity of the Lachman test were 0.63-0.93 and the specificity was 0.55-0.99. The lever sign test, the pivot shift test, the anterior drawer test and the Lachman test are valid parts of the anterior cruciate ligament examination with respect to the prediction of anterior cruciate ligament rupture using Magnetic Resonance Imaging and arthroscopy. Key words: rupture ligamentum cruciatum anterius, test maneuvers, lever sign test, pivot shift test, anterior drawer, Lachman test.