Opinion (Norway)

Abstract Clonal hematopoiesis (CH), a phenomenon linked to aging, correlates with inflammation and myeloid malignancies. Here, we explore the interaction of CH, with terminally differentiated lymphoid malignancy, and multiple myeloma (MM). Analysis of CH in clinical cohorts revealed a higher prevalence among MM patients and a lower deep response to proteasome inhibitors. By utilizing the bone marrow samples from MM patients with CH, single-cell transcriptome analyses indicated frequent interaction between CH and MM cells, mediated by CCR10-CCL2, resulting in the upregulation of the MAPK pathway and angiogenesis, findings corroborated by exosome RNA analysis. Conditioned media from TET2 knockdown macrophages significantly enhanced MM cell proliferation compared to that from wild-type cells, an effect reversible by a CCR10 inhibitor. Our results underscore the pivotal role of TET2 CH in driving CCR10-high myeloma progression through paracrine oncogenic effects via exosomal interactions on CCR10, suggesting its potential as a therapeutic target.

To compare postenhancement visual acuity between patients who underwent postcataract laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK). A private, tertiary referral practice in Sioux Falls, South Dakota. 3-year, retrospective chart review. Patients who underwent postcataract extraction excimer laser enhancement surgery targeted for emmetropia (±0.50 diopter). Postenhancement uncorrected distance visual acuity (UDVA) and manifest refraction spherical equivalent (MRSE) was recorded for all available follow-ups and compared for both groups. 822 postcataract enhanced eyes (491 LASIK; 331 PRK). For patients with at least 6-month follow-up, mean UDVA was 0.05 ± 0.13 logMAR in LASIK-enhanced patients and 0.15 ± 0.20 in PRK-enhanced patients ( P < .001). Mean absolute value MRSE was 0.22 ± 0.36 and 0.48 ± 0.62 for LASIK-enhanced and PRK-enhanced patients at or beyond 6 months, respectively ( P < .001). 330 (67%) LASIK-enhanced patients achieved 20/20 or better postenhancement UDVA, compared with 142 (43%) PRK-enhanced patients ( P < .001). Controlling for pre-enhancement UDVA, LASIK-enhanced patients showed significantly better postenhancement UDVA than PRK-enhanced patients, except in those with pre-enhancement vision of 20/20 or better, or those worse than 20/50. LASIK-enhanced virgin corneas had mean postenhancement of 0.05 ± 0.14 UDVA compared with 0.13 ± 0.19 UDVA in PRK-enhanced virgin cornea patients ( P < .001). LASIK provides better and more predictable outcomes in UDVA than PRK in postcataract enhancement patients, even when controlling for pre-enhancement visual acuity and prior ocular procedures.

Not available.

Las Asociaciones Público-Privadas (Asociaciones Público Privadas (APPs) son un mecanismo por el cual se realizó en Colombia la creación de un marco legal que permite y promueve la inversión y participación de los particulares, para la construcción, gestión y administración de bienes de uso público como lo son los grandes corredores viales, y toda infraestructura relacionada con la prestación de servicios públicos. Por tanto, es importante considerar la naturaleza, y evolución jurídica de los riesgos. Con este objeto se acudirá a elementos normativos, tales como: los antecedentes legales, jurisprudenciales y de análisis doctrinal, necesarios para tipificar, estimar y asignar los riesgos en los proyectos que se llevan a cabo bajo el esquema Asociaciones Público Privadas (APPs).

Public opinion research has been under a great deal of criticism over the last few years as it failed to accurately predict a series of important outcomes around the world. As a result, polls are now assumed to be inaccurate at best, manipulative at worst. Nevertheless, corporations, the media, interest groups and politicians alike continue to rely heavily on them for guidance and strategic insights. The aim of this book is to examine the status of market intelligence in practice and how changes in its different contributing streams-media polling, commercial public opinion research and political polling-are pushing market intelligence into a new phase of development. This book suggests that we are moving to a new phase where the practice of market intelligence will be more akin to market surveillance and this field is on the verge of a major transformation. André Turcotte is an Associate Professor at the School of Journalism and Communication, Carleton University, Canada. He has worked with several polling firms over the years and has provided opinion research advice to several politicians, corporations and organizations

: Recent efforts in precision medicine present unique opportunities for military environmental and occupational health. Risk assessments can be refined by individualized risk factors such as genomics, and health status can be monitored and informed using mobile health (mHealth) devices. The military currently monitors exposures with service-wide databases and has one of the world's largest biobanks of serum samples available for health surveillance. New approaches are being developed for risk assessment, novel exposure-based biomarkers, and mobile applications to combine the facile collection of exposure data with tracking and planning utility. Planning by military leaders and coordination with national efforts puts the Department of Defense (DoD) in a unique position to benefit both Service Members and the nation, as reviewed in a symposium cosponsored by the DoD and the Johns Hopkins University-Applied Physics Laboratory (October 27 to 28, 2015).

Las clases de geografía física se pueden ser organizadas a partir de las oportunidades de empleo ofrecidas por la cartografía. El conocimiento científico, en este artículo, sigue como un procedimiento para el desarrollo del pensamiento matemático (espacial) y geográfico, hace posible que los estudiantes participen de las investigaciones y problematizasen sus observaciones sobre el proceso en cuestión. La rectificación de las primeras opiniones, para la elaboración de hipótesis y la construcción de las preguntas fueron ejercidas por los estudiantes, dando a los investigadores una perspectiva doble: el conocimiento previo y el conocimiento científico para el logro de aprendizajes. Se nota en este estudio, la capacidad de las clases investigando desde el punto de vista del profesor hasta el de los estudiantes.

Many studies have looked at benefits of breastfeeding for the baby and, less frequently, the mother. Though many women find breastfeeding difficult, few studies have looked at the potential costs of breastfeeding for this group. From January 19th 2015 through April 18th 2015, the total of 1,980 Serbian mothers completed an on-line survey consisting of 74 questions which addressed their satisfaction with various areas of life. Mothers were divided into four groups depending on their breastfeeding experience: those who enjoy breastfeeding (Group 1), those who breastfeed despite finding it difficult (Group 2), those who do not breastfeed because they find it difficult, but otherwise would (Group 3) and those who do not breastfeed because ?it is their choice? (Group 4). There were 1,238 women (53.2%) in Group, 1, 546 (23.4%) in Group 2, 147 (6.3%) in Group 3 and 49 (2.1%) in Group 4. Group 2 scored lower than Group 1 on 25 out of 26 indicators of satisfaction. When these 26 indicators were averaged, there was a significant difference in the average scores between Group 1 (M = 6.87, SD = 1.10) and Group 2 (M = 6.33, SD = 1.20). Group 3 scored higher than Group 2 on 19 out of 26 indicators. There is a remarkably consistent difference in satisfaction across many areas of life between women who breastfeed joyfully and those who do it out of a sense of duty. As public pressure on women to breastfeed mounts, distinction between these two kinds of breastfeeding experiences should be kept in mind.