OvaScience (United States)

Objectives: Androgen-deprivation therapy (ADT) for prostate cancer (PCa) is associated with reduced physical function and quality of life (QoL). We investigated the impact of a structured lifestyle intervention on the promotion of physical activity (PA) and reduction of sedentary behavior (SB), and its effect on QoL in men on ADT. Methods: Patients with advanced PCa on long-term ADT were randomized to the intervention (N = 11) or a control arm (N = 10) between February 2018 and May 2019. The intervention group received a structured lifestyle intervention including motivational text messages for 8 weeks (maintenance visit at week 12). At each visit, self-report measures and accelerometer data were used to assess PA and SB, and questionnaires were used to measure QoL, life satisfaction, anxiety, and depression. Results: Significantly greater improvements in QoL and depression compared to baseline were reported in the intervention group compared to the control group. In addition, the intervention group also showed a significantly greater increase in self-reported light, as well as moderate-to-vigorous PA, and reduction in self-reported SB. Conclusions: Given its inherent advantage in improving QoL and reducing depression, a lifestyle intervention program should be offered to patients on ADT.

In November 2017, COAR published the report, Behaviours and Technical Recommendations of the COAR Next Generation Repositories Working Group. The report published a list of 19 technologies and protocols that are recommended to improve the way repositories function. There is tremendous interest in the community related to the vision of next generation repositories. COAR is helping to advance this vision and also monitoring developments so that we avoid redundancy of efforts. Significant progress has already been made in terms of adoption of some of the technologies into the open source platforms. This panel will have representatives from the open source repository community and platform developers to provide updates about the progress towards adoption of the NGR technologies, discuss any associated challenges, and look into the future to identify any new technologies on the horizon.